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therapy","year":"2024","type":"Acquisition","leadProduct":"CMG1A46","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"GSK","amount2":0.84999999999999998,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"GSK \/ GSK","highestDevelopmentStatusID":"14","companyTruncated":"GSK \/ GSK"},{"orgOrder":0,"company":"ViiV Healthcare","sponsor":"Fundaci\u00f3n Hu\u00e9sped","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Dolutegravir Sodium","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"ViiV Healthcare","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"ViiV Healthcare \/ Fundaci\u00f3n Hu\u00e9sped","highestDevelopmentStatusID":"14","companyTruncated":"ViiV Healthcare \/ Fundaci\u00f3n Hu\u00e9sped"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : GSK3511294 (depemokimab) is the first ultra-long-acting biologic with a binding affinity for IL-5. It is being evaluated for the treatment of chronic rhinosinusitis with nasal polyps.

                          Brand Name : GSK3511294

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 14, 2024

                          Lead Product(s) : Depemokimab

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : MHLW has approved Nucala (mepolizumab), a monoclonal antibody that targets IL-5, for the treatment of chronic rhinosinusitis with nasal polyps in adult patients.

                          Brand Name : Nucala

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 29, 2024

                          Lead Product(s) : Mepolizumab

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The Flagship collaborates with GSK to discover and develop a portfolio of future transformational medicines and vaccines for the treatment of respiratory and immunology diseases.

                          Brand Name : Undisclosed

                          Molecule Type : Vaccine

                          Upfront Cash : $150.0 million

                          July 29, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Discovery

                          Recipient : Flagship Pioneering

                          Deal Size : $7,200.0 million

                          Deal Type : Collaboration

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                          04

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Under the agreement, GSK has the rights to develop GSK5458448/SCY-078 (ibrexafungerp), a novel oral glucan synthase inhibitor and commercialize Brexafemme in all countries except the greater China.

                          Brand Name : Brexafemme

                          Molecule Type : Small molecule

                          Upfront Cash : $90.0 million

                          July 23, 2024

                          Lead Product(s) : Ibrexafungerp Citrate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Recipient : Scynexis

                          Deal Size : $593.0 million

                          Deal Type : Licensing Agreement

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                          05

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : The collaboration aims to advance the clinical development of late-stage product EOS-448 (belrestotug) in combination with Dostarlimab for the treatment of PD-L1 high Non-small Cell Lung Cancer.

                          Brand Name : EOS-448

                          Molecule Type : Large molecule

                          Upfront Cash : $625.0 million

                          July 08, 2024

                          Lead Product(s) : Belrestotug,Dostarlimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Recipient : Iteos Therapeutics

                          Deal Size : $2,075.0 million

                          Deal Type : Collaboration

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                          06

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Through the acquisition, Reddy will leverage the NRT portfolio, which includes Nicotinell (nicotine) in various formats such as lozenges, patches, and gum, across all applicable global market.

                          Brand Name : Nicotinell

                          Molecule Type : Small molecule

                          Upfront Cash : $579.8 million

                          June 26, 2024

                          Lead Product(s) : Nicotine

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Discovery

                          Sponsor : Dr. Reddy\'s Laboratories

                          Deal Size : $632.9 million

                          Deal Type : Acquisition

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                          07

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Omjjara (momelotinib) is a once-a-day, oral JAK1/JAK2 and activin A receptor type 1 (ACVR1) inhibitor. It is indicated for the treatment of myelofibrosis.

                          Brand Name : Omjjara

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 25, 2024

                          Lead Product(s) : Momelotinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Arexvy (respiratory syncytial virus vaccine, adjuvanted) is a vaccine drug candidate, which is approved for the treatment of respiratory syncytial virus disease in adults aged 50-59.

                          Brand Name : Arexvy

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          June 07, 2024

                          Lead Product(s) : Respiratory Syncytial Virus Vaccine, Adjuvanted

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Through acquisition, GSK to integrate Elsie’s oligonucleotide discovery, synthesis, and delivery technologies to enhance GSK’s broad oligonucleotide pipeline for difficult-to-treat diseases.

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 06, 2024

                          Lead Product(s) : Oligonucleotide-based Therapy

                          Therapeutic Area : Technology

                          Highest Development Status : Discovery Platform

                          Recipient : Elsie Biotechnologies

                          Deal Size : $50.0 million

                          Deal Type : Acquisition

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                          10

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Flu mRNA (GSK4382276A) is a intramuscularly administered mRNA-based multivalent seasonal influenza vaccine, which is being evaluated for the treatment of seasonal influenza.

                          Brand Name : Flu mRNA

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          May 28, 2024

                          Lead Product(s) : GSK4382276A

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : CureVac

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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