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    [{"orgOrder":0,"company":"Eureka Therapeutics","sponsor":"Lyell Immunopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Series E Financing","leadProduct":"ET140202","moa":"Alpha-fetoprotein","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Eureka Therapeutics","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.050000000000000003,"dosageForm":"","sponsorNew":"Eureka Therapeutics \/ Lyell Immunopharma","highestDevelopmentStatusID":"7","companyTruncated":"Eureka Therapeutics \/ Lyell Immunopharma"},{"orgOrder":0,"company":"Eureka Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2020","type":"Not Applicable","leadProduct":"ET140203","moa":"Alpha fetoprotein","graph1":"Oncology","graph2":"Phase I\/ Phase 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Therapeutics","sponsor":"CIRM","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Funding","leadProduct":"Autologous T Cell-based Therapy","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Eureka Therapeutics","amount2":0.01,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.01,"dosageForm":"Infusion","sponsorNew":"Eureka Therapeutics \/ CIRM","highestDevelopmentStatusID":"7","companyTruncated":"Eureka Therapeutics \/ CIRM"},{"orgOrder":0,"company":"Eureka Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"ECT204","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Eureka Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            Eureka Therapeutics

                            U.S.A arrow
                            euroPLX 86 Munich
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                            Eureka Therapeutics

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                            Lead Product(s) : ECT204

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Advances ARYA-3 Phase II Trial of GPC3-Targeting T-cell Therapy for Liver Cancer

                            Details : ECT204 is an autologous T-cell therapy where T cells are transduced with a lentiviral vector expressing the ECT204 transgene, evaluated for GPC3-positive advanced hepatocellular carcinoma treatment.

                            Brand Name : ECT204

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 18, 2024

                            Lead Product(s) : ECT204

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : Autologous T Cell-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : CIRM

                            Deal Size : $10.6 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Awarded $10.6 Million CIRM Grant to Support Clinical Trial of ARTEMIS® T-Cell Therapy in ...

                            Details : The grant will support company's ongoing ARYA-2 Phase I study of ET140203, an autologous T cell-based therapy, for the treatment of pediatric patients with refractory/relapsed liver cancer, including hepatoblastoma, hepatocellular neoplasm not otherwise ...

                            Brand Name : ET140203

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 06, 2023

                            Lead Product(s) : Autologous T Cell-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : CIRM

                            Deal Size : $10.6 million

                            Deal Type : Funding

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                            03

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Eureka Therapeutics

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                            Lead Product(s) : T-cell based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Licenses Promising Antibody Targeting Mesothelin from the National Cancer Institute

                            Details : Under the licensing agreement, Eureka will develop and commercialize a novel antibody targeting MSLN, a potentially transformative T-cell therapy for solid tumors, in combination with ARTEMIS® T-cell receptor platform.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 14, 2023

                            Lead Product(s) : T-cell based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            04

                            Eureka Therapeutics

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                            euroPLX 86 Munich
                            Not Confirmed

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : ARTEMIS T-cell Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Announces License with the National Cancer Institute to Advance GPC2 ARTEMIS® T Cell Ther...

                            Details : The therapy also has expansion potential in medulloblastoma and small cell lung cancer, among several other pediatric and adult cancers that express an abundance of the GPC2 protein on their cell surface.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            October 18, 2022

                            Lead Product(s) : ARTEMIS T-cell Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            05

                            Eureka Therapeutics

                            U.S.A arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Eureka Therapeutics

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Receives Orphan Drug Designations for Treatment of Hepatoblastoma with ET140203 ARTEMIS® ...

                            Details : ET140203 is an investigational therapy during which a patient’s T cells are collected, engineered to express Eureka’s proprietary ARTEMIS® cell receptor and infused back into the patient.

                            Brand Name : ET140203

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 17, 2022

                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Eureka Therapeutics

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                            euroPLX 86 Munich
                            Not Confirmed
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                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Announces Publication of Crystal Structure of TCR Mimic Redirected T Cells Targeting Alpha...

                            Details : ET140203 T cells are autologous T cells genetically modified to carry a TCR-mimic (TCRm) construct capable of mediating cell killing by targeting tumor specific intracellular antigens and addressing solid tumor therapy challenges.

                            Brand Name : ET140203

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            August 03, 2022

                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Eureka Therapeutics

                            U.S.A arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : TCR Mimic CAR-T Cell Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Memorial Sloan Kettering Cancer Center

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Announces Publication of Study Demonstrating Broad Anti-Tumor Activity of TCR Mimic-Redire...

                            Details : In the study, anti-NDC80 TCRm-redirected T cells demonstrated high specificity in recognizing and killing multiple cancer cell lines. Moreover, no toxicities to healthy leukocytes and hematopoietic stem cells were observed.

                            Brand Name : NDC80

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            June 06, 2022

                            Lead Product(s) : TCR Mimic CAR-T Cell Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Memorial Sloan Kettering Cancer Center

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Eureka Therapeutics

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                            euroPLX 86 Munich
                            Not Confirmed

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Receives Orphan Drug Designations for Treatment of Hepatocellular Carcinoma (HCC) With ART...

                            Details : The designation for Eureka’s clinical candidate, ET140203, an investigational therapy TCR-mimic antibody to target alpha-fetoprotein peptide/HLA-A2 complex on liver cancer cells underscore the significant unmet medical need for more effective liver can...

                            Brand Name : ET140203

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            February 08, 2022

                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Eureka Therapeutics

                            U.S.A arrow
                            euroPLX 86 Munich
                            Not Confirmed

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : InvisiMask

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Announces Successful Preclinical Results of Invisimask™ Human Antibody Nasal Spray Again...

                            Details : Newly published study reports Invisimask™, a self-administered nasal spray, protects against Sars-Cov-2 infection for up to 10 Hours in mice.

                            Brand Name : InvisiMask

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 14, 2020

                            Lead Product(s) : InvisiMask

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Eureka Therapeutics

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                            euroPLX 86 Munich
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                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Eureka Therapeutics Announces Initiation of ARYA-1 Clinical Trial to Evaluate ET140203 ARTEMIS® T Cell Therap...

                            Details : The ARYA-1 study is a multi-center, open-label, dose escalation clinical trial of ARTEMIS® T cell therapy to initially assess the safety and tolerability of ET140203 T cells in adult patients with AFP-positive HCC and to determine the recommended phase ...

                            Brand Name : ET140203

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 05, 2020

                            Lead Product(s) : ET140203

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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