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Hoffmann-La Roche"},{"orgOrder":0,"company":"Genentech","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Atezolizumab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Genentech","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Genentech \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Genentech \/ Not Applicable"}]

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                            Lead Product(s) : VB10.NEO,Bempegaldesleukin

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Recipient : Nykode Therapeutics

                            Deal Size : $715.0 million

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                            Nykode Therapeutics to Regain Control of VB10.NEO Program

                            Details : Nykode regains control of VB10.NEO cancer vaccine program, a proprietary individualized neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.

                            Brand Name : VB10.NEO

                            Molecule Type : Vaccine

                            Upfront Cash : $200.0 million

                            November 08, 2024

                            Lead Product(s) : VB10.NEO,Bempegaldesleukin

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Nykode Therapeutics

                            Deal Size : $715.0 million

                            Deal Type : Termination

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                            Lead Product(s) : Trontinemab

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Patient Death Prompts Roche to Adjust Alzheimer's Trial

                            Details : RG6102 (trontinemab) is a novel Brainshuttle Aβ antibody specifically engineered for enhanced access to the brain to enable rapid reduction of amyloid in people with AD.

                            Brand Name : RG6102

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 30, 2024

                            Lead Product(s) : Trontinemab

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed
                            • fda
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                            • WHO-GMP
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                            Lead Product(s) : Alectinib Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche’s Alecensa Receives NICE Recommendation to Treat ALK-Positive Lung Cancer

                            Details : Alecensa (alectinib) is an ALK tyrosine kinase receptor inhibitor, approved by NICE authority for treating patients with ALK-positive early-stage NSCLC.

                            Brand Name : Alecensa

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 21, 2024

                            Lead Product(s) : Alectinib Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Genentech

                            U.S.A arrow
                            Antibody Engineering
                            Not Confirmed

                            Genentech

                            U.S.A arrow
                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Faricimab

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Genentech’s Vabysmo Benefits Underrepresented DME Patients

                            Details : Vabysmo (faricimab) is a vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) inhibitor indicated for the treatment of patients with Diabetic Macular Edema.

                            Brand Name : Vabysmo

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 18, 2024

                            Lead Product(s) : Faricimab

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : RO7617991,Tocilizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche MAGE-A4 Trial Withdrawn After Strategic Review

                            Details : RO7617991 is a MAGEA4 inhibitor antibody candidate, being evaluated for treatment of patients with locally advanced or metastatic MAGE-A4-positive solid tumors.

                            Brand Name : RO7617991

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 18, 2024

                            Lead Product(s) : RO7617991,Tocilizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Chugai Pharmaceutical

                            Japan arrow
                            Antibody Engineering
                            Not Confirmed

                            Chugai Pharmaceutical

                            Japan arrow
                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Risdiplam

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Recipient : F. Hoffmann-La Roche

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Evrysdi Two-Year Data in SMA: Most Children Can Sit, Stand, and Walk Independently

                            Details : Evrysdi (risdiplam) is a survival of motor neuron 2 (SMN2) splicing modifier, which is being evaluated for the treatment of infants with pre-symptomatic spinal muscular atrophy.

                            Brand Name : Evrysdi

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 14, 2024

                            Lead Product(s) : Risdiplam

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Recipient : F. Hoffmann-La Roche

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Genentech

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                            Antibody Engineering
                            Not Confirmed

                            Genentech

                            U.S.A arrow
                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Inavolisib,Palbociclib,Fulvestrant

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Approves Genentech’s Itovebi For Advanced Hormone Receptor-Positive Breast Cancer

                            Details : Itovebi (inavolisib) is a PI3K alpha Inhibitor in combination with palbociclib and fulvestran, approved for adults with endocrine-resistant, PIK3CA-mutated HR+/HER2-breast Cancer.

                            Brand Name : Itovebi

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 10, 2024

                            Lead Product(s) : Inavolisib,Palbociclib,Fulvestrant

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed

                            F. Hoffmann-La Roche

                            Switzerland arrow
                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Zolbetuximab,Oxaliplatin,Capecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Roche CE Certification for VYLOY Diagnostic in Gastric and Gastroesophageal Cancer

                            Details : Vyloy (zolbetuximab), a CLDN 18.2 inhibitor has been approved in combination with chemotherapy for patients with HER2-negative, CLDN18.2 positive, unresectable, advanced or recurrent gastric cancer.

                            Brand Name : Vyloy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 10, 2024

                            Lead Product(s) : Zolbetuximab,Oxaliplatin,Capecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Genentech

                            U.S.A arrow
                            Antibody Engineering
                            Not Confirmed

                            Genentech

                            U.S.A arrow
                            Antibody Engineering
                            Not Confirmed
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                            Lead Product(s) : Obinutuzumab,Prednisone,Methylprednisolone

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Positive Phase III Results for Gazyva Show Superiority in Lupus Nephritis Treatment

                            Details : Gazyva (obinutuzumab) is a humanized mAb designed to attach to CD20, being developed for people with active lupus nephritis.

                            Brand Name : Gazyva

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 26, 2024

                            Lead Product(s) : Obinutuzumab,Prednisone,Methylprednisolone

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Chugai Pharmaceutical

                            Japan arrow
                            Antibody Engineering
                            Not Confirmed

                            Chugai Pharmaceutical

                            Japan arrow
                            Antibody Engineering
                            Not Confirmed
                            • fda
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                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Alectinib Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Chugai's Alecensa Approved in Japan for Adjuvant Treatment in Early-Stage ALK+ NSCLC

                            Details : Alecensa (alectinib) is an ALK tyrosine kinase receptor inhibitor, approved y MHLW authority for treating patients with ALK-positive early-stage NSCLC.

                            Brand Name : Alecensa

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 29, 2024

                            Lead Product(s) : Alectinib Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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