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    [{"orgOrder":0,"company":"Genenta Science","sponsor":"ENEA Tech and Biomedical","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ITALY","productType":"Cell and Gene therapy","year":"2025","type":"Financing","leadProduct":"Pembrolizumab","moa":"||IL-alpha 2","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Genenta Science","amount2":0.02,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"Intravenous Infusion","sponsorNew":"Genenta Science \/ ENEA Tech and Biomedical","highestDevelopmentStatusID":"7","companyTruncated":"Genenta Science \/ ENEA Tech and Biomedical"},{"orgOrder":0,"company":"Genenta Science","sponsor":"Ospedale San Raffaele","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"ITALY","productType":"Undisclosed","year":"2023","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"IND Enabling","graph3":"Genenta 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    Find Clinical Drug Pipeline Developments & Deals by Genenta Science

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                            01

                            Genenta Science

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                            BioTrinity 2025
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                            Genenta Science

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                            Lead Product(s) : Temferon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : ENEA Tech and Biomedical

                            Deal Size : $21.9 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Genenta Secures €20M to Expand Pipeline Amid Brain Tumor Trial Success

                            Details : The financing will be used to advance their pipeline product Temferon, which is being evaluated for the treatment of methastatic Renal Cell Cancer.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            March 19, 2025

                            Lead Product(s) : Temferon,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : ENEA Tech and Biomedical

                            Deal Size : $21.9 million

                            Deal Type : Financing

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                            02

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Genenta Reprograms Tumor Microenvironment in GBM Patients

                            Details : Temferon uses ex-vivo gene transfer into autologous Tie2+ HSPCs to deliver immunomodulatory molecules via tumor-infiltrating monocytes; it's in phase 1/2 trials for uMGMT glioblastoma.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            August 02, 2024

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Genenta Secures Approval for Innovative Trial for Metastatic Renal Cell Cancer

                            Details : Temferon is based on ex-vivo gene transfer into autologous Tie2+ HSPCs to deliver immunomodulatory molecules. It is being evaluated for metastatic renal cell cancer.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 10, 2024

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Genenta Announces Ongoing Clinical Trial Progress and Proposed Expansion in Solid Tumor Treatments

                            Details : Temferon is a lenti-virus based hematopoietic stem progenitor cell immuno therapy enabling controlled and targeted interferon-α expression within cancers, which is investigated for the treatment of Glioblastoma Multiforme.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            July 28, 2023

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            The European Commission Grants Orphan Drug Designation to Temferon for Treatment of Glioma

                            Details : Temferon is a lenti-virus based hematopoietic stem progenitor cell immuno therapy enabling controlled and targeted interferon-α expression within cancers, which is investigated for the treatment of glioma.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 29, 2023

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Genenta Science

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Ospedale San Raffaele

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Genenta Announces Extension of License Agreement with Ospedale San Raffaele to All Solid Tumor Indications

                            Details : The amended and restated license agreement reinforces Genenta's long-term strategic relationship with OSR, who contributes unique and valuable expertise to the development of cell-based therapies. Genenta has exclusive worldwide commercial rights to Temf...

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            March 04, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Ospedale San Raffaele

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Grants Orphan Drug Designation to Temferon for Treatment of Glioblastoma Multiforme

                            Details : Temferon is a lenti-virus based hematopoietic stem progenitor cell immuno therapy enabling controlled and targeted interferon-alpha expression within cancers. Temferon modifies TEMs to release IFN-α inside tumors, rebuilding the immune system and counte...

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 03, 2023

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Genenta Data Presentation at AACR to Describe On-Target Biological Activity of Temferon™ in Unmethylated Gli...

                            Details : Data from 15 treated patients to be presented are expected to provide initial evidence of successful engraftment of Temferon-derived cells and of on-target biological activity in patients with uMGMT-GBM.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            September 03, 2022

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Genenta to Host Expert Fireside Chat on Immuno Gene & Cell Therapy for Treatment of Solid Tumors

                            Details : Temferon, a lenti-virus based hematopoietic stem progenitor cell immuno-gene therapy enabling controlled and targeted interferon-α expression within cancers. Biologically delivered via engineered tumor-infiltrating monocytes, generates immune responses...

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 20, 2022

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Genenta Science

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                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Genenta Progresses to Higher Dosing Cohort in Temferon Phase 1/2a Clinical Trial in Glioblastoma Multiforme

                            Details : Ongoing trial of Temferon™ in glioblastoma multiforme patients who have an unmethylated MGMT gene promoter has escalated to next planned dose, on basis of no drug-limiting toxicities observed at lower doses, in previous three dose level cohorts.

                            Product Name : Temferon

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 05, 2022

                            Lead Product(s) : Temferon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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