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01

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Hepion and Pharma Two B have terminated their merger agreement. Pharma Two B will continue advancing P2B001 (Pramipexole + Rasagiline), a therapeutic designed to treat Parkinson's disease.

Product Name : Undisclosed

Product Type : Small molecule

Upfront Cash : Undisclosed

December 11, 2024

Lead Product(s) : Pramipexole Dihydrochloride,Rasagiline Mesylate

Therapeutic Area : Neurology

Highest Development Status : Phase III

Recipient : Pharma Two B

Deal Size : Undisclosed

Deal Type : Termination

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02

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Through the merger, the company will operate under Pharma Two B and also advance P2B001 (Pramipexole+Rasagiline), an easy-to-use therapeutic approach, that is designed to address PD.

Product Name : P2B001

Product Type : Small molecule

Upfront Cash : Undisclosed

July 22, 2024

Lead Product(s) : Pramipexole Dihydrochloride,Rasagiline Mesylate

Therapeutic Area : Neurology

Highest Development Status : Phase III

Recipient : Pharma Two B

Deal Size : Undisclosed

Deal Type : Merger

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03

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) is a cyclophilin A inhibitor currently undergoing mid-stage clinical trials with patients for the treatment of non-alcoholic steatohepatitis.

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 19, 2024

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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04

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) is a Cyclophilin A inhibitor has been shown to reduce liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of Idiopathic Pulmonary Fibrosis, and has demonstrated antiviral activities towards HBV, HCV, and ...

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 13, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Hepion intends to use the net proceeds from the offering for clinical development of CRV431 (rencofilstat), an oral drug candidate for nonalcoholic steatohepatitis (NASH) and viral hepatitis-induced liver disease.

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

September 29, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Alliance Global Partners

Deal Size : $5.0 million

Deal Type : Public Offering

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06

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) is a Cyclophilin A inhibitor has been shown to reduce liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of Idiopathic Pulmonary Fibrosis, and has demonstrated antiviral activities towards HBV, HCV, and ...

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

September 14, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Pulmonary/Respiratory Diseases

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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07

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) is a Cyclophilin A inhibitor has been shown to reduce liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of NASH, and has demonstrated antiviral activities towards HBV, HCV, and HDV.

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

June 15, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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08

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) is a Cyclophilin A inhibitor has been shown to reduce liver fibrosis and hepatocellular carcinoma tumor burden in experimental models of NASH, and has demonstrated antiviral activities towards HBV, HCV, and HDV.

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

May 22, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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09

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : Rencofilstat specifically binds cyclophilin isomerase enzymes and inhibits cyclophilin function. Rencofilstat is being examined as a potential therapeutic for multiple myeloma.

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 18, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Oncology

Highest Development Status : Preclinical

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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10

ICHH-25
Not Confirmed
ICHH-25
Not Confirmed

Details : CRV431 (rencofilstat) specifically binds cyclophilin isomerase enzymes and inhibits cyclophilin function, resulting in reduced inflammatory damage to the liver.. Rencofilstat has demonstrated efficacy in two distinct animal models of NASH and HBV replica...

Product Name : CRV431

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

January 10, 2023

Lead Product(s) : Rencofilstat

Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

Highest Development Status : Phase II

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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