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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Aprepitant

                          Therapeutic Area : Gastroenterology

                          Study Phase : Phase I

                          Sponsor : Oxilio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Quotient has prior experience of working with the Nuformix NXP-001 co-crystal and previously developed a capsule and a powder for oral suspension formulation of Aprepitant, evaluating its performance in a relative bioavailability study versus EMEND.

                          Product Name : NXP-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 02, 2022

                          Lead Product(s) : Aprepitant

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Oxilio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Quotient

                          02

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : PALI-2108, an orally administered, colon-specific phosphodiesterase-4 (PDE4) inhibitor prodrug is in development for patients with ulcerative colitis (UC).

                          Product Name : PALI-2108

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 09, 2025

                          Lead Product(s) : PALI-2108

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : SPY003 is an investigational half-life extended anti-IL-23 monoclonal antibody, which is currently being evaluated for the treatment of inflammatory bowel disease.

                          Product Name : SPY003

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 27, 2025

                          Lead Product(s) : SPY003

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : Through the acquisition, Lilly will leverage FXR program of Organovo, which includes FXR314, it is being evaluated for the treatment of Inflammatory Bowel Disease.

                          Product Name : FXR314

                          Product Type : Other Small Molecule

                          Upfront Cash : $10.0 million

                          February 25, 2025

                          Lead Product(s) : FXR314

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Eli Lilly

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          05

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : IMU-856 is an orally available and systemically acting small molecule modulator that targets SIRT6. It is being evaluated for celiac disease.

                          Product Name : IMU-856

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 20, 2025

                          Lead Product(s) : IMU-856

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : ISM5411 is a novel gut-restricted and PHD specific Inhibitor, beig investigated for the treatment for Inflammatory Bowel Disease (IBD).

                          Product Name : ISM5411

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 07, 2025

                          Lead Product(s) : ISM5411

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : SPY002-091 is an investigational, extended half-life monoclonal antibody targeting TL1A for the potential treatment of inflammatory and fibrotic diseases including IBD.

                          Product Name : SPY002-091

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : SPY002-091

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : The proceeds will support the clinical advancement of FB102, a proprietary anti-CD122 monoclonal antibody therapeutic candidate with potentially broad autoimmune and autoimmune-related indications.

                          Product Name : FB-102

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          November 20, 2024

                          Lead Product(s) : FB-102

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : OrbiMed Advisors

                          Deal Size : $53.0 million

                          Deal Type : Private Placement

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                          09

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Gastroenterology

                          Study Phase : Phase I

                          Sponsor : Children’s Hospital Capital institute of Pediatrics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

                          Details : The partnership aims to develop innovative treatments for Esophageal Atresia (EA) using our flagship Cellspan Esophageal Implant (CEI) product candidate.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          October 28, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Children’s Hospital Capital institute of Pediatrics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          10

                          Cophex
                          Not Confirmed
                          Cophex
                          Not Confirmed

                          Details : VTP-1000 is an investigational, injectable antigen-specific tolerance immunotherapy that utilizes Barinthus Bio’s platform. Currently, it is being evaluated for the treatment of celiac disease.

                          Product Name : VTP-1000

                          Product Type : Vaccine

                          Upfront Cash : Inapplicable

                          September 24, 2024

                          Lead Product(s) : VTP-1000

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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