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[{"orgOrder":0,"company":"Huadong Medicine","sponsor":"Ashvattha Therapeutics","pharmaFlowCategory":"D","amount":"$45.0 million","upfrontCash":"Undisclosed","newsHeadline":"Ashvattha Therapeutics Announces $69 Million in Series B Financing and up to $45M Exclusive License Agreement with Huadong to Advance Hydroxyl Dendrimer-Based Precision Medicines","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"CHINA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2022","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Huadong Medicine","sponsor":"CARsgen Therapeutics","pharmaFlowCategory":"D","amount":"$181.3 million","upfrontCash":"$29.6 million","newsHeadline":"CARsgen, Huadong Medicine Ink Deal To Sell CAR T-cell Product In China","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"CHINA","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"January 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"},{"orgOrder":0,"company":"Huadong Medicine","sponsor":"Arcutis Biotherapeutics","pharmaFlowCategory":"D","amount":"$94.2 million","upfrontCash":"$30.0 million","newsHeadline":"Arcutis and Huadong Announce Strategic Collaboration and Licensing Agreement for Topical Roflumilast in Greater China and Southeast Asia","therapeuticArea":"Dermatology","highestDevelopmentStatus":"Approved","country":"CHINA","productType":"Small molecule","productStatus":"Approved","date":"August 2023","url1":"","url2":"","graph1":"Dermatology","graph2":"Approved"},{"orgOrder":0,"company":"Huadong Medicine","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"HUADONG MEDICINE Reports Positive Phase I Results for GLP-1 Agonist HDM1002","therapeuticArea":"Endocrinology","highestDevelopmentStatus":"Phase II","country":"CHINA","productType":"Small molecule","productStatus":"New Molecular Entity","date":"June 2024","url1":"","url2":"","graph1":"Endocrinology","graph2":"Phase II"}]

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            HDM1002 is an innovative potent small molecule drug, highly selective full agonist of the GLP-1 receptor. It is being developed for Type 2 Diabetes Mellitus.

            Lead Product(s): HDM1002

            Therapeutic Area: Endocrinology Product Name: HDM1002

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 26, 2024

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            Under the collaboration, Huadong will receive license for both the cream and foam formulations of topical Zoryve (roflumilast), a next generation PDE4 inhibitor, for multiple dermatological conditions including plaque psoriasis, seborrheic dermatitis, and atopic dermatitis.

            Lead Product(s): Roflumilast

            Therapeutic Area: Dermatology Product Name: Zoryve

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Arcutis Biotherapeutics

            Deal Size: $94.2 million Upfront Cash: $30.0 million

            Deal Type: Collaboration August 10, 2023

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            Under the terms of the exclusive licensing agreement, Huadong will advance research and development costs for Ashvattha’s hydroxyl dendrimer clinical candidates, OP-101, D-4517.2 and OP-801, and for additional preclinical candidates.

            Lead Product(s): Dendrimer N-acetyl-cysteine

            Therapeutic Area: Infections and Infectious Diseases Product Name: OP-101

            Highest Development Status: Phase II Product Type: Large molecule

            Recipient: Ashvattha Therapeutics

            Deal Size: $45.0 million Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement April 27, 2022

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            CT053 (zevorcabtagene autoleucel), is a fully human, autologous BCMA CAR T-cell product candidate for the treatment of relapsed/refractory multiple myeloma (R/R MM).

            Lead Product(s): Zevorcabtagene Autoleucel

            Therapeutic Area: Oncology Product Name: CT053

            Highest Development Status: Phase I/ Phase II Product Type: Cell and Gene therapy

            Recipient: CARsgen Therapeutics

            Deal Size: $181.3 million Upfront Cash: $29.6 million

            Deal Type: Collaboration January 16, 2022

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