[{"orgOrder":0,"company":"Galapagos","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"BELGIUM","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Ziritaxestat","moa":"Autotaxin","graph1":"Immunology","graph2":"Phase II","graph3":"Galapagos","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Film Coated Tablet","sponsorNew":"Galapagos \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Galapagos \/ Not Applicable"},{"orgOrder":0,"company":"Galapagos","sponsor":"Ryvu Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"POLAND","productType":"Small molecule","year":"2020","type":"Licensing 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Galapagos"},{"orgOrder":0,"company":"Galapagos","sponsor":"BridGene Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Galapagos","amount2":0.16,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Galapagos \/ Galapagos","highestDevelopmentStatusID":"14","companyTruncated":"Galapagos \/ Galapagos"},{"orgOrder":0,"company":"Galapagos","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"GLPG5101","moa":"","graph1":"Technology","graph2":"Phase 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                          01

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : GLPG5101 is an IV infused, second generation anti-CD19/4-1BB CAR-T product candidate. Currently being assessed in patients with relapsed/refractory non-Hodgkin lymphoma.

                          Brand Name : GLPG5101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 23, 2024

                          Lead Product(s) : GLPG5101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : The collaboration aims to advance the molecule into a preclinical candidate for the treatment of cancer with Galapagos holding exclusive rights for further development and commercialization.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 01, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : BridGene Biosciences

                          Deal Size : $159.0 million

                          Deal Type : Collaboration

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                          03

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Galapagos will have the option to license Adaptimmune’s next-generation TCR T-cell therapy (uza-cel) targeting MAGE-A4 for head & neck cancer and potential future solid tumor indications.

                          Brand Name : ADP-A2M4CD8

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $70.0 million

                          May 30, 2024

                          Lead Product(s) : Uzatresgene Autoleucel,Nivolumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Adaptimmune Therapeutics

                          Deal Size : $565.0 million

                          Deal Type : Collaboration

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                          04

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Alfasigma completed acquisition of Jyseleca (filgotinib), which provides European and UK Marketing Authorizations. It is used for the treatment of moderate to severe rheumatoid arthritis.

                          Brand Name : Jyseleca

                          Molecule Type : Small molecule

                          Upfront Cash : $54.3 million

                          January 31, 2024

                          Lead Product(s) : Filgotinib

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Alfasigma

                          Deal Size : $184.9 million

                          Deal Type : Acquisition

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                          05

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Thermo Fisher will provide GMP manufacturing, BioServices, and Specialty Logistics for Galapagos’ CAR-T hemato-oncology clinical program, GLPG-5101, developed for Non-Hodgkin’s lymphoma treatment.

                          Brand Name : GLPG-5101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 04, 2024

                          Lead Product(s) : GLPG-5101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : Thermo Fisher Scientific

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Galapagos and BridGene will collaborate to develop precision oncology medicines by combining Galapagos' small molecule expertise with BridGene's proprietary IMTAC™ chemoproteomics platform.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          January 03, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : BridGene Biosciences

                          Deal Size : $727.0 million

                          Deal Type : Collaboration

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                          07

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Galapagos transfers Jyseleca (filgotinib) to Alfasigma as part of its transformation into a biotech company focused on immunology and oncology, marking a significant milestone for the company.

                          Brand Name : Jyseleca

                          Molecule Type : Small molecule

                          Upfront Cash : $54.7 million

                          January 02, 2024

                          Lead Product(s) : Filgotinib

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved

                          Sponsor : Alfasigma

                          Deal Size : $229.7 million

                          Deal Type : Agreement

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                          08

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : GLPG5301 is an autologous, second-generation/4-1BB B-cell maturation antigen (BCMA)-directed CAR-T product candidate which is under phase 1/2 clinical development for the treatment of relapsed/refractory multiple myeloma.

                          Brand Name : GLPG5301

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 19, 2023

                          Lead Product(s) : GLPG5301

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : Under the terms of the agreement, Landmark Bio will perform GMP manufacturing of clinical trial batches of Galapagos' development programs of chimeric antigen receptor (CAR) T-cell therapies in hematology-oncology in the Boston metropolitan area.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          November 06, 2023

                          Lead Product(s) : CAR T-cell Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Recipient : Landmark Bio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          10

                          American Pharma Summit
                          Not Confirmed
                          American Pharma Summit
                          Not Confirmed

                          Details : GLPG3667 is an investigational, novel, oral, reversible, and selective tyrosine kinase 2 (TYK2) inhibitor and currently in development for the treatment of inflammatory and auto-immune diseases such as systemic lupus erythematosus.

                          Brand Name : GLPG3667

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 28, 2023

                          Lead Product(s) : GLPG3667

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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