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Inc","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"DENMARK","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Tisotumab Vedotin","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Genmab","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Genmab \/ Pfizer Inc","highestDevelopmentStatusID":"12","companyTruncated":"Genmab \/ Pfizer Inc"},{"orgOrder":0,"company":"Genmab","sponsor":"ProfoundBio","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Large molecule","year":"2024","type":"Acquisition","leadProduct":"Rinatabart Sesutecan","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Genmab","amount2":1.8,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":1.8,"dosageForm":"Infusion","sponsorNew":"Genmab \/ Genmab","highestDevelopmentStatusID":"7","companyTruncated":"Genmab \/ Genmab"},{"orgOrder":0,"company":"Genmab","sponsor":"Pfizer Inc","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Tisotumab Vedotin","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"Genmab","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Genmab \/ Genmab","highestDevelopmentStatusID":"12","companyTruncated":"Genmab \/ Genmab"},{"orgOrder":0,"company":"Genmab","sponsor":"ProfoundBio","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Large molecule","year":"2024","type":"Acquisition","leadProduct":"Rinatabart Sesutecan","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Genmab","amount2":1.8,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Genmab

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Tepkinly (epcoritamab) is an IgG1-bispecific antibody, which is approved for the treatment of relapsed/refractory follicular lymphoma. It is designed to direct cytotoxic T cells selectively.

                          Brand Name : Tepkinly

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 19, 2024

                          Lead Product(s) : Epcoritamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : AbbVie Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Through the termination, responsibility for the continued development and potential commercialization of GEN1046 (acasunlimab), which is being evaluated for PD-L1-positive non small cell lung cancer.

                          Brand Name : GEN1046

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 05, 2024

                          Lead Product(s) : Acasunlimab,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : BioNTech

                          Deal Size : Undisclosed

                          Deal Type : Termination

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : GEN1046/BNT311 (acasunlimab), an investigational bispecific antibody (PD-L1x4-1BB), as monotherapy and in combination with pembrolizumab in patients with PDL(1)-positive mNSCLC.

                          Brand Name : GEN1046

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 05, 2024

                          Lead Product(s) : Acasunlimab,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : BioNTech

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Tepkinly (epcoritamab) is an IgG1-bispecific antibody, which is approved for the treatment of relapsed/refractory follicular lymphoma. It is designed to direct cytotoxic T cells selectively.

                          Brand Name : Tepkinly

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 28, 2024

                          Lead Product(s) : Epcoritamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : AbbVie Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Epkinly (epcoritamab) is an IgG1-bispecific antibody, which is approved for the treatment of relapsed/refractory follicular lymphoma. It is designed to direct cytotoxic T cells selectively.

                          Brand Name : Epkinly

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 26, 2024

                          Lead Product(s) : Epcoritamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : AbbVie Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Epkinly (epcoritamab) is an IgG1-bispecific antibody, which is approved for the treatment of relapsed/refractory follicular lymphoma. It is designed to direct cytotoxic T cells selectively.

                          Brand Name : Epkinly

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 02, 2024

                          Lead Product(s) : Epcoritamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : AbbVie Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : GEN1046/BNT311 (acasunlimab), an investigational bispecific antibody (PD-L1x4-1BB), as monotherapy and in combination with pembrolizumab in patients with PDL(1)-positive mNSCLC.

                          Brand Name : GEN1046

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 01, 2024

                          Lead Product(s) : Acasunlimab,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : BioNTech

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The acquisition grants Genmab worldwide rights to three clinical candidates, including Rina-S (rinatabart sesutecan), an FRα-targeted ADC aimed at treating ovarian and endometrial cancer.

                          Brand Name : Rina-S

                          Molecule Type : Large molecule

                          Upfront Cash : $1,800.0 million

                          May 21, 2024

                          Lead Product(s) : Rinatabart Sesutecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : ProfoundBio

                          Deal Size : $1,800.0 million

                          Deal Type : Acquisition

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Tivdak (tisotumab vedotin) is an antibody-drug conjugate that acts as coagulation factor III binding agent & tubulin inhibitor. It is approved for recurrent or metastatic cervical cancer.

                          Brand Name : Tivdak

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 29, 2024

                          Lead Product(s) : Tisotumab Vedotin

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Pfizer Inc

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Genmab acquires worldwide rights to PRO1184 (rinatabart sesutecan) for treating FRα-expressing platinum-resistant ovarian cancer and two other clinical candidates.

                          Brand Name : PRO1184

                          Molecule Type : Large molecule

                          Upfront Cash : $1,800.0 million

                          April 03, 2024

                          Lead Product(s) : Rinatabart Sesutecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : ProfoundBio

                          Deal Size : $1,800.0 million

                          Deal Type : Acquisition

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