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    [{"orgOrder":0,"company":"Astellas Pharma","sponsor":"Amgen Inc","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"JAPAN","productType":"Large molecule","year":"2020","type":"Acquisition","leadProduct":"Evolocumab","moa":"Subtilisin\/kexin type 9","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved","graph3":"Astellas Pharma","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Injection","sponsorNew":"Astellas Pharma \/ Amgen","highestDevelopmentStatusID":"12","companyTruncated":"Astellas Pharma \/ Amgen"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Evolocumab","moa":"Subtilisin\/kexin type 9","graph1":"Cardiology\/Vascular 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Applicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"Evolocumab","moa":"Subtilisin\/kexin type 9","graph1":"Genetic Disease","graph2":"Approved","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Amgen Inc \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Amgen Inc \/ Not Applicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"Evolocumab","moa":"PCSK9","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Amgen Inc \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Amgen Inc \/ Not Applicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"Evolocumab","moa":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Injectable\/Injection","sponsorNew":"Amgen Inc \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Amgen Inc \/ Not Applicable"}]

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    Evolocumab

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                            01

                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen to Present New Repatha® (evolocumab) and Olpasiran Data at ACC

                            Details : Repatha (evolocumab) inhibits PCSK9 protein and prevents it from binding to the LDL receptor (LDLR), allowing LDLR to recycle back to the liver. By inhibiting the protein, the drug increases the number of LDLRs to clear from the blood, reducing LDL level...

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 01, 2023

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            New Amgen Data at ESC 2022 Show Long-term LDL-C Lowering With Repatha® (Evolocumab) Was Well-tolerated for Mo...

                            Details : FOURIER is part of Amgen's PROFICIO (Program to Reduce LDL-C and cardiovascular Outcomes Following Inhibition of PCSK9 In different populations) program of clinical studies investigating the impact of Repatha® on LDL-C and CVD across multiple population...

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 29, 2022

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen to Present New Data at ESC Congress 2022 Highlighting Up to 8.5 Years of Repatha® (Evolocumab) Safety a...

                            Details : FOURIER-OLE studies are longest trials with PCSK9i to date, with patients receiving Repatha (evolocumab) for a median of 5 years and some patients receiving Repatha continuously for up to 8.5 years across the FOURIER and OLE study period.

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 22, 2022

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen Announces Results From Two Open Label Extension Studies of Repatha® (Evolocumab)

                            Details : Repatha, a human mAB that inhibits proprotein convertase subtilisin/kexin type 9, showed sustained reduction in LDL-C with no new safety findings in Phase 3 FOURIER cardiovascular outcomes trial.

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 27, 2022

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Amgen Inc

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                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Approves Repatha® (evolocumab) In Pediatric Patients Age 10 And Older With Heterozygous Familial Hypercho...

                            Details : Repatha® (evolocumab) is a human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) for the treatment of homozygous familial hypercholesterolemia (HoFH) for younger pediatric patients.

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 24, 2021

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Amgen Inc

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                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            New Data At ESC Congress 2021 Shows Repatha® Improves Features Of Plaque Stability In Patients With Acute Cor...

                            Details : New positive phase 3 data for repatha in ACS patients who initiated treatment in the acute setting. Repatha in addition to optimized statin therapy improves features of plaque morphology twice as well as statins alone.

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 27, 2021

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Amgen Inc

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                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Efficacy Of Repatha® (Evolocumab) Across High-Risk Patient Populations Reinforced At ACC.21

                            Details : The studies provide the body of evidence for treatment in a variety of high-risk patients and contributed to Repatha being approved in more than 75 countries. Notably, Amgen recently passed the milestone of more than one million patients receiving Repath...

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 11, 2021

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Amgen Inc

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                            Amgen Inc

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            New Amgen Data To Be Presented At ESC Congress 2020 Highlighting Repatha® (evolocumab) Efficacy In High-Risk ...

                            Details : Notable abstracts include data from the first randomized controlled Phase 3 study of a PCSK9 inhibitor, Repatha, in pediatric patients with heterozygous familial hypercholesterolemia (HeFH), which will be presented as a late-breaking abstract in an oral ...

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 25, 2020

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Astellas Pharma

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                            Astellas Pharma

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                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved

                            Sponsor : Amgen Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Amgen Astellas Biopharma to Become a Wholly Owned Amgen Affiliate

                            Details : Amgen Astellas BioPharma and Astellas have worked on Repatha for familial hypercholesterolemia, BLINCYTO and EVENITY. Under acquisition, Amgen Astellas BioPharma will change its name to Amgen K.K., and simultaneously relocate its Headquarters to Tokyo Mi...

                            Brand Name : Repatha

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            January 23, 2020

                            Lead Product(s) : Evolocumab

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved

                            Sponsor : Amgen Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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