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    [{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Salinomycin","moa":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Hillstream BioPharma \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Not Applicable"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"ThinkEquity","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2022","type":"Public Offering","leadProduct":"HSB-1216","moa":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream 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BioPharma"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"HSB-1216","moa":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Hillstream BioPharma \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"Hillstream BioPharma \/ Not Applicable"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"ThinkEquity","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2023","type":"Public Offering","leadProduct":"HSB-1216","moa":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"Hillstream 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Institute","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Licensing Agreement","leadProduct":"Antibody Drug Conjugate","moa":"","graph1":"Oncology","graph2":"Discovery","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Hillstream BioPharma \/ Hillstream BioPharma","highestDevelopmentStatusID":"2","companyTruncated":"Hillstream BioPharma \/ Hillstream BioPharma"},{"orgOrder":0,"company":"Hillstream BioPharma","sponsor":"Avior Bio","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Small molecule","year":"2023","type":"Agreement","leadProduct":"Nalmefene Hydrochloride","moa":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I\/ Phase II","graph3":"Hillstream BioPharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Film","sponsorNew":"Hillstream BioPharma \/ Hillstream BioPharma","highestDevelopmentStatusID":"7","companyTruncated":"Hillstream BioPharma \/ Hillstream BioPharma"}]

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                            01

                            Hillstream BioPharma

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                            Lead Product(s) : Nalmefene Hydrochloride

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I/ Phase II

                            Recipient : Avior Bio

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Hillstream Enters into an Exclusive Option Agreement to Acquire a Clinical Stage Asset for Chronic Pruritis

                            Details : Through the agreement, Hillstream aims to acquire a clinical stage asset, AV104 (nalmefene), an opioid antagonist, but first it intends to seek approval in an orphan disease for the treatment of moderate to severe cholestatic pruritis with primary biliar...

                            Brand Name : AV104

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 11, 2023

                            Lead Product(s) : Nalmefene Hydrochloride

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Avior Bio

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            02

                            Hillstream BioPharma

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                            Lead Product(s) : Antibody Drug Conjugate

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Recipient : Applied Biomedical Science Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Licenses Technology to Develop Proprietary HER2 and HER3 Antibody Drug Conjugates against...

                            Details : The agreement aims to develop proprietary multi-format biologics, including bi-specific antibodies, and antibody drug conjugates (ADCs) by leveraging ABSI's technology for human antibodies targeting novel HER2 and HER3 Conformational Epitopes.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            July 06, 2023

                            Lead Product(s) : Antibody Drug Conjugate

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Recipient : Applied Biomedical Science Institute

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            03

                            Hillstream BioPharma

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                            Lead Product(s) : Salinomycin

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : ThinkEquity

                            Deal Size : $2.6 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Announces Closing of Public Offering of Common Stock

                            Details : The Company intends to use the net proceeds for the advancement of its lead drug candidate HSB-1216, which targets ferroptosis, an emerging new anti-cancer mechanism, and the development of other product candidates in the Company’s pipeline.

                            Brand Name : HSB-1216

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 02, 2023

                            Lead Product(s) : Salinomycin

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : ThinkEquity

                            Deal Size : $2.6 million

                            Deal Type : Public Offering

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                            04

                            Hillstream BioPharma

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                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : ThinkEquity

                            Deal Size : $2.6 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Announces Pricing of Public Offering

                            Details : The Company intends to use the net proceeds from the offering for the advancement of HSB-1216, a novel and potent inducer of a powerful mechanism involving iron-mediated cell death, and the development of other product candidates in the Company’s pipel...

                            Brand Name : HSB-1216

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            April 27, 2023

                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : ThinkEquity

                            Deal Size : $2.6 million

                            Deal Type : Public Offering

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                            05

                            Hillstream BioPharma

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                            Hillstream BioPharma

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                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : OncoBay Clinical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Selects OncoBay Clinical to Advance Clinical and Regulatory Development for its Lead Drug...

                            Details : Under the agreement, OncoBay will provide comprehensive clinical and regulatory support for the clinical development program for Hillstream's lead drug HSB-1216, which targets ferroptosis, an emerging new anti-cancer mechanism, resulting in IMCD of drug ...

                            Brand Name : HSB-1216

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            April 13, 2023

                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : OncoBay Clinical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            Hillstream BioPharma

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                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Announces Pharmacokinetic Data of HSB-1216 Supportive of its Development Strategy and Pre...

                            Details : HSB-1216, is a novel and potent inducer of a powerful mechanism involving iron-mediated cell death. It is an emerging new anti-cancer mechanism, resulting in iron mediated cell death (IMCD) of drug resistant cancers.

                            Brand Name : HSB-1216

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 10, 2023

                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Hillstream BioPharma

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Applied Biomedical Science Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Signs Exclusive Option Agreement with Applied Biomedical Science Institute (ABSI) to Lice...

                            Details : Hillstream has the option to license technology for HER2 and HER3 Conformational Domain Bridging Epitopes in antibodies to develop proprietary multi-format biologics against drug resistant cancers including HER2-positive metastatic breast, gastric, lung ...

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            February 13, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Applied Biomedical Science Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            08

                            Hillstream BioPharma

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                            Lead Product(s) : HSB-510

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Announces Acceptance of Abstract at AACR 2023 Annual Meeting Highlighting HSB-510 as Nove...

                            Details : HSB-510 is a novel highly targeted bifunctional inhibitor encapsulated in quatramer with single digit nanomolar IC 50 against PI3-Kδ and HDAC6, which is also known to downregulate MYC, a highly pursued and yet undruggable cancer target.

                            Brand Name : HSB-510

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 08, 2023

                            Lead Product(s) : HSB-510

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Hillstream BioPharma

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                            Hillstream BioPharma

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                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Dana-Farber Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Signs an Exclusive Option Agreement to Advance Next-Generation Anti-MUC1-C Agents for Dru...

                            Details : Dana-Farber has granted under an exclusive option agreement to Hillstream Biopharma Inc., to develop anti-MUC1-C antibodies to selectively deliver Hillstream’s Quatramer-based lead candidate HSB-1216 targeting CSC by the induction of ferroptosis.

                            Brand Name : HSB-1216

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            January 31, 2023

                            Lead Product(s) : HSB-1216

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Dana-Farber Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            Hillstream BioPharma

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                            Lead Product(s) : HSB-1940

                            Therapeutic Area : Oncology

                            Study Phase : Undisclosed

                            Sponsor : Minotaur Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Hillstream BioPharma Announces Development of Proprietary Targeted Biologics, Knob Quatrabodies(TM) (HSB-1940)...

                            Details : By combining Quatramers with their long half-life coated with a PD-1 Picobody™ to create HSB-1940, Hillstream believes it could more efficiently target novel epitopes with greater binding affinity than approved biologics.

                            Brand Name : HSB-1940

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            December 01, 2022

                            Lead Product(s) : HSB-1940

                            Therapeutic Area : Oncology

                            Highest Development Status : Undisclosed

                            Sponsor : Minotaur Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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