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Pharmaceuticals \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals by Idorsia Pharmaceuticals

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Tryvio (aprocitentan) is a first and only endothelin receptor antagonist, which is indicated for the treatment of hypertension in adult patients, in combination with other antihypertensive drugs.

                          Brand Name : Tryvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 15, 2024

                          Lead Product(s) : Aprocitentan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Owkin in-licensed OKN4395, a highly selective, potent, clinic-ready best-in-class dual inhibitor of prostanoid receptors EP2 and EP4, from Idorsia that will enter Phase 1 trials in early 2025.

                          Brand Name : OKN4395

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          May 23, 2024

                          Lead Product(s) : OKN4395

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Owkin

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Jeraygo (aprocitentan), the first endothelin receptor antagonist, treats hypertension in adults by combining it with other antihypertensives to reduce blood pressure.

                          Brand Name : Jeraygo

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 26, 2024

                          Lead Product(s) : Aprocitentan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Tryvio (aprocitentan), an endothelin receptor antagonist, is indicated for treating hypertension when combined with other antihypertensives to lower blood pressure in adults.

                          Brand Name : Tryvio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 20, 2024

                          Lead Product(s) : Aprocitentan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The collaboration focuses on the clinical development & commercialization of ACT-246475 (selatogrel), a reversible, highly selective P2Y12 inhibitor for treating Acute Myocardial Infarction.

                          Brand Name : ACT-246475

                          Molecule Type : Small molecule

                          Upfront Cash : $350.0 million

                          March 18, 2024

                          Lead Product(s) : Selatogrel

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Viatris

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : The collaboration focuses on the clinical development and commercialization of ACT-246475 (selatogrel), a fast-acting, selective P2Y12 inhibitor for treating Acute Myocardial Infarction.

                          Brand Name : ACT-246475

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 27, 2024

                          Lead Product(s) : Selatogrel

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Viatris

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Sosei Heptares gained Japan and Asia-Pacific (ex-China) rights to ACT-541468 (daridorexant), a dual orexin receptor antagonist being developed for the treatment of adult patients with insomnia, from Idorsia.

                          Brand Name : Quviviq

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 31, 2023

                          Lead Product(s) : Daridorexant HCl

                          Therapeutic Area : Sleep

                          Highest Development Status : Approved

                          Recipient : Sosei Heptares

                          Deal Size : $440.0 million

                          Deal Type : Acquisition

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                          08

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Idorsia will reacquire the development and commercialization rights for aprocitentan, a potential novel, effective, once-daily, orally active, dual endothelin A and B receptor antagonist and well-tolerated treatment for resistant hypertension, from Janss...

                          Brand Name : ACT-132577

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 05, 2023

                          Lead Product(s) : Aprocitentan

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Recipient : Johnson & Johnson Innovative Medicine

                          Deal Size : $343.0 million

                          Deal Type : Licensing Agreement

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                          09

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Through the acquisition, Sosei also gains assignment of Pivlaz (clazosentan), for the treatment of cerebral vasospasm, and license rights to daridorexant in the Asia Pacific (ex-China) region.

                          Brand Name : Pivlaz

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 20, 2023

                          Lead Product(s) : Clazosentan Sodium

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Sosei Heptares

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          10

                          Pharma, Lab & Chemical Expo
                          Not Confirmed
                          Pharma, Lab & Chemical Expo
                          Not Confirmed

                          Details : Quviviq (daridorexant) is a dual orexin receptor antagonist (DORA) acting on both orexin 1 and orexin 2 receptors equipotently, approved for the management of adult patients with insomnia.

                          Brand Name : Quviviq

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 10, 2023

                          Lead Product(s) : Daridorexant

                          Therapeutic Area : Sleep

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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