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    [{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"National Center for Advancing Translational Sciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Collaboration","leadProduct":"Enkephalin","moa":"Delta opioid receptor","graph1":"Neurology","graph2":"Preclinical","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intranasal Spray","sponsorNew":"Virpax Pharmaceuticals \/ National Center for Advancing Translational Sciences","highestDevelopmentStatusID":"4","companyTruncated":"Virpax Pharmaceuticals \/ National Center for Advancing Translational Sciences"},{"orgOrder":0,"company":"Societal CDMO","sponsor":"National Institutes of Health","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Funding","leadProduct":"Enkephalin","moa":"MAO transporter","graph1":"Neurology","graph2":"Preclinical","graph3":"Societal CDMO","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Nasal Spray","sponsorNew":"Societal CDMO \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"Societal CDMO \/ National Institutes of Health"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"National Institutes of Health","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Peptide","year":"2021","type":"Agreement","leadProduct":"Enkephalin","moa":"Delta opioid receptor","graph1":"Neurology","graph2":"IND Enabling","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intranasal Spray","sponsorNew":"Virpax Pharmaceuticals \/ National Institutes of Health","highestDevelopmentStatusID":"5","companyTruncated":"Virpax Pharmaceuticals \/ National Institutes of Health"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Peptide","year":"2022","type":"Not Applicable","leadProduct":"Enkephalin","moa":"Delta opioid receptor","graph1":"Neurology","graph2":"Preclinical","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intranasal Spray","sponsorNew":"Virpax Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Virpax Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Enkephalin","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Spray","sponsorNew":"Virpax Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"Virpax Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Enkephalin","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Spray","sponsorNew":"Virpax Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"Virpax Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Virpax Pharmaceuticals","sponsor":"NCATS","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Peptide","year":"2024","type":"Agreement","leadProduct":"Enkephalin","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Virpax Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Virpax Pharmaceuticals \/ NCATS","highestDevelopmentStatusID":"12","companyTruncated":"Virpax Pharmaceuticals \/ NCATS"}]

    Find Clinical Drug Pipeline Developments & Deals for Enkephalin

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    Enkephalin

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                            01

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : NCATS

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Virpax Develops NES100 for Acute and Chronic Pain with HHS Agreement

                            Details : The collaboration aims for the continued development of Virpax’s product candidate, NES100 (leucine enkephalin), an intranasal peptide, for the management of acute and chronic non-cancer pain.

                            Brand Name : NES100

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            November 21, 2024

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : NCATS

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Virpax Pharmaceuticals Announces that Envelta™ Remains on Track for Trial in Humans Following FDA Review

                            Details : Envelta (MET-LENK) is a non-addictive intranasal molecular envelope endogenous enkephalin formulation being developed to manage acute and chronic pain, including pain associated with cancer.

                            Brand Name : Envelta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 31, 2023

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Virpax Announces Positive Preclinical Toxicology Results in Support of Molecular Envelope Technology (MET)

                            Details : Envelta™ is an intranasal molecular envelope endogenous enkephalin formulation being developed to manage acute and chronic pain, including pain associated with cancer.

                            Brand Name : Envelta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 13, 2023

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Virpax Reports Favorable Preclinical Safety Data for Envelta™ for the Treatment of Acute and Chronic Pain

                            Details : Envelta is an investigational intranasal formulation intended to improve enkephalin transport to the brain. Envelta uses a preassembled device and cartridge to propel the enkephalin formulation through the nose to the brain by flowing along the olfactory...

                            Brand Name : Envelta

                            Molecule Type : Peptide

                            Upfront Cash : Not Applicable

                            February 10, 2022

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Virpax Advances Envelta™ Development with NCATS Under CRADA Agreement

                            Details : The NIH has contracted with a clinical research organization to conduct additional pre-clinical efficacy studies for Envelta and procured a device to be used with the manufactured GMP drug product for preclinical and clinical studies.

                            Brand Name : Envelta

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            November 10, 2021

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            Societal CDMO

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                            Societal CDMO

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Recro Awarded Development and Manufacturing Contract by National Institutes of Health (NIH) to Support Novel N...

                            Details : Under terms of the new contract, the company will support CMC's of NES-100, a microparticle dosage form of leu-enkephalin (LENK) that is prepared by the encapsulation of LENK in a patent-protected molecular enveloped technology and delivered via a nasal ...

                            Brand Name : NES-100

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            October 20, 2021

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : Undisclosed

                            Deal Type : Funding

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                            07

                            Virpax Pharmaceuticals

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                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : National Center for Advancing Translational Sciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Virpax to Use Envelta™ IND Enabling Study Results for Two Additional Indications

                            Details : Envelta™ is an investigational intranasal formulation intended to improve enkephalin transport to the brain. Enkephalin is a naturally occurring (endogenous) peptide that is not easily administered in its original form.

                            Brand Name : Envelta

                            Molecule Type : Peptide

                            Upfront Cash : Undisclosed

                            June 21, 2021

                            Lead Product(s) : Enkephalin

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : National Center for Advancing Translational Sciences

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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