Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensysce Reports Positive Progress in PF614-MPAR Pain Treatment Trial
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Controlled Substance
Upfront Cash : Inapplicable
February 05, 2025
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : PF614,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensysce Biosciences Announces Positive Interim Data for Breakthrough Therapy PF614-MPAR
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Controlled Substance
Upfront Cash : Inapplicable
January 22, 2025
Lead Product(s) : PF614,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Ensysce Develops PF614 & PF614-MPAR Through Strategic Partnership
Details : The initiation of a strategic partnership with a leading specialty drug manufacturer for the development and commercial launch of PF614 for pain.
Product Name : PF614
Product Type : Small molecule
Upfront Cash : Undisclosed
December 04, 2024
Ensysce Biosciences Doses First Subjects in PF614-MPAR Trial
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Small molecule
Upfront Cash : Not Applicable
November 26, 2024
Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride
Therapeutic Area : Neurology
Study Phase : Phase I
Recipient : Quotient Sciences
Deal Size : Undisclosed
Deal Type : Collaboration
Ensysce Advances Overdose Protection Platform in Clinical Development
Details : The collaboration aims to examine and evaluate the full commercial dose range of the PF614-MPAR drug product, the combination of PF614 with the trypsin inhibitor nafamostat, to treat chronic pain.
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Undisclosed
May 20, 2024
Lead Product(s) : Oxycodone Prodrug,Nafamostat Hydrochloride
Therapeutic Area : Neurology
Highest Development Status : Phase I
Recipient : Quotient Sciences
Deal Size : Undisclosed
Deal Type : Collaboration
Ensysce Biosciences Reports Positive End of Phase 2 Meeting with FDA for PF614 Severe Pain
Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.
Product Name : PF614
Product Type : Small molecule
Upfront Cash : Not Applicable
January 31, 2024
Lead Product(s) : Oxycodone Prodrug
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : $1.7 million
Deal Type : Private Placement
Ensysce Biosciences Secures $1.7 Million Convertible Note Financing
Details : The financing will support the completion of a time of onset study and regulatory milestones for company's lead product, PF614, a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone, being studied as chronic pain analgesic.
Product Name : PF614
Product Type : Small molecule
Upfront Cash : Undisclosed
October 24, 2023
Lead Product(s) : Oxycodone Prodrug
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : $1.7 million
Deal Type : Private Placement
Lead Product(s) : Oxycodone Prodrug
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Ensysce Biosciences Announces IRB Approval of Key Study Protocol
Details : PF614 is a chemically modified opioid product that requires initial metabolic transformation by trypsin in the small intestine for activation to be able to relieve severe pain in patients who require an opioid-level analgesic.
Product Name : PF614
Product Type : Small molecule
Upfront Cash : Not Applicable
August 09, 2023
Lead Product(s) : Oxycodone Prodrug
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Not Applicable
February 14, 2023
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Study Phase : Phase I
Recipient : Quotient Sciences
Deal Size : Not Applicable
Deal Type : Not Applicable
Ensysce Biosciences' PF614-MPAR Enters Final Stage of Phase 1 Study
Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...
Product Name : PF614-MPAR
Product Type : Small molecule
Upfront Cash : Not Applicable
January 25, 2023
Lead Product(s) : Oxycodone Prodrug,Nafamostat
Therapeutic Area : Neurology
Highest Development Status : Phase I
Recipient : Quotient Sciences
Deal Size : Not Applicable
Deal Type : Not Applicable