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                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Humaneered (lenzilumab) is a first-in class antibody that binds to and neutralizes granulocyte-macrophage colony-stimulating factor (GM-CSF), as a treatment for cytokine storm associated with CD19- targeted CAR-T cell therapies.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 12, 2022

                          Lead Product(s) : Lenzilumab,Remdesivir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : A sub-analysis of the Phase 3 LIVE-AIR study of Humaneered (lenzilumab) showed a strong correlation between C-reactive protein (CRP) and outcomes with lenzilumab treatment with the greatest clinical benefit experienced by patients with baseline CRP<150 m...

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 06, 2022

                          Lead Product(s) : Lenzilumab

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Under the agreement, PCI will purchase Humaneered (lenzilumab), for resale and distribution in the event a Conditional Marketing Authorization is received in the UK for use in patients hospitalized with COVID-19.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 16, 2022

                          Lead Product(s) : Lenzilumab,Remdesivir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : PCI Pharma Services

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          04

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : CRISPR/Cas9-Mediated GM-CSF knock-out (GM-CSFko) CAR-T cells, lenzilumab, a proprietary Humaneered first-in-class monoclonal antibody demonstrated reduced apoptosis and enhanced in vivo anti-tumor activity in preclinical models.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 20, 2022

                          Lead Product(s) : Lenzilumab,GM-CSF

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Lenzilumab, a proprietary Humaneered first-in-class mAB that has been proven to neutralize GM-CSF, a cytokine of critical importance in hyperinflammatory cascade, sometimes referred to as cytokine release syndrome, associated with COVID-19 and other indi...

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 19, 2022

                          Lead Product(s) : Lenzilumab

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Humaneered (lenzilumab), is an investigational product that is not currently authorized or approved in any country, now available for certain hospitalized COVID-19 patients through its newly-launched LenzMAP.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 09, 2022

                          Lead Product(s) : Lenzilumab

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Sponsor : Clinigen Group

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : FDA Type C meeting and advice creates alignment on registration pathway for Phase 3 SHIELD trial of Humaneered (lenzilumab), which is designed to inform a potential label that reflects both the clinical benefit of lenzilumab and the economic benefit.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 10, 2022

                          Lead Product(s) : Lenzilumab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Humaneered (Lenzilumab), Phase 3 trial demonstrate treatment of hospitalized COVID-19 patients results in a statistically significant 54% relative improvement in survival without the need for invasive mechanical ventilation.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          December 01, 2021

                          Lead Product(s) : Lenzilumab,Remdesivir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Humanigen is developing lenzilumab as a treatment for cytokine storm associated with CD19-targeted CAR-T cell therapies and exploring the effectiveness of lenzilumab in other inflammatory conditions such as acute Graft versus Host Disease.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 26, 2021

                          Lead Product(s) : Lenzilumab,Azacitidine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          euroPLX 86 Munich
                          Not Confirmed
                          euroPLX 86 Munich
                          Not Confirmed

                          Details : Within ACTIV-5, lenzilumab is the first and only anti-human GM-CSF treatment to be tested in ACTIV-5 as a concomitant therapy with remdesivir compared with remdesivir alone.

                          Brand Name : Humaneered

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 30, 2021

                          Lead Product(s) : Lenzilumab,Remdesivir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Recipient : National Institutes of Health

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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