Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Leuprolide Acetate
Therapeutic Area : Obstetrics/Gynecology (Women’s Health)
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Ovarest® (leuprolide) is a gonadotropin-releasing hormone analogue that is used to treat endometriosis and uterine fibroids in women, prostate cancer in men, and central precocious puberty in boys and girls.
Brand Name : Ovarest
Molecule Type : Peptide
Upfront Cash : Not Applicable
October 26, 2022
Lead Product(s) : Leuprolide Acetate
Therapeutic Area : Obstetrics/Gynecology (Women’s Health)
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : CARA Therapeutics
Deal Size : $46.0 million
Deal Type : Licensing Agreement
Details : The milestone payment is related to continued clinical progress of Oral KORSUVA (difelikefalin), which is currently the subject of four separate clinical programs for pruritus in patients with hepatic impairment due to primary biliary cholangitis.
Brand Name : Korsuva
Molecule Type : Peptide
Upfront Cash : $8.0 million
October 10, 2022
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : CARA Therapeutics
Deal Size : $46.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Leuprolide Acetate
Therapeutic Area : Obstetrics/Gynecology (Women’s Health)
Study Phase : Phase II
Sponsor : SWK Holdings
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Oral administration of Ovarest (leuprolide) offers the potential to better address diseases in which gonadotropin-releasing hormone (GnRH) agonists are known to provide benefit and for which an oral format can improve patient compliance.
Brand Name : Ovarest
Molecule Type : Peptide
Upfront Cash : Not Applicable
July 14, 2022
Lead Product(s) : Leuprolide Acetate
Therapeutic Area : Obstetrics/Gynecology (Women’s Health)
Highest Development Status : Phase II
Sponsor : SWK Holdings
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : CARA Therapeutics
Deal Size : $25.0 million
Deal Type : Licensing Agreement
Details : Enteris is eligible to receive additional potential milestone payments over the next several quarters, subject to the achievement of certain development milestones for Oral KORSUVA, of which Enteris will retain half.
Brand Name : Korsuva
Molecule Type : Peptide
Upfront Cash : $5.0 million
December 09, 2021
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : CARA Therapeutics
Deal Size : $25.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Difelikefalin
Therapeutic Area : Nephrology
Study Phase : Phase II
Sponsor : CARA Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Details : This milestone payment was triggered by confirmation from Cara of the completion of an End-of-Phase 2 Meeting with the U.S. Food and Drug Administration (FDA) for Oral KORSUVA in patients with non-dialysis dependent (NDD) chronic kidney disease (CKD-aP).
Brand Name : Korsuva
Molecule Type : Peptide
Upfront Cash : $8.0 million
June 11, 2021
Lead Product(s) : Difelikefalin
Therapeutic Area : Nephrology
Highest Development Status : Phase II
Sponsor : CARA Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : CARA Therapeutics
Deal Size : $13.0 million
Deal Type : Licensing Agreement
Details : Enteris BioPharma, received a second milestone payment from Cara Therapeutics (Nasdaq: CARA) related to the license agreement for Peptelligence oral formulation technology utilized in Oral KORSUVA, the oral formulation of Cara’s first-in-class KOR agon...
Brand Name : Korsuva
Molecule Type : Peptide
Upfront Cash : $8.0 million
December 24, 2020
Lead Product(s) : Difelikefalin
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : CARA Therapeutics
Deal Size : $13.0 million
Deal Type : Licensing Agreement
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