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Athenex","highestDevelopmentStatusID":"8","companyTruncated":"Quantum Leap Healthcare \/ Athenex"},{"orgOrder":0,"company":"Athenex","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2022","type":"Collaboration","leadProduct":"Paclitaxel","moa":"||Microtubule depolymerization","graph1":"Oncology","graph2":"Phase I","graph3":"Athenex","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Athenex \/ Merck & Co","highestDevelopmentStatusID":"6","companyTruncated":"Athenex \/ Merck & Co"},{"orgOrder":0,"company":"Athenex","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2021","type":"Inapplicable","leadProduct":"Paclitaxel","moa":"||Microtubule depolymerization","graph1":"Oncology","graph2":"Phase I","graph3":"Athenex","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Athenex \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Athenex \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals for Encequidar

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                          01

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Oral paclitaxel, relative to intravenous paclitaxel, was associated with less neuropathy and was not associated with an increase in febrile neutropenia.

                          Product Name : Taxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          December 20, 2022

                          Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Athenex

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : The publication of phase 3 data, which show that oral Taxol (paclitaxel) plus encequidar significantly improves tumor response in patients with metastatic breast cancer, compared to IV administration.

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          July 25, 2022

                          Lead Product(s) : Paclitaxel,Dostarlimab,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : The agreement will support the expansion phase of the trial to further investigate the preliminary encouraging results of the KX-ORAX-011 Phase 1 clinical trial evaluating Oraxol (encequidar plus oral paclitaxel) in combination with pembrolizumab for cer...

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Undisclosed

                          May 16, 2022

                          Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Merck & Co

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          04

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Post hoc analysis of this subgroup of patients with hepatic impairment was conducted and showed a median survival rate of 18.9 months in patients treated with Oral Paclitaxel.

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          November 22, 2021

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : The primary objective for dose escalation phase of the study was to determine the maximum tolerated dose (MTD) and identify the recommended Phase 2 dose (RP2D) of Oraxol (Oral Paclitaxel + Encequidar) in combination with pembrolizumab in patients with ad...

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 16, 2021

                          Lead Product(s) : Paclitaxel,Encequidar,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          06

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : In the CRL, the FDA indicated its concern of safety risk to patients in terms of an increase in neutropenia-related sequelae on the Oral Paclitaxel arm compared with the IV paclitaxel arm.

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          March 01, 2021

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Data presented at SABCS indicates benefits of oral paclitaxel and encequidar (oral paclitaxel) versus IV paclitaxel (IVP) on Progression-Free Survival (PFS) and on Overall Survival (OS), which supports superiority on the primary endpoint Overall Response...

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          December 09, 2020

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Presentations will include data from the pivotal Phase 3 clinical trial of oral paclitaxel in metastatic breast cancer, a spotlight poster on progression-free survival and overall survival, and posters on neuropathy (CIPN), and management of gastrointest...

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          November 17, 2020

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : The Oral Paclitaxel NDA submission is supported by data from a single pivotal Phase III study of Oral Paclitaxel for the treatment of metastatic breast cancer.

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 01, 2020

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Athenex presented interim data from an ongoing Phase II clinical trial in which oral paclitaxel and encequidar monotherapy showed encouraging efficacy and tolerability in elderly patients with unresectable cutaneous angiosarcoma, an aggressive malignancy...

                          Product Name : Oraxol

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 29, 2020

                          Lead Product(s) : Paclitaxel,Encequidar

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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