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Tablet","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"National Institutes of Health","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ National Institutes of Health","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ National Institutes of Health"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2023","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2020","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Phase III","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2022","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Phase 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Hoffmann-La Roche"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Inapplicable"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2020","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved 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Tablet","sponsorNew":"Exelixis \/ Ipsen","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Ipsen"},{"orgOrder":0,"company":"Exelixis","sponsor":"Iconic Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2020","type":"Agreement","leadProduct":"XB002","moa":"Tissue Factor","graph1":"Oncology","graph2":"Preclinical","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Exelixis \/ Exelixis","highestDevelopmentStatusID":"4","companyTruncated":"Exelixis \/ Exelixis"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody-drug Conjugate","year":"2022","type":"Inapplicable","leadProduct":"XB002","moa":"||Tissue Factor","graph1":"Oncology","graph2":"Phase 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Exelixis","highestDevelopmentStatusID":"2","companyTruncated":"Exelixis \/ Exelixis"},{"orgOrder":0,"company":"Exelixis","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"HPAPI","year":"2020","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Phase III","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Exelixis","highestDevelopmentStatusID":"10","companyTruncated":"Exelixis \/ Exelixis"},{"orgOrder":0,"company":"Exelixis","sponsor":"Ipsen","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"HPAPI","year":"2020","type":"Collaboration","leadProduct":"Cabozantinib","moa":"||MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Phase III","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"Ph 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Exelixis"},{"orgOrder":0,"company":"Exelixis","sponsor":"Ipsen","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FRANCE","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"MET\/VEGFR\/AXL","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Exelixis \/ Exelixis","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Exelixis"},{"orgOrder":0,"company":"Exelixis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Cabozantinib","moa":"MET\/AXL\/RET","graph1":"Oncology","graph2":"Approved FDF","graph3":"Exelixis","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet, Film Coated","sponsorNew":"Exelixis \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Exelixis \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Cabometyx (cabozantinib S-malate) is a oral TK inhibitor which is being investigated in advanced pancreatic neuroendocrine tumors.

                          Product Name : Cabometyx

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 26, 2025

                          Lead Product(s) : Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Cabometyx (cabozantinib S-malate) is a oral TK inhibitor which is being investigated in advanced pancreatic neuroendocrine tumors.

                          Product Name : Cabometyx

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 09, 2025

                          Lead Product(s) : Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : The collaboration combines Exelixis' proven oncology drug development and commercialization track record with Sairopa's expertise. ADU-1805 is currently being evaluated for melanoma.

                          Product Name : 40

                          Product Type : Large molecule

                          Upfront Cash : $40.0 million

                          December 17, 2024

                          Lead Product(s) : ADU-1604

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Sairopa

                          Deal Size : $335.0 million

                          Deal Type : Collaboration

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                          04

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Under the licensing agreement, Exeltis will acquire exclusive rights to market and distribute Theranexus' proprietary product TX01 for treating Gaucher & Niemann-Pick Disease Type C.

                          Product Name : 2.1

                          Product Type : Undisclosed

                          Upfront Cash : $2.1 million

                          December 17, 2024

                          Lead Product(s) : TX01

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Preclinical

                          Recipient : Theranexus

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          05

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Cabometyx (cabozantinib S-malate) is a TK inhibitor which is being investigated in advanced pancreatic neuroendocrine tumors.

                          Product Name : Cabometyx

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : The collaboration aims to evaluate Exelixis’ TKI XL092 (zanzalintinib) with Merck’s Keytruda (pembrolizumab) for HNSCC, and with Welireg (belzutifan), an oral HIF-2 alpha inhibitor, for RCC.

                          Product Name : XL092

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 14, 2024

                          Lead Product(s) : Encoberminogene Rezmadenovec,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Merck & Co

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Cabometyx (cabozantinib S-malate) is a TK inhibitor which is being investigated for the treatment of patients with advanced pancreatic neuroendocrine tumors.

                          Product Name : Cabometyx

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          August 06, 2024

                          Lead Product(s) : Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : The collaboration with Exelixis for the development of Cabometyx (cabozantinib S-malate) in advanced pancreatic neuroendocrine tumors and advanced extra-pancreatic neuroendocrine tumor.

                          Product Name : Cabometyx

                          Product Type : HPAPI

                          Upfront Cash : Undisclosed

                          July 02, 2024

                          Lead Product(s) : Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Ipsen

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : Opdivo (nivolumab) is a programmed death-1 (PD-1) immune checkpoint inhibitor. It is being evaluated in combination with Cabometyx (cabozantinib) for first-line advanced renal cell carcinoma.

                          Product Name : Opdivo

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 22, 2024

                          Lead Product(s) : Nivolumab,Cabozantinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Bristol Myers Squibb

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          ICHH-25
                          Not Confirmed
                          ICHH-25
                          Not Confirmed

                          Details : The companies will enter into a clinical trial collaboration evaluating XL092 (zanzalintinib), a tyrosine kinase inhibitor, in combination with AB521 in patients with advanced solid tumors including clear cell renal cell carcinoma.

                          Product Name : XL092

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 04, 2023

                          Lead Product(s) : Encoberminogene Rezmadenovec,Casdatifan

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Arcus Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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