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Capital"},{"orgOrder":0,"company":"HDT Biotech","sponsor":"Gennova Biopharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"INDIA","productType":"Vaccine","year":"2020","type":"Not Applicable","leadProduct":"HGCO19","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase I\/ Phase II","graph3":"HDT Biotech","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"HDT Biotech \/ HDT Biotech Corporation","highestDevelopmentStatusID":"7","companyTruncated":"HDT Biotech \/ HDT Biotech Corporation"},{"orgOrder":0,"company":"HDT Biotech","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Not Applicable","leadProduct":"HDT-301","moa":"SARS-CoV-2 spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase II\/ Phase III","graph3":"HDT Biotech","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"HDT Biotech \/ Not Applicable","highestDevelopmentStatusID":"9","companyTruncated":"HDT Biotech \/ Not Applicable"},{"orgOrder":0,"company":"HDT Biotech","sponsor":"Gennova Biopharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2021","type":"Not Applicable","leadProduct":"HDT-301","moa":"SARS-CoV-2 spike protein","graph1":"Infections and Infectious Diseases","graph2":"Phase II\/ Phase III","graph3":"HDT Biotech","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"HDT Biotech \/ Gennova Biopharmaceuticals","highestDevelopmentStatusID":"9","companyTruncated":"HDT Biotech \/ Gennova 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Find Clinical Drug Pipeline Developments & Deals by HDT Biotech

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                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The partnership aims to support HDT in advancing its next-generation vaccine HDT-521. Which is being evaluated in the preclinical trial studies for the treatment of prostate cancer.

                          Brand Name : HDT-521

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          January 23, 2024

                          Lead Product(s) : HDT-521

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : BARDA

                          Deal Size : $0.7 million

                          Deal Type : Partnership

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The vaccine uses self-amplifying RNA (or “saRNA”), which replicates itself following administration and is thus effective at extremely low doses. In addition, it is stable at refrigerator temperatures—unlike current mRNA vaccines.

                          Brand Name : HDT-301

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          June 29, 2022

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : HDT301, an HDT Bio’s technology uses self-replicating RNA and has the potential to deliver a COVID-19 vaccine targeting multiple variants, providing broad protection from disease and reduced transmission from breakthrough infections.

                          Brand Name : HDT-301

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          April 05, 2022

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Company RNA-based vaccine, HDT-301 (HGCO19) offers simpler manufacturing, greater stability, and vastly lower effective dosing than current mRNA COVID-19 vaccines.

                          Brand Name : HDT-301

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          December 13, 2021

                          Lead Product(s) : HGCO19

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I

                          Sponsor : Quratis Co., Ltd

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Gennova Biopharmaceuticals, successfully completed a Phase 1 trial of its COVID-19 RNA vaccine candidate HGCO19 and Indian regulatory authorities have approved the start of pivotal Phase 2/3 trials.

                          Brand Name : HGCO19

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          August 31, 2021

                          Lead Product(s) : HGCO19

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Gennova Biopharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : This agreement will enable Quratis to manufacture HDT Bio's next-generation COVID-19 vaccine, HGCO19 and distribute it across much of East Asia.

                          Brand Name : HGCO19

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          August 16, 2021

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Quratis Co., Ltd

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : HDT Bio has also developed HGCO19, a LION-based COVID-19 vaccine, in collaboration with Gennova Biopharmaceuticals of Pune, which is currently is being tested in India in a Phase 1/2 clinical trial.

                          Brand Name : HGCO19

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          July 01, 2021

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Gennova Biopharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : HGCO19, is a novel mRNA vaccine candidate containing a short, synthetic version encoding the spike protein (antigen) of the novel coronavirus, SARS-CoV-2, reported to interact with receptors on host cells.

                          Brand Name : HGCO19

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          May 04, 2021

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The Drugs Controller General of India (DCGI) has granted conditional permission for phases 1 and 2 human clinical trial of the COVID-19 vaccine candidate, HGCO19, developed by the Pune-based Gennova Biopharmaceuticals Ltd in collaboration with HDT, USA.

                          Brand Name : HGCO19

                          Molecule Type : Vaccine

                          Upfront Cash : Not Applicable

                          December 09, 2020

                          Lead Product(s) : HGCO19

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : Gennova Biopharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Proceeds will be used largely to support continued development of the company’s COVID-19 vaccine candidate, HDT-301. The vaccine is slated to enter clinical trials in Q4 2020 in partnership with the NIH/NIAID.

                          Brand Name : HDT-301

                          Molecule Type : Vaccine

                          Upfront Cash : Undisclosed

                          October 05, 2020

                          Lead Product(s) : HDT-301

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Zoic Capital

                          Deal Size : $3.0 million

                          Deal Type : Financing

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