Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : FBX-101
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Forge Biologics Reports FBX-101 Update in Krabbe Disease Identified by Newborn Screening
Details : FBX-101 is an adeno-associated viral serotype rh10 (AAVrh10) gene therapy. It is being evaluated in phase 1/2 clinical trials for the treatment of Krabbe Disease.
Brand Name : FBX-101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
January 29, 2024
Lead Product(s) : FBX-101
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Undisclosed
Therapeutic Area : Ophthalmology
Study Phase : Preclinical
Sponsor : Life Biosciences
Deal Size : Undisclosed
Deal Type : Partnership
Details : Forge will help to advance Life Bio’s partial epigenetic reprogramming platform to address aging-related diseases, including its lead program targeting ophthalmic indications by providing cGMP manufacturing and development services for its novel AAV ge...
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
May 08, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Ophthalmology
Highest Development Status : Preclinical
Sponsor : Life Biosciences
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : FBX-101
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FBX-101 is an adeno-associated viral serotype rh10 gene therapy which delivers a functional copy of the GALC gene to cells in both the CNS and PNS. It has been shown to functionally correct the central and peripheral neuropathy associated with krabbe.
Brand Name : FBX-101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
January 17, 2023
Lead Product(s) : FBX-101
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ET-101
Therapeutic Area : Neurology
Study Phase : Preclinical
Recipient : Eikonoklastes Therapeutics
Deal Size : Undisclosed
Deal Type : Partnership
Details : The partnership will advance Eikonoklastes’ AAV-based gene therapy, ET-101, into clinical trials for the treatment of patients with amyotrophic lateral sclerosis (ALS).
Brand Name : ET-101
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
November 29, 2022
Lead Product(s) : ET-101
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Recipient : Eikonoklastes Therapeutics
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : AAVrh.10-hGALC
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Subjects treated with FBX-101 (AAVrh.10-hGALC) have shown increased galactocerebrosidase (GALC) enzyme activity in plasma and cerebrospinal fluid (CSF), normal white matter myelination and normalization of motor development in two children 90 days and 9 ...
Brand Name : FBX-101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 11, 2022
Lead Product(s) : AAVrh.10-hGALC
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : RTx-015
Therapeutic Area : Genetic Disease
Study Phase : IND Enabling
Recipient : Ray Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Forge will provide research-grade and GMP-Pathway plasmid manufacturing services, in addition to adeno-associated viral vector (AAV) process development, scale-up engineering, and cGMP manufacturing services for Ray Therapeutics’ program, RTx-015.
Brand Name : RTx-015
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 10, 2022
Lead Product(s) : RTx-015
Therapeutic Area : Genetic Disease
Highest Development Status : IND Enabling
Recipient : Ray Therapeutics
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : AAV-based TMPRSS3 Gene Therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Study Phase : IND Enabling
Sponsor : Myrtelle
Deal Size : Undisclosed
Deal Type : Partnership
Myrtelle and Forge Biologics Announce Viral Vector and Plasmid DNA cGMP Manufacturing Partnership
Details : Forge will provide research-grade and GMP-Pathway plasmid manufacturing services as well as cGMP adeno-associated viral (AAV) process development and scale-up manufacturing services for Myrtelle’s program, Myr-201 (gene therapy delivery of a therapeuti...
Brand Name : Myr-201
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
October 03, 2022
Lead Product(s) : AAV-based TMPRSS3 Gene Therapy
Therapeutic Area : Otolaryngology (Ear, Nose, Throat)
Highest Development Status : IND Enabling
Sponsor : Myrtelle
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : AAV-based Gene Therapy
Therapeutic Area : Technology
Study Phase : Undisclosed
Sponsor : Drive Capital
Deal Size : $90.0 million
Deal Type : Series C Financing
Details : The Company will use the funding to expand client offerings, including proprietary technologies, manufacturing systems, cell lines, and additional services to bolster its end-to-end manufacturing platform.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
September 12, 2022
Lead Product(s) : AAV-based Gene Therapy
Therapeutic Area : Technology
Highest Development Status : Undisclosed
Sponsor : Drive Capital
Deal Size : $90.0 million
Deal Type : Series C Financing
Lead Product(s) : AAVrh.10-hGALC
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : FBX-101 is an adeno-associated viral serotype rh10 (AAVrh.10-hGALC) gene therapy that is typically delivered after a hematopoietic stem cell transplant. FBX-101 delivers a functional copy of the GALC gene to cells in both the central and peripheral nervo...
Brand Name : FBX-101
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
August 30, 2022
Lead Product(s) : AAVrh.10-hGALC
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Ray-001
Therapeutic Area : Genetic Disease
Study Phase : Preclinical
Recipient : Ray Therapeutics
Deal Size : Undisclosed
Deal Type : Partnership
Details : Ray-001 is intended for use in treating patients with retinitis pigmentosa (RP). Optogenetics is a promising approach that has the potential to restore useful vision to visually-impaired and blind individuals.
Brand Name : Ray-001
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
March 01, 2022
Lead Product(s) : Ray-001
Therapeutic Area : Genetic Disease
Highest Development Status : Preclinical
Recipient : Ray Therapeutics
Deal Size : Undisclosed
Deal Type : Partnership
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