Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ENV-101 Phase 2a Shows Lung Function, Fibrosis Reversal in IPF
Details : ENV-101 (taladegib) is an oral small molecule inhibitor of the Hedgehog (Hh) signaling pathway. It is being evaluated in phase 2 clinical studies for the treatment of idiopathic pulmonary fibrosis.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 19, 2024
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : AyurMaya
Deal Size : $132.5 million
Deal Type : Series C Financing
Endeavor Raises $132.5 Million in Oversubscribed Series C for Medicines Pipeline
Details : Endeavor will use the financing proceeds to advance the clinical development of ENV-101, its lead candidate for the treatment of idiopathic pulmonary fibrosis.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Undisclosed
April 24, 2024
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : AyurMaya
Deal Size : $132.5 million
Deal Type : Series C Financing
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Endeavor Completes Phase 2a Of ENV-101 In Patients With Idiopathic Pulmonary Fibrosis
Details : ENV-101 (taladegib) is an oral small molecule inhibitor of the Hedgehog (Hh) signaling pathway. It is being evaluated in phase 2 clinical studies for the treatment of idiopathic pulmonary fibrosis.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 24, 2024
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : HMBD-501
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Hummingbird Bioscience
Deal Size : $430.0 million
Deal Type : Licensing Agreement
Details : Under the agreement, Endeavor has acquired exclusive worldwide rights to Hummingbird Bio’s HMBD-501, a next-generation HER3-targeted antibody-drug conjugate (ADC).
Brand Name : HMBD-501
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 19, 2023
Lead Product(s) : HMBD-501
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Hummingbird Bioscience
Deal Size : $430.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ENV-101 (taladegib) is a small-molecule inhibitor of the Hedgehog (Hh) signaling pathway, which plays a critical role in idiopathic pulmonary fibrosis disease pathology.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 06, 2023
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The partnership helps identify patients whose cancers harbor the PTCH1 mutation and may be eligible for Endeavor’s clinical trial for ENV-101 (taladegib). The xCures platform also enables patients to find more suitable treatment options if they are ine...
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 31, 2022
Details : ENV-101 (taladegib), an orally available small molecule inhibitor of the Hedgehog signaling pathway, has already demonstrated preliminary clinical efficacy and safety in nearly 200 subjects enrolled across six completed studies.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 25, 2022
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Ally Bridge Group
Deal Size : $101.0 million
Deal Type : Series B Financing
Details : Proceeds will support the Endeavor’s pipeline, including ENV-101 (taladegib), a small molecule inhibitor of PTCH1 receptor, for the treatment of cancer and idiopathic pulmonary fibrosis and ENV-201, a small molecule inhibitor of ULK1/2 for the treatmen...
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 07, 2022
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Ally Bridge Group
Deal Size : $101.0 million
Deal Type : Series B Financing
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase I
Sponsor : Omega Funds
Deal Size : $62.0 million
Deal Type : Series A Financing
Details : Proceeds from the financing will be used to advance taladegib, an inhibitor of the Hedgehog pathway, into two Phase 2 clinical studies for the treatment of idiopathic pulmonary fibrosis (IPF) in 2021.
Brand Name : ENV-101
Molecule Type : Small molecule
Upfront Cash : Undisclosed
January 07, 2021
Lead Product(s) : Taladegib
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase I
Sponsor : Omega Funds
Deal Size : $62.0 million
Deal Type : Series A Financing
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