Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : XOMA
Deal Size : Undisclosed
Deal Type : Acquisition
Kinnate Biopharma to Be Acquired By XOMA Corporation for Up to $2.5879 Per Share
Details : XOMA gains access to KIN-2787 (exarafenib), a potent and selective investigational small molecule pan-RAF inhibitor, being evaluated for BRAF/NRAS-mutated advanced or metastatic solid tumors.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 16, 2024
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : XOMA
Deal Size : Undisclosed
Deal Type : Acquisition
Lead Product(s) : Exarafenib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Pierre Fabre
Deal Size : $30.5 million
Deal Type : Agreement
Kinnate Biopharma Sells Investigational Pan-RAF Inhibitor Exarafenib to Pierre Fabre
Details : Through the agreement, Pierre Fabre will access development and global commercialization of Exarafenib, an investigational pan-RAF inhibitor evaluated for NRAS-mutated melanoma.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
January 03, 2024
Lead Product(s) : Exarafenib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Pierre Fabre
Deal Size : $30.5 million
Deal Type : Agreement
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KIN-2787 (exarafenib) is an orally administered, potent and selective investigational small molecule pan-RAF inhibitor, designed to target BRAF Class II and Class III alterations, it is a potential treatment for NRAS mutation-positive melanoma.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 17, 2023
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Kinnate Biopharma
Deal Size : $24.0 million
Deal Type : Acquisition
Details : KIN-2787, is an orally available small molecule pan-RAF inhibitor being developed for the treatment of patients with lung cancer, melanoma, and other solid tumors.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
February 21, 2023
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Kinnate Biopharma
Deal Size : $24.0 million
Deal Type : Acquisition
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Kinnate Biopharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KIN-2787 (exarafenib), is an orally available small molecule pan-RAF inhibitor being developed for the treatment of patients with lung cancer, melanoma, and other solid tumors.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 21, 2023
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Kinnate Biopharma
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KIN-2787, a pan-RAF inhibitor, achieved meaningful exposures that were dose proportional and exceeded the predicted efficacious thresholds based on preclinical models. KIN-2787 cleared the predicted efficacious dose at 300 mg bid.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 10, 2022
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KIN-2787 is an orally available, potent and selective small molecule pan-RAF inhibitor being evaluated in KN-8701, an ongoing Phase 1 global clinical trial in patients with solid tumors harboring BRAF alterations or who have NRAS mutant melanoma.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
September 21, 2022
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Daily KIN-2787 treatment resulted in tumor growth inhibition in human melanoma xenograft models bearing Class I, II and III BRAF alterations as well as NRAS mutation and was associated with MAPK pathway suppression.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 04, 2022
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : In preclinical studies, KIN-2787, small molecule pan-RAF inhibitor has demonstrated its potential as a promising next-generation RAF inhibitor with unique properties that have demonstrated potent activity against a variety of oncogenic BRAF-driven cancer...
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
August 03, 2022
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KIN-2787 is a promising next-generation RAF inhibitor with demonstrated capabilities in overcoming well-characterized resistance mechanism, also has shown potent activity against a variety of oncogenic BRAF-driven lung cancers in preclinical studies.
Product Name : KIN-2787
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 14, 2022
Lead Product(s) : Exarafenib,Binimetinib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable