Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
GT Biopharma Receives FDA IND Clearance for GTB-3650 NK Cell Engager in CD33+ Leukemia
Details : GTB-3650, a tri-specific molecule that binds to CD16 receptor utilizes company's proprietary TriKE platform, has recieved FDA clearance of IND application for CD33+ r/r AML and r/r high risk MDS.
Brand Name : GTB-3650
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 27, 2024
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
GT Biopharma Announces IND Submission for GTB-3650 for Treatment of CD33+ Leukemia
Details : GTB-3650 is a 2nd generation nanobody TriKE®, that binds the CD16 receptor on NK cells. It's IND application is submitted after the preclinical studies for the treatment of CD33+ leukemia, including r/r acute myelogenous leukemia & high-risk myelodyspla...
Brand Name : GTB-3650
Molecule Type : Large molecule
Upfront Cash : Not Applicable
December 04, 2023
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-3650,CAR NK Cell Therapy
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Fate Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Preclinical data to be presented demonstrate that iPSC-derived, MICA/B-targeted CAR NK cells induced potent activity against AML cell line HL60, and further enhancement of activity was achieved in combination with GTB-3650 through antibody-dependent cell...
Brand Name : GTB-3650
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 03, 2022
Lead Product(s) : GTB-3650,CAR NK Cell Therapy
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Fate Therapeutics
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-3550
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : GTB-3550 is a single-chain, tri-specific scFv recombinant fusion protein conjugate composed of the variable regions of the heavy and light chains of anti-CD16 and anti-CD33 antibodies and human IL-15.
Brand Name : GTB-3550
Molecule Type : Large molecule
Upfront Cash : Not Applicable
October 06, 2022
Lead Product(s) : GTB-3550
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : GTB-5550 TriKE is a tri-specific molecule composed of a dual camelid nanobody that binds the CD16 receptor on NK cells, the single chain variable fragment (scFv) of an anti-B7H3 antibody, and human IL-15.
Brand Name : GTB-5550
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 12, 2022
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Cytovance Biologics
Deal Size : Undisclosed
Deal Type : Agreement
GT Biopharma Affirms Manufacturing Timeline For Lead Investigational Asset GTB-3650
Details : GTB-3650 is the Company's lead second-generation Tri-Specific Killer Engager TriKE ® program currently in preclinical development for the treatment of relapsed/refractory acute myelogenous leukemia (AML) and high-risk myelodysplastic syndrome (MDS).
Brand Name : GTB-3650
Molecule Type : Large molecule
Upfront Cash : Undisclosed
August 30, 2022
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Cytovance Biologics
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : GTB-7550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : GTB-7550 (CAM-161519) is Company’s CD19-targeted TriKE targeted against B-cell lymphomas and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumors and he...
Brand Name : CAM-161519
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 10, 2022
Lead Product(s) : GTB-7550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : GTB-5550 is the Company’s B7H3-targeted tri-specific killer engager (TriKE) and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumor cancers.
Brand Name : GTB-5550
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 11, 2022
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : NK cell mediated killing increased statistically significantly across all multiple myeloma cell lines tested. Combination therapy with GTB-5550 and anti-cancer agent showed enhanced killing as compared to NK cells or TriKE alone.
Brand Name : GTB-5550
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 21, 2022
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tri-specific NK-cell Engager
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The pre-clinical evidence suggests, despite the difference in circulating immune cells of Stage IVB NSCLC patients, mesothelin-targeted Tri-specific Killer Engager can work alongside current standard of care and provide benefit even in the hypoxic enviro...
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 09, 2022
Lead Product(s) : Tri-specific NK-cell Engager
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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