[{"orgOrder":0,"company":"Forbion","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"PJS-539","moa":"SARS-CoV-2 replication","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Forbion","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral","sponsorNew":"Forbion \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Forbion \/ Not Applicable"},{"orgOrder":0,"company":"Forbion","sponsor":"Anaveon","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Series B Financing","leadProduct":"ANV419","moa":"IL-2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Forbion","amount2":0.12,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.12,"dosageForm":"Intravenous Infusion","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"7","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"ARMGO Pharma","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2021","type":"Series B Financing","leadProduct":"ARM210","moa":"","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Forbion","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0.040000000000000001,"dosageForm":"Oral","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"8","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"F2G Limited","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2022","type":"Financing","leadProduct":"Olorofim","moa":"DHODH","graph1":"Infections and Infectious Diseases","graph2":"Phase III","graph3":"Forbion","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0.070000000000000007,"dosageForm":"Tablet","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"10","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"Noema Pharma","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2023","type":"Series B Financing","leadProduct":"Basimglurant","moa":"","graph1":"Neurology","graph2":"Phase II\/ Phase III","graph3":"Forbion","amount2":0.11,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Neurology","amount2New":0.11,"dosageForm":"","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"9","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"Kynexis Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2023","type":"Series A Financing","leadProduct":"KYN-5356","moa":"","graph1":"Neurology","graph2":"Phase I","graph3":"Forbion","amount2":0.059999999999999998,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0.059999999999999998,"dosageForm":"","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"6","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"Calluna Pharma","pharmaFlowCategory":"D","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"","productType":"Large molecule","year":"2024","type":"Series A Financing","leadProduct":"CAL101","moa":"","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase I","graph3":"Forbion","amount2":0.080000000000000002,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0.080000000000000002,"dosageForm":"","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"6","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"SynOx Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Series B Financing","leadProduct":"Emactuzumab","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Forbion","amount2":0.080000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.080000000000000002,"dosageForm":"Infusion","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"10","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"Progentos Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Series A Financing","leadProduct":"Undisclosed","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"Forbion","amount2":0.070000000000000007,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0.070000000000000007,"dosageForm":"","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"5","companyTruncated":"Forbion \/ Forbion"},{"orgOrder":0,"company":"Forbion","sponsor":"LoQus23 Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2024","type":"Series A Financing","leadProduct":"Undisclosed","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Forbion","amount2":0.040000000000000001,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Forbion \/ Forbion","highestDevelopmentStatusID":"14","companyTruncated":"Forbion \/ Forbion"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The proceeds from the financing will be primarily used to support the pre-clinical development and initial clinical studies of LoQus23's lead program, an allosteric small molecule MutSβ inhibitor.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 02, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Recipient : LoQus23 Therapeutics

                          Deal Size : $43.0 million

                          Deal Type : Series A Financing

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The financing aims to fund the Progentos, which is developing first-in-class small molecules designed to induce remyelination of axons affected by multiple sclerosis.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 20, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Recipient : Progentos Therapeutics

                          Deal Size : $65.0 million

                          Deal Type : Series A Financing

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The proceeds will be used to advance late-stage product Emactuzumab, SynOx's potentially best-in-class CSF-1(R) inhibiting monoclonal antibody for the treatment of Tenosynovial Giant Cell Tumour.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 22, 2024

                          Lead Product(s) : Emactuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : SynOx Therapeutics

                          Deal Size : $75.0 million

                          Deal Type : Series B Financing

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Calluna Pharma focuses on the clinical stage lead program CAL101, which is a monoclonal antibody that neutralizes the bioactivity of S100A4 & implements DAMP protein for idiopathic pulmonary fibrosis.

                          Brand Name : CAL101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          January 22, 2024

                          Lead Product(s) : Idelalisib

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Recipient : Calluna Pharma

                          Deal Size : $81.1 million

                          Deal Type : Series A Financing

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Through the proceeds, Kynexis will advance its lead therapeutic candidate, KYN-5356, a potential first-in-class KAT-II inhibitor for the treatment of cognitive impairment associated with schizophrenia (CIAS), toward clinical development.

                          Brand Name : KYN-5356

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 07, 2023

                          Lead Product(s) : KYN-5356

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Recipient : Kynexis Therapeutics

                          Deal Size : $62.1 million

                          Deal Type : Series A Financing

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The proceeds of the Series B financing will be used to advance Noema Pharma's clinical-stage assets including its lead compound NOE-101 (basimglurant), an mGluR5 inhibitor which is being evaluated in Phase 2b clinical trials for severe pain in TN and sei...

                          Brand Name : NOE-101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 07, 2023

                          Lead Product(s) : Basimglurant

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II/ Phase III

                          Recipient : Noema Pharma

                          Deal Size : $112.0 million

                          Deal Type : Series B Financing

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : The proceeds from the financing with Shionogi & Co., Ltd., will enable F2G to advance late-stage development and commercialization in the US of F901318 (olorofim), a novel oral antifungal therapy to treat invasive aspergillosis and other rare mold infect...

                          Brand Name : F901318

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 04, 2022

                          Lead Product(s) : Olorofim

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Recipient : F2G Limited

                          Deal Size : $70.0 million

                          Deal Type : Financing

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Proceeds will fund further clinical development of its lead asset, ARM210, for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT) as well as other cardiac and skeletal muscle indications.

                          Brand Name : S48168

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 20, 2021

                          Lead Product(s) : ARM210

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Recipient : ARMGO Pharma

                          Deal Size : $35.0 million

                          Deal Type : Series B Financing

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Proceeds from this financing will enable the Company to pursue multiple parallel Phase II programs in order to explore the full therapeutic potential of ANV419. ANV419, is designed to signal through the IL-2 beta/gamma receptor and overcome known challen...

                          Brand Name : ANV419

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          December 16, 2021

                          Lead Product(s) : ANV419

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Anaveon

                          Deal Size : $119.6 million

                          Deal Type : Series B Financing

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : PJS-539 is a potent, once daily, oral pill that inhibits attachment, infection and replication of SARS-CoV-2 and other RNA viruses to treat COVID-19.

                          Brand Name : PJS-539

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 06, 2021

                          Lead Product(s) : PJS-539

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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