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Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Cyclo Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"ZyVersa Therapeutics, Inc","sponsor":"Larkspur Health Acquisition","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Agreement","leadProduct":"Hydroxypropyl-Beta Cyclodextrin","moa":"Cholesterol and lipid accumulation","graph1":"Nephrology","graph2":"Phase II","graph3":"ZyVersa Therapeutics, Inc","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"ZyVersa Therapeutics, Inc \/ Larkspur Health Acquisition","highestDevelopmentStatusID":"8","companyTruncated":"ZyVersa Therapeutics, Inc \/ Larkspur Health Acquisition"},{"orgOrder":0,"company":"Cyclo Therapeutics","sponsor":"H.C. 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I","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ZyVersa Therapeutics, Inc \/ George Clinical","highestDevelopmentStatusID":"6","companyTruncated":"ZyVersa Therapeutics, Inc \/ George Clinical"}]

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                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The combined company will focus on the development of Trappsol Cyclo (hydroxypropyl-beta cyclodextrin) for the treatment of Niemann-Pick Disease Type C1.

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 22, 2024

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Cyclo Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Trappsol Cyclo (hydroxypropyl betacyclodextrin) is being evaluated for the treatment of systemic and neurological symptoms of Niemann-Pick Disease Type C1.

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 30, 2024

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin) is being developed to mediate removal of excess cholesterol that damages the kidneys’ filtration system in patients with Diabetic Kidney Disease.

                          Product Name : VAR 200

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 18, 2024

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The combined company will focus on advancing Cyclo Therapeutics’ pivotal Phase 3 global study evaluating Trappsol Cyclo (hydroxypropyl beta cyclodextrin), an orphan drug designated product in the United States and Europe, for Niemann-Pick Disease Type ...

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 27, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Cyclo Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Trappsol Cyclo is a proprietary formulation of hydroxypropyl beta cyclodextrin being developed in phase 3 clinical trials for the potential treatment of Niemann-Pick Disease Type C1, a rare and fatal genetic disease.

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 18, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin, 2HPβCD) is a phase 2a-ready drug in development which has potential to treat multiple kidney diseases, including diabetic kidney disease, rare kidney diseases, FSGS (focal segmental glomerulosclerosis) and Alp...

                          Product Name : VAR 200

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 14, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase I

                          Sponsor : George Clinical

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Trappsol® Cyclo™ (hydroxypropyl beta cyclodextrin), effectively manages the transportation of cholesterol accumulated out of the cells by taking the place of the defective NPC1 protein. It is currently being evaluated for Early Alzheimer’s Disease a...

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 01, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The combined company will focus on advancing Cyclo Therapeutics’ pivotal Phase 3 global study evaluating Trappsol Cyclo (hydroxypropyl beta cyclodextrin), an orphan drug designated product in the United States and Europe, for Niemann-Pick Disease Type ...

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          September 21, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Cyclo Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          09

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Trappsol® Cyclo™ (hydroxypropyl beta cyclodextrin), effectively manages the transportation of cholesterol accumulated out of the cells by taking the place of the defective NPC1 protein. It is currently being evaluated for Early Alzheimer’s Disease.

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 01, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : Cyclo Therapeutics intends to use the proceeds for the support of its Trappsol Cyclo (hydroxypropyl beta cyclodextrin), an orphan drug designated product in the United States and Europe, under clinical trial for Niemann-Pick Disease Type C, a rare and fa...

                          Product Name : Trappsol Cyclo

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 06, 2023

                          Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Rafael Holdings

                          Deal Size : $5.0 million

                          Deal Type : Private Placement

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