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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : SIL-204

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Recipient : Silexion Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : Through the collaboration, Evonik’s proprietary biodegradable long-acting PLGA microparticle formulation will used for SIL-204, Silexion’s siRNA candidate for KRAS mutated Pancreatic cancer.

                          Product Name : SIL-204

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          December 17, 2024

                          Lead Product(s) : SIL-204

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Silexion Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Evonik company banner

                          02

                          Lead Product(s) : Cellulose

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Study Phase : Approved

                          Sponsor : JeNaCell

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : epicite® balance is made of biosynthetic cellulose, a hydropolymer for innovative medical device applications. The dressing enables superior wound cleansing effects and reactivates the healing of slow-healing wounds.

                          Product Name : Epicite® Balance

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 14, 2023

                          Lead Product(s) : Cellulose

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : JeNaCell

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Evonik company banner

                          03

                          Lead Product(s) : Cellulose

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Study Phase : Approved

                          Sponsor : JeNaCell

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : epicite® balance is made of biosynthetic cellulose, a hydropolymer for innovative medical device applications. The dressing enables superior wound cleansing effects and reactivates the healing of slow-healing wounds.

                          Product Name : Epicite® Balance

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 13, 2023

                          Lead Product(s) : Cellulose

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : JeNaCell

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Evonik company banner

                          04

                          Lead Product(s) : Bupivacaine

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Allay Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : ATX-101 is a small product placed directly into the TKA surgical site in a simple, ‘place & go’ manner designed to add minimal extra complexity and time to the procedure.

                          Product Name : ATX-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 13, 2022

                          Lead Product(s) : Bupivacaine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Allay Therapeutics

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Evonik company banner

                          05

                          Details : Vonoprazan is a novel potassium-competitive acid blocker (PCAB). It inhibits gastric acid secretion by acting as a reversible competitive inhibitor against potassium ions.

                          Product Name : Voquezna Triple Pack

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 24, 2022

                          Lead Product(s) : Vonoprazan Fumarate,Amoxicillin Trihydrate,Clarithromycin

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Phathom Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Evonik company banner

                          06

                          Lead Product(s) : mRNA-based Therapy

                          Therapeutic Area : Infections and Infectious Diseases

                          Study Phase : Undisclosed

                          Sponsor : BARDA

                          Deal Size : $220.0 million

                          Deal Type : Funding

                          Details : Lipids, molecules that make up the building blocks of living cells, are critical to producing mRNA-based drugs. The mRNA is enclosed in a lipid nanoparticle (LNP) composed of specific lipids. The LNP protects the mRNA and delivers it safely into the cell...

                          Product Name : Undisclosed

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 02, 2022

                          Lead Product(s) : mRNA-based Therapy

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Undisclosed

                          Sponsor : BARDA

                          Deal Size : $220.0 million

                          Deal Type : Funding

                          Evonik company banner

                          07

                          Lead Product(s) : Simufilam

                          Therapeutic Area : Neurology

                          Study Phase : Phase II

                          Sponsor : Cassava Sciences

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Evonik to supply commercial quantities of simufilam, a drug candidate for the treatment of Alzheimer’s disease. Simufilam is a novel drug, discovered at Cassava Sciences, that targets both neuroinflammation and neurodegeneration.

                          Product Name : PTI-125

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 09, 2021

                          Lead Product(s) : Simufilam

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Cassava Sciences

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Evonik company banner

                          08

                          Lead Product(s) : Tozinameran

                          Therapeutic Area : Infections and Infectious Diseases

                          Study Phase : Approved

                          Sponsor : BioNTech

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : Lipids are fundamental to produce highly effective mRNA-based vaccines. Only with an increase in lipid supply can the volume of vaccine be further increased. This move marks an expansion of the partnership between Evonik and the Comirnaty, vaccine manufa...

                          Product Name : Comirnaty

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          February 11, 2021

                          Lead Product(s) : Tozinameran

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : BioNTech

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Evonik company banner