Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Bitopertin
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Recipient : Disc medicine
Deal Size : $175.0 million
Deal Type : Merger
Disc Medicine Announces Completion of Merger with Gemini Therapeutics
Details : Disc Medicine (bitopertin) is an oral, selective inhibitor of glycine transporter 1. is developing bitopertin as the potentially first disease-modifying therapy to treat erythropoietic porphyrias – a family of rare, genetic disorders caused by dysregul...
Brand Name : DISC-1459
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 29, 2022
Lead Product(s) : Bitopertin
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Recipient : Disc medicine
Deal Size : $175.0 million
Deal Type : Merger
Lead Product(s) : GEM103,Aflibercept
Therapeutic Area : Ophthalmology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The team’s ability to overenroll the study highlights the unmet need and the potential for GEM103 to address these suboptimal outcomes in the setting of regular anti-VEGF therapy and its subsequent depletion in CFH levels causing complement dysfunction...
Brand Name : GEM103
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 13, 2021
Lead Product(s) : GEM103,Aflibercept
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ReGAtta is a dose escalation trial of GEM103, a recombinant human complement factor H (CFH), in dry AMD patients with CFH loss-of-function gene variants.
Brand Name : GEM103
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 10, 2021
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ReGAtta is a dose escalation trial of GEM103, in dry AMD patients with CFH loss-of-function gene variants. GEM103 targets a genetically-defined subset of age-related macular degeneration (AMD) patients with complement dysregulation.
Brand Name : GEM103
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 01, 2021
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Recombinant human complement Factor H
Therapeutic Area : Ophthalmology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Gemini Therapeutics Announces GEM103 Meets All Endpoints in Phase 1 Clinical Study
Details : Results showed that, in the four ascending single IVT doses tested (50, 100, 250 and 500 µg of GEM103 in a 50µL dose volume), there were no inflammation, anti-drug antibody, or treatment-related adverse events. A single intravitreal injection of GEM103...
Brand Name : GEM103
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 13, 2020
Lead Product(s) : Recombinant human complement Factor H
Therapeutic Area : Ophthalmology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Study Phase : Phase I
Sponsor : FS Development Corp
Deal Size : $216.0 million
Deal Type : Merger
Details : Proceeds from the transaction are expected to provide Gemini with the capital needed to further develop its clinical programs and preclinical portfolio, including GEM103, Further clinical programs in selected wet AMD populations, Future programs to treat...
Brand Name : GEM103
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 15, 2020
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Highest Development Status : Phase I
Sponsor : FS Development Corp
Deal Size : $216.0 million
Deal Type : Merger
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The company looking forward to topline data from this study and the potential to initiate a Phase 2 study supported by the CLARITY natural history study data.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 09, 2020
Lead Product(s) : GEM103
Therapeutic Area : Ophthalmology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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