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                          Top Deals by Deal Size (USD bn)

                          01

                          Details : Through the collaboration, Orion and Aitia will work together to discover and validate novel drug targets and to develop drug candidates across multiple oncologic indications.

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 25, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Aitia

                          Deal Size : $10.0 million

                          Deal Type : Collaboration

                          Fermion Orion Company Banner

                          02

                          Details : Through the license agreement, Merck will gain global rights to develop and commercialize MK-5684 (opevesostat), which is being evaluated for metastatic castration-resistant prostate cancer.

                          Brand Name : MK-5684

                          Molecule Type : Small molecule

                          Upfront Cash : $290.0 million

                          July 01, 2024

                          Lead Product(s) : Opevesostat,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : $1,920.0 million

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          03

                          Details : Under the license agreement, Tenax will be developing and commercializing the TNX-103 (levosimendan) for the treatment of pulmonary hypertension with heart failure with preserved ejection fraction.

                          Brand Name : TNX-103

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 20, 2024

                          Lead Product(s) : Levosimendan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Recipient : Tenax Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          04

                          Details : The net proceeds will be used to advance Lego's ADC pipeline including, LCB14, an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2).

                          Brand Name : LCB14

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 16, 2024

                          Lead Product(s) : LCB14

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : LegoChem Biosciences

                          Deal Size : $410.9 million

                          Deal Type : Financing

                          Fermion Orion Company Banner

                          05

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Study Phase : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Details : FZ008-145 is a highly selective second-generation Nav1.8 inhibitor, offering powerful, non-addictive pain relief advantages. It is being evaluated in preclinical studies for acute and chronic pain.

                          Brand Name : FZ008-145

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 10, 2024

                          Lead Product(s) : FZ008-145

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          fermion

                          06

                          Details : Under the agreement, Orion gains access to Glykos’ proprietary ADC technologies, initiating an ADC program and will be responsible for the target selection, research, development, and commercialization of up to three next-generation ADCs, with a focus ...

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 08, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Recipient : Glykos

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          07

                          Details : ODM-208/MK5684 is an investigational CYP11A1 inhibitor, which is being evaluated in combination with hormone replacement therapy under phase 3 clinical trials for the treatment of metastatic castration-resistant prostate cancer (mCRPC).

                          Brand Name : ODM-208

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 05, 2024

                          Lead Product(s) : MK5684,Dexamethasone,Fludrocortisone Acetate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          08

                          Details : ODM-208 (or MK-5684) is an investigational oral, non-steroidal and selective inhibitor of the CYP11A1 enzyme discovered and developed by Orion for the treatment of hormone-dependent cancers, such as metastatic castration-resistant prostate cancer.

                          Brand Name : ODM-208

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 21, 2023

                          Lead Product(s) : MK-5684,Dexamethasone,Hydrocortisone

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner

                          09

                          Details : The agreement aims for the exclusive right to package, distribute, market and sell Suvexx, a patent protected, fixed dose combination of naproxen sodium and sumatriptan approved for the acute treatment of migraine attacks in adults, in all remaining E.U....

                          Brand Name : Suvexx

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 15, 2023

                          Lead Product(s) : Naproxen Sodium,Sumatriptan

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Recipient : Nuvo Pharmaceuticals

                          Deal Size : $0.6 million

                          Deal Type : Licensing Agreement

                          Fermion Orion Company Banner

                          10

                          Details : Ztalmy (ganaxolone) is a positive allosteric modulation of the gamma-aminobutyric acid type A (GABAA) receptor in the CNS. It is used for the treatment of epileptic seizures associated with CDKL5 deficiency disorder.

                          Brand Name : Ztalmy

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 31, 2023

                          Lead Product(s) : Ganaxolone

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved

                          Sponsor : Marinus Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

                          Fermion Orion Company Banner