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England","pharmaFlowCategory":"D","therapeuticArea":"Hematology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Agreement","leadProduct":"Exagamglogene Autotemcel","moa":"BCL11A gene expression","graph1":"Hematology","graph2":"Approved FDF","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Hematology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Vertex Pharmaceuticals \/ NHS England","highestDevelopmentStatusID":"15","companyTruncated":"Vertex Pharmaceuticals \/ NHS England"},{"orgOrder":0,"company":"Bristol Myers Squibb","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hematology","country":"U.S.A","productType":"HPAPI","year":"2021","type":"Inapplicable","leadProduct":"Apixaban","moa":"Factor Xa","graph1":"Hematology","graph2":"Approved FDF","graph3":"Bristol Myers 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Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : The agreement aims for eligible sickle cell disease (SCD) patients to access the CRISPR/Cas9 gene-edited therapy, Casgevy (exagamglogene autotemcel).

                          Product Name : Casgevy

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 30, 2025

                          Lead Product(s) : Exagamglogene Autotemcel

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : NHS England

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          02

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Apixaban is an oral, reversible, and selective active site inhibitor of FXa. Apixaban inhibits free and clot-bound FXa, and prothrombinase activity. By inhibiting FXa, apixaban decreases thrombin generation and thrombus development.

                          Product Name : Apixaban-Generic

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          February 28, 2023

                          Lead Product(s) : Apixaban

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : AMVUTTRA (vutrisiran sodium) is an RNAi therapeutic, which target and silence specific mRNA, blocking the production of wild-type and variant transthyretin protein before it is made. In the HELIOS-A study, AMVUTTRA met all endpoints of the study at both ...

                          Product Name : Amvuttra

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          September 20, 2022

                          Lead Product(s) : Vutrisiran Sodium

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Amvuttra (vutrisiran sodium), is an RNAi therapeutic approved in the United States for the treatment of the polyneuropathy of hATTR amyloidosis in adults. Vutrisiran is also in development for the treatment of ATTR amyloidosis.

                          Product Name : Amvuttra

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          July 22, 2022

                          Lead Product(s) : Vutrisiran Sodium

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : FDA approval is based on positive 9-month results from HELIOS-A Phase 3 study, where AMVUTTRA (Vutrisiran) significantly improved signs and symptoms of polyneuropathy, with more than 50 percent of patients experiencing halting or reversal of their diseas...

                          Product Name : Amvuttra

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          June 13, 2022

                          Lead Product(s) : Vutrisiran Sodium

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : It alleged that Micro Labs has already listed the apixaban product in 2.5 mg and 3 mg tablet strengths under the probable brand name Apivas on various third party websites and has also applied for registration of the trade mark Apivas before the Indian T...

                          Product Name : Eliquis

                          Product Type : HPAPI

                          Upfront Cash : Inapplicable

                          August 19, 2021

                          Lead Product(s) : Apixaban

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          ASPEN
                          Not Confirmed
                          ASPEN
                          Not Confirmed

                          Details : Partnership with Gen enables Alnylam to extend access to ONPATTRO to patients suffering from hereditary ATTR amyloidosis with polyneuropathy in Turkey.

                          Product Name : Onpattro

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          March 25, 2020

                          Lead Product(s) : Patisiran

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved FDF

                          Sponsor : Alnylam Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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