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Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Ashvattha Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"twoXAR Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"TXR-611","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"twoXAR Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"twoXAR Pharmaceutical \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"twoXAR Pharmaceutical \/ Inapplicable"},{"orgOrder":0,"company":"OliX Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"SOUTH KOREA","productType":"Cell and Gene therapy","year":"2021","type":"Inapplicable","leadProduct":"OLX702A","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"OliX Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"OliX Pharmaceutical \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"OliX Pharmaceutical \/ Inapplicable"},{"orgOrder":0,"company":"OliX Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"SOUTH KOREA","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"OLX702A","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"OliX 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Sciences"},{"orgOrder":0,"company":"Dicerna Pharmaceuticals","sponsor":"Boehringer Ingelheim GmbH","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Collaboration","leadProduct":"DCR-LIV2","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"Dicerna Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Dicerna Pharmaceuticals \/ Boehringer Ingelheim GmbH","highestDevelopmentStatusID":"4","companyTruncated":"Dicerna Pharmaceuticals \/ Boehringer Ingelheim GmbH"},{"orgOrder":0,"company":"Acquist Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small 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Bladder)","graph2":"Preclinical","graph3":"EpiPharm","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"EpiPharm \/ CalciMedica","highestDevelopmentStatusID":"4","companyTruncated":"EpiPharm \/ CalciMedica"},{"orgOrder":0,"company":"Corvidia Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Peptide","year":"2020","type":"Inapplicable","leadProduct":"D6PV","moa":"APOC-3","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"Corvidia Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Corvidia Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Corvidia Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Lamassu Pharma","sponsor":"National Institutes of Health","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Funding","leadProduct":"RABI-767","moa":"Lipase","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Preclinical","graph3":"Lamassu Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lamassu Pharma \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"Lamassu Pharma \/ National Institutes of Health"},{"orgOrder":0,"company":"CalciMedica","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Other Small 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Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Study Phase : Preclinical

                          Sponsor : Rona Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Details : Rona licensed Sanofi’s siRNA platform to enable discovery programs in expanded therapeutic areas including neuro and muscular diseases, for which Sanofi has an exclusive option to acquire neuro and muscular disease candidates for ex-China territories.

                          Product Name : Undisclosed

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          July 25, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Rona Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

                          Sanofi Company Banner

                          02

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Thykamine is an innovative botanical pharmaceutical product, which is currently being evaluated for the treatment of metabolic dysfunction-associated steatohepatitis (MASH).

                          Product Name : PUR0110

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          February 13, 2025

                          Lead Product(s) : Thykamine

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The net proceeds from the offering will primarily be used to fund the advancement of current or future product candidates, including AX-0810 for the treatment of primary sclerosing cholangitis.

                          Product Name : AX-0810

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 25, 2024

                          Lead Product(s) : AX-0810

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Evercore ISI

                          Deal Size : $63.0 million

                          Deal Type : Public Offering

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                          04

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The net proceeds from the offering will primarily be used to fund the advancement of current or future product candidates, including AX-0810 for the treatment of primary sclerosing cholangitis.

                          Product Name : AX-0810

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 22, 2024

                          Lead Product(s) : AX-0810

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Evercore ISI

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          05

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The net proceeds from the offering will primarily be used to fund the advancement of current or future product candidates, including AX-0810 for the treatment of primary sclerosing cholangitis.

                          Product Name : AX-0810

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          October 22, 2024

                          Lead Product(s) : AX-0810

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Evercore ISI

                          Deal Size : $75.0 million

                          Deal Type : Public Offering

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                          06

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The collaboration aims to combine Editas’s CRISPR Cas12a genome editing systems with Genevant’s LNP technology in the development of in vivo gene editing medicines directed to two undisclosed targets.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          October 21, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Editas Medicine

                          Deal Size : $238.0 million

                          Deal Type : Collaboration

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                          07

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : insitro has an option to in-license GalNAc delivery technology from Lilly that it will combine with two different siRNA, each specifically directed toward a different target in the liver.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          October 10, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Insitro

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          08

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : AX-0810 is an editing oligonucleotide development program targeting SLC10A1 RNA, providing a controlled approach aimed at reducing bile acids concentration in the liver for cholestatic diseases.

                          Product Name : AX-0810

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          August 05, 2024

                          Lead Product(s) : AX-0810

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : PRO-140 (leronlimab) a monocloncal antibody works by blocking the activity of CCR5 receptor. It is currently in preclinical in combination with Resmetirom for the treatment of liver fibrosis.

                          Product Name : Vyrologix

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          June 27, 2024

                          Lead Product(s) : Leronlimab,Resmetirom

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : SMC Laboratories

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : GSK selected two programs utilizing Wave's GalNAc-siRNA format for hepatology, advancing to development candidates after target validation.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $12.0 million

                          April 23, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Preclinical

                          Sponsor : GSK

                          Deal Size : $3,312.0 million

                          Deal Type : Collaboration

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