Lead Product(s) : PRV-101
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Publication results demonstrates that a preclinical prototype of Provention's polyvalent coxsackievirus B (CVB) vaccine, PRV-101, is well-tolerated, immunogenic and highly protective in relevant animal models.
Brand Name : Undisclosed
Molecule Type : Vaccine
Upfront Cash : Not Applicable
May 18, 2020
Lead Product(s) : PRV-101
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Provides Clearance to IND Application for Type 1 Diabetes Therapy SAB-142 by SAB Bio
Details : SAB-142 is a human alternative to rabbit anti-thymocyte globulin, SAB-142’s mechanism of action is analogous to that of rabbit ATG, which is being clinically validated in the clinical trials for T1D.
Brand Name : SAB-142
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 21, 2024
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SAB-142 is the first fully-human anti-thymocyte hpAB therapeutic currently being developed for delaying the progression and onset of type 1 diabetes, among other autoimmune indications.
Brand Name : SAB-142
Molecule Type : Large molecule
Upfront Cash : Not Applicable
October 19, 2023
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : BMF-219
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BMF-219 is a novel covalent menin inhibitor designed to regenerate insulin-producing beta cells with the aim to cure type 1 diabetes. The FDA has cleared the initiation of COVALENT-112, a Phase II clinical trial.
Brand Name : BMF-219
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 05, 2023
Lead Product(s) : BMF-219
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : RA Capital Management
Deal Size : $130.0 million
Deal Type : Private Placement
Details : SAB will use the funds to clinically advance SAB-142, a fully-human alternative to rabbit anti-thymocyte globulin (rATG), its lead therapeutic candidate for type 1 diabetes (T1D).
Brand Name : SAB-142
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 02, 2023
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : RA Capital Management
Deal Size : $130.0 million
Deal Type : Private Placement
Lead Product(s) : MBX 1416
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : MBX 1416 is an investigational long-acting GLP-1 receptor antagonist in development as a potential treatment for Post-Bariatric Hypoglycemia. It was designed using the company’s novel, proprietary PEP platform to prevent the occurrence of severe hypogl...
Brand Name : MBX 1416
Molecule Type : Peptide
Upfront Cash : Not Applicable
August 07, 2023
Lead Product(s) : MBX 1416
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VX-264
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VX-264 is an investigational cell therapy in which allogeneic human stem cell-derived islets are encapsulated in a channel array device designed to shield the cells from the body’s immune system. It is currently being evaluated for patients with T1D.
Brand Name : VX-264
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 09, 2023
Lead Product(s) : VX-264
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : SAB-142 is the first fully-human anti-thymocyte hpAB therapeutic currently being developed for delaying the progression and onset of type 1 diabetes, among other autoimmune indications.
Brand Name : SAB-142
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 10, 2023
Lead Product(s) : SAB-142
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALN-KHK
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALN-KHK is an investigational, subcutaneously administered RNAi therapeutic targeting ketohexokinase for the treatment of Type 2 diabetes mellitus (T2DM). The safety and efficacy of ALN-KHK have not been evaluated by the FDA, EMA, Health Canada, or any o...
Brand Name : ALN-KHK
Molecule Type : Large molecule
Upfront Cash : Not Applicable
December 21, 2022
Lead Product(s) : ALN-KHK
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : BMF-219
Therapeutic Area : Endocrinology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : In animal models, BMF-219 has shown a very unique profile in preserving, reactivating and regenerating beta cells. BMF-219 was designed to specifically inhibit menin.
Brand Name : BMF-219
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 14, 2022
Lead Product(s) : BMF-219
Therapeutic Area : Endocrinology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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