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            Amgen & Eisai to participate in the immune modulation domain of REMAP-COVID, an adaptive clinical trial to test interventions for patients hospitalized with COVID-19. Amgen’s Apremilast & Eisai’s Eritoran to be evaluated across multiple international trial sites.

            Lead Product(s): Apremilast,Eritoran,Hydrocortisone

            Therapeutic Area: Infections and Infectious Diseases Product Name: Otezla

            Highest Development Status: Phase IV Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 27, 2020

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            National Center for Global Health and Medicine

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            In this collaborative research, a non-clinical animal model of SARS-CoV-2 infection will be constructed. Additionally, TLR4 antagonist eritoran, discovered by Eisai, and an anti-FKN antibody E6011, KAN Research Institute, will be evaluated.

            Lead Product(s): Eritoran

            Therapeutic Area: Infections and Infectious Diseases Product Name: E5564

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Eisai

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration October 06, 2020

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            The trial will be conducted in the multi-hospital UPMC health system along with other medical centers in the United States. Additional global sites across the trial network, including Japan, will follow.

            Lead Product(s): Eritoran

            Therapeutic Area: Infections and Infectious Diseases Product Name: E5564

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: The Global Coalition for Adaptive Research

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership July 01, 2020

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            Eisai has resuscitated its once-jettisoned sepsis drug eritoran, otherwise known as E5564, for the treatment of COVID-19, planning to launch a global clinical trial as early as June.

            Lead Product(s): Eritoran

            Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

            Highest Development Status: Undisclosed Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 29, 2020

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