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(Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"CohBar","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"CohBar \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"CohBar \/ Inapplicable"},{"orgOrder":0,"company":"Metacrine","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"MET409","moa":"FX receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Metacrine","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Metacrine \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Metacrine \/ Inapplicable"},{"orgOrder":0,"company":"Sirnaomics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"STP707","moa":"TGF-beta 1\/COX-2","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Sirnaomics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Sirnaomics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Sirnaomics \/ Inapplicable"},{"orgOrder":0,"company":"Kynos Therapeutics","sponsor":"Dr. Falk Pharma","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2024","type":"Acquisition","leadProduct":"KNS366","moa":"KMO","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Kynos Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Kynos Therapeutics \/ Dr. Falk Pharma","highestDevelopmentStatusID":"6","companyTruncated":"Kynos Therapeutics \/ Dr. Falk Pharma"},{"orgOrder":0,"company":"Kynos Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"KNS366","moa":"KMO","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Kynos Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Kynos Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Kynos Therapeutics \/ Inapplicable"}]

Find Drugs for Hepatology (Liver, Pancreatic, Gall Bladder) in Phase I Clinical Development

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAN
                          Not Confirmed
                          AAN
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                          Details : CF102 (namodenoson) is a small orally bioavailable drug that binds to the A3AR. It is being evaluated for the treatment of Decompensated Liver Cirrhosis.

                          Product Name : CF102

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 18, 2025

                          Lead Product(s) : Namodenoson

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : Under the licensing agreement,Lilly will focus on the development and commercialization of OliX’s OLX75016, a Phase 1 candidate primarily targeting metabolic-associated steatohepatitis indications.

                          Product Name : OLX75016

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          February 10, 2025

                          Lead Product(s) : OLX75016

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Eli Lilly

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : Through the acquisition, Dr. Falk Pharma will add KNS366 to its R&D pipeline and further explore its potential in upcoming clinical trials for the treatment of acute pancreatitis.

                          Product Name : KNS366

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : KNS366

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Dr. Falk Pharma

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          04

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : RTY-694 is a potent, orally active ABCB4/BSEP positive functional modulator (PFM) that improves bile composition and enhances bile flow, being developed for primary sclerosing cholangitis (PSC).

                          Product Name : RTY-694

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 22, 2024

                          Lead Product(s) : RTY-694

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : The funding is intended to support the clinical advancement of an early-stage trial of HRX-215 for the treatment of patients undergoing liver regeneration.

                          Product Name : HRX-215

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          October 07, 2024

                          Lead Product(s) : HRX-215

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Vesalius Biocapital IV

                          Deal Size : $16.2 million

                          Deal Type : Series C Financing

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                          06

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : ALG-055009 appears to be a best-in-class thyroid hormone receptor beta (THR-ß) agonist discovered by Aligos for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).

                          Product Name : ALG-055009

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 21, 2024

                          Lead Product(s) : ALG-055009

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : KNS366, a first-in-class small molecule KMO inhibitor, is being investigated for treating acute and chronic inflammatory disorders like pancreatitis and kidney injury.

                          Product Name : KNS366

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 22, 2024

                          Lead Product(s) : KNS366

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : SZN-043 is a hepatocyte-targeted R-spondin mimetic, monoclonal antibody. It is being evaluated for the treatment of alcohol-associated hepatitis.

                          Product Name : SZN-043

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 06, 2024

                          Lead Product(s) : SZN-043

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          09

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : TVB-264 (denifanstat) is a selective FASN inhibitor, which is under clinical development for the treatment of metabolic dysfunction-associated steatohepatitis/Non-alcoholic Steatohepatitis.

                          Product Name : TVB-2640

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 27, 2024

                          Lead Product(s) : Denifanstat

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AAN
                          Not Confirmed
                          AAN
                          Not Confirmed

                          Details : HRX-0215, a small molecule MKK4 inhibitor, is being evaluated for treating hepatic steatosis, liver damage, and NASH-associated liver cancer.

                          Product Name : HRX-215

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 14, 2024

                          Lead Product(s) : HRX-215

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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