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    [{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Inaxaplin","moa":"APOL-1","graph1":"Nephrology","graph2":"Phase III","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Inaxaplin","moa":"APOL-1","graph1":"Nephrology","graph2":"Phase II","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Inaxaplin","moa":"APOL-1","graph1":"Nephrology","graph2":"Phase II","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Inaxaplin","moa":"APOL-1","graph1":"Nephrology","graph2":"Phase II","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Inaxaplin","moa":"APOL-1","graph1":"Nephrology","graph2":"Phase II","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"}]

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                            01

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
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                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
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                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Advances Inaxaplin into Phase 3 for APOL1-Mediated Kidney Disease Treatment

                            Details : VX-147 (inaxaplin) is an oral, small-molecule inhibitor of APOL1 channel function, which is being evaluated for the treatment of APOL1-mediated kidney disease.

                            Product Name : VX-147

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 04, 2024

                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
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                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Announces Publication in New England Journal of Medicine of Results from Phase 2 Study of Inaxaplin (VX...

                            Details : (VX-147) inaxaplin is an orally active APOL1 inhibitor aimed at treating the underlying cause of focal segmental glomerulosclerosis (FSGS) and APOL1-mediated kidney disease (AMKD).

                            Product Name : VX-147

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 16, 2023

                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Announces Inaxaplin (VX-147) Granted Breakthrough Therapy Designation by U.S. FDA and Priority Medicine...

                            Details : The primary efficacy endpoint for the final analysis is eGFR slope in patients receiving the VX-147 (inaxaplin) selected dose compared to placebo. The secondary efficacy endpoint is time to composite clinical outcome.

                            Product Name : VX-147

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 06, 2022

                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

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                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Advances VX-147 Into Pivotal Clinical Development for People With APOL1-Mediated Kidney Disease

                            Details : Pathway for accelerated approval using an interim analysis at Week 48 of eGFR slope in VX-147, is first investigational therapy versus placebo, supported by a percent change from baseline in proteinuria.

                            Product Name : VX-147

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 22, 2022

                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Vertex Pharmaceuticals

                            U.S.A arrow
                            AACR Annual meeting
                            Not Confirmed

                            Vertex Pharmaceuticals

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                            AACR Annual meeting
                            Not Confirmed
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                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Announces Positive Results From Phase 2 Study of VX-147 in APOL1-Mediated Focal Segmental Glomeruloscle...

                            Details : VX-147 is the first investigational treatment targeting the underlying cause of APOL1-mediated kidney disease. Treatment with VX-147 led to a statistically significant, substantial and clinically meaningful mean reduction in proteinuria of 47.6%.

                            Product Name : VX-147

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 12, 2021

                            Lead Product(s) : Inaxaplin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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