Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Positive Data from Phase 1 BEXMAB Study in Higher-Risk MDS and r/r AML
Details : FP-1305 (bexmarilimab) is a first-in-class, humanized mAb that binds to Clever-1, an immunosuppressive receptor on macrophages, being evaluated for high-risk myelodysplastic syndrome.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 18, 2024
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
BEXMAB Data Analysis Provides Insights into HMA-Failed MDS Patient Profiles
Details : FP-1305 (bexmarilimab) is a monoclonal antibody binding to Clever-1, currently in phase 1/2 for treating acute myeloid leukemia, myelodysplastic syndromes, and chronic myelomonocytic leukemia.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 25, 2024
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Faron Doses First HMA-failed MDS Patient with Bexmarilimab in BEXMAB Trial
Details : FP-1305 (bexmarilimab), a CLEVER-1 binder, is in Phase 1/2 trials with azacitidine and venetoclax for treating acute myeloid leukemia, myelodysplastic syndromes, and chronic myelomonocytic leukemia.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 09, 2024
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Insider information: Faron Initiates Phase 2 Part of BEXMAB Study of Bexmarilimab in HMA-failed MDS
Details : FP-1305 (bexmarilimab) binds to Clever-1, an immunosuppressive receptor found on macrophages leading to tumor growth and metastases, which is investigated for the treatment of relapsed/refractory AML and HMA-refractory MmDS patients.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 06, 2023
Lead Product(s) : Bexmarilimab,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FP-1305 (bexmarilimab) binds to Clever-1, an immunosuppressive receptor found on macrophages leading to tumor growth and metastases, which is investigated for the treatment of relapsed/refractory AML and HMA-refractory MmDS patients.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
October 11, 2023
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Faron Receives FDA Orphan Drug Designation for Bexmarilimab in Acute Myeloid Leukemia
Details : U.S. FDA has granted Orphan Drug Designation to Faron Pharmaceuticals' wholly owned asset bexmarilimab, for the treatment of acute myeloid leukemia. ODD will further help bexmarilimab program by offering clinical development and commercialization benefit...
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
August 29, 2023
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FP-1305 (bexmarilimab) binds to Clever-1, an immunosuppressive receptor found on macrophages leading to tumor growth and metastases (i.e. helps cancer evade the immune system).
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 19, 2023
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FP-1305 (bexmarilimab) is Faron's wholly-owned, investigative precision immunotherapy with the potential to provide permanent immune stimulation for difficult-to-treat cancers through targeting myeloid cell function.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 16, 2022
Lead Product(s) : Bexmarilimab,Azacitidine
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Of 11 patients, 4 experienced clinical benefit - 1 patient had a partial response after two cycles of bexmarilimab (tumor growth reduced by 40% from baseline) but was discontinued before a confirmatory scan was performed. 3 patients had stable disease.
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 21, 2022
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The conclusion from analysis is that, when used together, IFNy and TNFa are highly predictive of response to bexmarilimab (P < 0.0001), and patients with low IFNy and TNFa levels experienced significantly higher clinical benefit following treatment with ...
Brand Name : FP-1305
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 09, 2022
Lead Product(s) : Bexmarilimab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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