[{"orgOrder":0,"company":"Orion Corporation","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FINLAND","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Darolutamide","moa":"Androgen receptor","graph1":"Oncology","graph2":"Approved","graph3":"Orion Corporation","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Orion Corporation \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orion Corporation \/ Not Applicable"},{"orgOrder":0,"company":"Orion Corporation","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FINLAND","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Darolutamide","moa":"Androgen receptor","graph1":"Oncology","graph2":"Approved","graph3":"Orion 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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Study Phase : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : FZ008-145 is a highly selective second-generation Nav1.8 inhibitor, offering powerful, non-addictive pain relief advantages. It is being evaluated in preclinical studies for acute and chronic pain.

                          Brand Name : FZ008-145

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 10, 2024

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          fermion

                          02

                          Lead Product(s) : Trilaciclib,Irinotecan Hydrochloride,Oxaliplatin

                          Therapeutic Area : Oncology

                          Study Phase : Approved

                          Sponsor : G1 Therapeutics, Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : The FDA approved COSELA™ (trilaciclib) as the first and only myeloprotection therapy to decrease the incidence of chemotherapy-induced myelosuppression.

                          Brand Name : Cosela

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 12, 2021

                          Lead Product(s) : Trilaciclib,Irinotecan Hydrochloride,Oxaliplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : G1 Therapeutics, Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          fermion

                          03

                          Details : Orion will continue to developtwo bispecific antibodies, which are currently in late-stage pre-clinical development, successfully developed using Alligator’s RUBY bispecific format.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          November 19, 2024

                          Lead Product(s) : Bispecific Antibody

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : Alligator Bioscience

                          Deal Size : $3.6 million

                          Deal Type : Collaboration

                          Fermion Orion Company Banner

                          04

                          Details : ODM-111 is NaV. 1.8 blocker was being evaluated in the early-stage clinical trial studies with the patients for the treatment of acute and chronic pain.

                          Brand Name : ODM-111

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 24, 2024

                          Lead Product(s) : ODM-111

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          05

                          Details : Nubeqa (darolutamide) is an orally available androgen receptor inhibitors, which is currently being evaluated for the treatment of metastatic hormone-sensitive prostate cancer.

                          Brand Name : Nubeqa

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 14, 2024

                          Lead Product(s) : Darolutamide,Androgen Deprivation Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bayer AG

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          06

                          Details : Nubeqa (darolutamide) is an orally available androgen receptor inhibitors, which is currently being evaluated in combination with ADT for metastatic hormone-sensitive prostate cancer.

                          Brand Name : Nubeqa

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 26, 2024

                          Lead Product(s) : Darolutamide,Androgen Deprivation-based Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bayer AG

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          07

                          Details : Through the collaboration, Orion and Aitia will work together to discover and validate novel drug targets and to develop drug candidates across multiple oncologic indications.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 25, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Aitia

                          Deal Size : $10.0 million

                          Deal Type : Collaboration

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                          08

                          Details : Through the license agreement, Merck will gain global rights to develop and commercialize MK-5684 (opevesostat), which is being evaluated for metastatic castration-resistant prostate cancer.

                          Brand Name : MK-5684

                          Molecule Type : Small molecule

                          Upfront Cash : $290.0 million

                          July 01, 2024

                          Lead Product(s) : Opevesostat,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : $1,920.0 million

                          Deal Type : Licensing Agreement

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                          09

                          Details : Under the license agreement, Tenax will be developing and commercializing the TNX-103 (levosimendan) for the treatment of pulmonary hypertension with heart failure with preserved ejection fraction.

                          Brand Name : TNX-103

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 20, 2024

                          Lead Product(s) : Levosimendan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Recipient : Tenax Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          10

                          Details : The net proceeds will be used to advance Lego's ADC pipeline including, LCB14, an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2).

                          Brand Name : LCB14

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 16, 2024

                          Lead Product(s) : LCB14

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : LegoChem Biosciences

                          Deal Size : $410.9 million

                          Deal Type : Financing

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