Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : YH008
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Chipscreen NewWay Biosciences
Deal Size : $85.9 million
Deal Type : Licensing Agreement
Details : Eucure Biopharma retains YH008’s global rights to develop and commercialize YH008 outside Greater China. YH008 is Biocytogen’s independently developed proprietary bispecific antibody for tumor immunotherapy that exerts antagonistic and agonistic acti...
Brand Name : YH008
Molecule Type : Large molecule
Upfront Cash : $5.7 million
February 27, 2023
Lead Product(s) : YH008
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Chipscreen NewWay Biosciences
Deal Size : $85.9 million
Deal Type : Licensing Agreement
Details : YH003 is a humanized IgG2 agonistic CD40 antibody. Whether used as a single agent or in combination with anti-PD-1 monoclonal antibody drugs, YH003 demonstrated strong anti-tumor effects against multiple tumor.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Undisclosed
November 01, 2022
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : ISU ABXIS
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Under the terms of the agreement, ISU ABXIS will utilize the sequence of YH003, Biocytogen’s humanized agonistic anti-CD40 antibody currently in phase II clinical trials, to construct a few groups of tri-specific antibodies and develop cancer drugs for...
Brand Name : YH003
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 31, 2022
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : ISU ABXIS
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Under the terms of the agreement, Syncromune will acquire exclusive worldwide rights for development and commercialization of the intratumoral combination therapy containing Eucure’s YH002, and multiple other active ingredients as part of the Syncrovax...
Brand Name : YH002
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 17, 2022
Lead Product(s) : YH002,YH001
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Biocytogen
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Combination of YH002, a recombinant anti-OX40 humanized IgG1 antibody and YH001, an anti-CTLA-4 monoclonal antibody has shown very good antitumor activity, in invivo efficacy screening platform in patients with advanced solid tumors.
Brand Name : YH002
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 08, 2022
Lead Product(s) : YH002,YH001
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Biocytogen
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Biocytogen/Eucure Biopharma's CTLA-4 and CD40 mAbs Approved for Phase II Clinical Trials by the FDA
Details : A phase II, open-label, multi-center study will evaluate the safety and efficacy of YH003 combined with Toripalimab for the treatment of PD-1-resistant unresectable/metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC).
Brand Name : YH003
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 06, 2021
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The first trial is designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor efficacy of YH003 combined with Toripalimab (Tuoyi®; an anti-PD-1 mAb) in subjects with advanced solid tumors.
Brand Name : YH003
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 02, 2021
Lead Product(s) : YH003,Toripalimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Humanized IgG2 Agonistic Monoclonal Antibody,Toripalimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Preclinical studies demonstrated that YH003 promotes antigen-presenting cell activation and infiltration of effector T cells into tumors.
Brand Name : YH003
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 01, 2021
Lead Product(s) : Humanized IgG2 Agonistic Monoclonal Antibody,Toripalimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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