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\/ BofA Securities","highestDevelopmentStatusID":"8","companyTruncated":"Kura Oncology \/ BofA Securities"},{"orgOrder":0,"company":"Kura Oncology","sponsor":"BofA Securities","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2023","type":"Public Offering","leadProduct":"Ziftomenib","moa":"","graph1":"Oncology","graph2":"Phase II","graph3":"Kura Oncology","amount2":0.10000000000000001,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0.10000000000000001,"dosageForm":"Capsule","sponsorNew":"Kura Oncology \/ BofA Securities","highestDevelopmentStatusID":"8","companyTruncated":"Kura Oncology \/ BofA Securities"},{"orgOrder":0,"company":"Oryzon Genomics","sponsor":"European Commission","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SPAIN","productType":"Small molecule","year":"2022","type":"Funding","leadProduct":"Iadademstat","moa":"","graph1":"Oncology","graph2":"IND 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Find Clinical Drug Pipeline Developments & Deals for Gilteritinib Fumarate

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01

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : KO-539 (ziftomenib) is a potent and selective a menin-MLL(KMT2A) inhibitor, which is being evaluated in phase 1 clinical trials in patients with NPM1-mutant & KMT2A-rearranged acute myeloid leukemia.

Product Name : KO-539

Product Type : Small molecule

Upfront Cash : Not Applicable

February 26, 2024

Lead Product(s) : Ziftomenib,Gilteritinib Fumarate,Fludarabine Phosphate

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : AstraZeneca

Deal Size : Not Applicable

Deal Type : Not Applicable

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02

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Xospata (gilteritinib) is a receptor tyrosine kinase inhibitor being evaluated in combination with venetoclax and azacitidine for relapsed/refractory AML with an FLT3 mutation.

Product Name : Xospata

Product Type : Small molecule

Upfront Cash : Not Applicable

January 30, 2024

Lead Product(s) : Gilteritinib Fumarate,Venetoclax,Azacitidine

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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03

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : The net proceeds will be used for the development of KO-539 (ziftomenib), a potent and selective inhibitor, being developed in combination with Xospata (gilteritinib), an inhibitor of FLT3, for the treatment of NPM1-mutated acute myeloid leukemia.

Product Name : KO-539

Product Type : Small molecule

Upfront Cash : Undisclosed

June 14, 2023

Lead Product(s) : Ziftomenib,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : IND Enabling

Sponsor : BofA Securities

Deal Size : $100.0 million

Deal Type : Public Offering

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04

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : The net proceeds will be used for the development of KO-539 (ziftomenib), a potent and selective inhibitor, being developed in combination with Xospata (gilteritinib), an inhibitor of FLT3, for the treatment of NPM1-mutated acute myeloid leukemia.

Product Name : KO-539

Product Type : Small molecule

Upfront Cash : Undisclosed

June 13, 2023

Lead Product(s) : Ziftomenib,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : IND Enabling

Sponsor : BofA Securities

Deal Size : $100.0 million

Deal Type : Public Offering

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05

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1 with powerful differentiating effect in hematologic cancer. It is being investigated in with gilteritinib for relapsed/refractory AML harboring a FMS-like tyrosine kinas...

Product Name : ORY-1001

Product Type : Small molecule

Upfront Cash : Not Applicable

March 15, 2023

Lead Product(s) : Iadademstat,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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06

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Xospata (gilteritinib) is a FLT3 inhibitor with demonstrated activity against FLT3-ITD, a common driver mutation that presents with a high disease burden and poor prognosis, and FLT3-tyrosine kinase domain mutations.

Product Name : Xospata

Product Type : Small molecule

Upfront Cash : Not Applicable

March 09, 2023

Lead Product(s) : Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : Approved

Sponsor : Blood and Marrow Transplant Clinical Trials Network

Deal Size : Not Applicable

Deal Type : Not Applicable

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07

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Lanraplenib (Lanra) has demonstrated favorable pharmacokinetic (PK), pharmacodynamic (PD) and safety in more than 250 trial participants, including healthy volunteers and patients with autoimmune diseases.

Product Name : Lanra

Product Type : Small molecule

Upfront Cash : Not Applicable

November 08, 2022

Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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08

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Lanra (lanraplenib) is the company’s next-generation spleen tyrosine kinase (SYK) inhibitor. In addition to lanraplenib, Kronos Bio is also evaluating its lead investigational SYK inhibitor, entospletinib, in the Phase 3 patients with NPM1-mutated AML.

Product Name : Lanra

Product Type : Small molecule

Upfront Cash : Not Applicable

August 22, 2022

Lead Product(s) : Lanraplenib,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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09

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : The net proceeds will be used to evaluate efficacy and optimal dose of ORY-1001 (iadademstat), a novel, highly potent, and selective inhibitor of LSD1, plus Xospata (gilteritinib), an inhibitor of FLT3, in patients with relapsed/refractory AML with FLT3 ...

Product Name : ORY-1001

Product Type : Small molecule

Upfront Cash : Undisclosed

June 07, 2022

Lead Product(s) : Iadademstat,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : IND Enabling

Sponsor : European Commission

Deal Size : $2.0 million

Deal Type : Funding

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10

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : ERAS-007 is a highly potent and selective small molecule ERK1/2 inhibitor. It is being evaluated in phase 1/2 clinical trials in combination with gilteritinib for the treatment of acute myeloid leukemia.

Product Name : ERAS-007

Product Type : Small molecule

Upfront Cash : Not Applicable

April 12, 2022

Lead Product(s) : ERAS-007,Gilteritinib Fumarate

Therapeutic Area : Oncology

Highest Development Status : Phase I/ Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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