Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Athenex
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Oral paclitaxel, relative to intravenous paclitaxel, was associated with less neuropathy and was not associated with an increase in febrile neutropenia.
Product Name : Taxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
December 20, 2022
Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Athenex
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The publication of phase 3 data, which show that oral Taxol (paclitaxel) plus encequidar significantly improves tumor response in patients with metastatic breast cancer, compared to IV administration.
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
July 25, 2022
Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The agreement will support the expansion phase of the trial to further investigate the preliminary encouraging results of the KX-ORAX-011 Phase 1 clinical trial evaluating Oraxol (encequidar plus oral paclitaxel) in combination with pembrolizumab for cer...
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Undisclosed
May 16, 2022
Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Post hoc analysis of this subgroup of patients with hepatic impairment was conducted and showed a median survival rate of 18.9 months in patients treated with Oral Paclitaxel.
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
November 22, 2021
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Athenex Presents Data from Oral Paclitaxel + Pembrolizumab Phase 1 Study at ESMO 2021
Details : The primary objective for dose escalation phase of the study was to determine the maximum tolerated dose (MTD) and identify the recommended Phase 2 dose (RP2D) of Oraxol (Oral Paclitaxel + Encequidar) in combination with pembrolizumab in patients with ad...
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
September 16, 2021
Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : In the CRL, the FDA indicated its concern of safety risk to patients in terms of an increase in neutropenia-related sequelae on the Oral Paclitaxel arm compared with the IV paclitaxel arm.
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
March 01, 2021
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data presented at SABCS indicates benefits of oral paclitaxel and encequidar (oral paclitaxel) versus IV paclitaxel (IVP) on Progression-Free Survival (PFS) and on Overall Survival (OS), which supports superiority on the primary endpoint Overall Response...
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
December 09, 2020
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Presentations will include data from the pivotal Phase 3 clinical trial of oral paclitaxel in metastatic breast cancer, a spotlight poster on progression-free survival and overall survival, and posters on neuropathy (CIPN), and management of gastrointest...
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
November 17, 2020
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The Oral Paclitaxel NDA submission is supported by data from a single pivotal Phase III study of Oral Paclitaxel for the treatment of metastatic breast cancer.
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
September 01, 2020
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Athenex presented interim data from an ongoing Phase II clinical trial in which oral paclitaxel and encequidar monotherapy showed encouraging efficacy and tolerability in elderly patients with unresectable cutaneous angiosarcoma, an aggressive malignancy...
Product Name : Oraxol
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
May 29, 2020
Lead Product(s) : Paclitaxel,Encequidar
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable