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Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Approved FDF","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Geron \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Geron \/ Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Approved 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Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Approved FDF","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Geron \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Geron \/ Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Approved 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Capital","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Financing","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Phase III","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Geron \/ Hercules Capital","highestDevelopmentStatusID":"10","companyTruncated":"Geron \/ Hercules Capital"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Phase III","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous 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Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Phase III","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Geron \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Geron \/ Inapplicable"},{"orgOrder":0,"company":"Geron","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"Imetelstat","moa":"Telomerase reverse transcriptase","graph1":"Oncology","graph2":"Phase III","graph3":"Geron","amount2":0,"highestDevelopmentShortName":"Ph 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Find Clinical Drug Pipeline Developments & Deals by Geron

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                          Top Deals by Deal Size (USD bn)

                          01

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Rytelo (imetelstat) is an investigational, novel telomerase inhibitor, administered via intravenous infusion, indicated for transfusion-dependent anemia due to lower-risk MDS.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          December 13, 2024

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : The proceeds will support the commercial launch of Rytelo (imetelstat), a first-in-class treatment that works by inhibiting telomerase enzymatic activity, in the U.S. and potential launch in the EU.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : $250.0 million

                          November 07, 2024

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Royalty Pharma

                          Deal Size : $250.0 million

                          Deal Type : Financing

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                          03

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Onco360 partner by Geron for the distribution of Rytelo (imetelstat)l, telomerase inhibitor, approved for the treatment of adult patients with low to intermediate-risk myelodysplastic syndromes.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          July 12, 2024

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Recipient : Onco360

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          04

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Rytelo (imetelstat) is an investigational, novel telomerase inhibitor, administered via intravenous infusion, being developed for relapsed/refractory myelofibrosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          June 06, 2024

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Geron plans to fund commercialization of GRN163L and potential launch of imetelstat for low/intermediate-1 risk myelodysplastic syndromes in the U.S. and EU.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          March 19, 2024

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : TD Cowen

                          Deal Size : $150.0 million

                          Deal Type : Public Offering

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                          06

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : GRN163L (imetelstat) is an investigational, novel telomerase inhibitor, administered via intravenous infusion, being developed for relapsed/refractory myelofibrosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          December 06, 2023

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : GRN163L (imetelstat) is an investigational, novel telomerase inhibitor, by which drug inhibits the uncontrolled proliferation of malignant stem and progenitor cells in relapsed/refractory AML or higher risk MDS resulting in malignant cell apoptosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          September 29, 2023

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : GRN163L (imetelstat) is an investigational, novel telomerase inhibitor, by which drug inhibits the uncontrolled proliferation of malignant stem and progenitor cells in Relapsed/Refractory AML or Higher Risk MDS resulting in malignant cell apoptosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          August 22, 2023

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : GRN163L (imetelstat) is an investigational, novel telomerase inhibitor, by which drug inhibits the uncontrolled proliferation of malignant stem and progenitor cells in relapsed/refractory AML or higher risk MDS resulting in malignant cell apoptosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          August 21, 2023

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : GRN163L (imetelstat) is an investigational, novel telomerase inhibitor, by which drug inhibits the uncontrolled proliferation of malignant stem and progenitor cells in Relapsed/Refractory AML or Higher Risk MDS resulting in malignant cell apoptosis.

                          Product Name : Rytelo

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          June 29, 2023

                          Lead Product(s) : Imetelstat

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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