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    [{"orgOrder":0,"company":"IGM Biosciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"IGM Biosciences Initiates First-in-Human Clinical Trial of IGM-8444 for the Treatment of Solid Cancers and Non-Hodgkin\u2019s Lymphoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"September 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"},{"orgOrder":0,"company":"IGM Biosciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"IGM Biosciences to Present First Clinical Data from IGM-2323 in Non-Hodgkin\u2019s Lymphoma at 2020 ASH Annual Meeting","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Large 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              IGM Biosciences

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              IGM Biosciences Announces Refocusing of Sanofi Collaboration

              Details:

              Under the collaboration, Sanofi will create and develop IgM agonist antibodies will now focus exclusively on immunology/inflammation targets by leveraging proprietary IgM antibody technology platform.

              Lead Product(s): Antibody

              Therapeutic Area: Immunology Product Name: Undisclosed

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: Sanofi

              Deal Size: $6,165.0 million Upfront Cash: $150.0 million

              Deal Type: Collaboration April 17, 2024

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              IGM Announces Pricing of $107.3 Million Upsized Public Offering and Concurrent Private Placement

              Details:

              The company intends to use the net proceeds for its pipeline development including, IGM-8444, an IgM antibody targeting Death Receptor 5 (DR5) that is being developed for the treatment of patients with solid and hematologic malignancies.

              Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

              Therapeutic Area: Oncology Product Name: IGM-8444

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: BofA Securities

              Deal Size: $80.0 million Upfront Cash: Undisclosed

              Deal Type: Public Offering June 22, 2023

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              IGM Biosciences Announces Update on IGM-8444 Phase 1 Trial and Future Clinical Development

              Details:

              IGM-8444 is an IgM antibody targeting death receptor 5 (DR5) that is being developed for the treatment of patients with solid tumor including metastatic colorectal cancerand hematologic malignancies.

              Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

              Therapeutic Area: Oncology Product Name: IGM-8444

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 02, 2023

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              IGM Biosciences Announces FDA Clearance to Begin Clinical Studies of Imvotamab in Lupus and Rheumatoid Arthritis

              Details:

              IGM-2323 (imvotamab), a novel IgM-based CD20 x CD3 bispecific antibody T cell engager (TCE), cleared two IND applications, enabling the initiation of Phase 1b studies in both severe systemic lupus erythematosus (SLE) and severe rheumatoid arthritis (RA).

              Lead Product(s): Imvotamab

              Therapeutic Area: Immunology Product Name: IGM-2323

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 31, 2023

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              IGM Biosciences Initiates First-in-Human Clinical Trial of IGM-7354 in Solid Tumors

              Details:

              IGM-7354 is a targeted IL-15/IL-15R IgM immune stimulating antibody for the treatment of patients with solid tumors and hematologic malignancies. IGM-7354 may enhance the immune system’s activity in the tumor microenvironment.

              Lead Product(s): IGM-7354

              Therapeutic Area: Oncology Product Name: IGM-7354

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 17, 2023

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              IGM Biosciences

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              IGM Biosciences Announces Update on IGM-8444 Phase 1 Trial and Future Clinical Development

              Details:

              IGM-8444 is an IgM antibody targeting Death Receptor 5 (DR5) that is being developed for the treatment of patients with solid and hematologic malignancies.

              Lead Product(s): IGM-8444,Bevacizumab,Fluorouracil

              Therapeutic Area: Oncology Product Name: IGM-8444

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 09, 2023

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              IGM Biosciences Presents Data from T cell Engager Portfolio for Hematologic Malignancies at 2022 American Society of Hematology Annual Meeting

              Details:

              Imvotamab (IGM-2323), the first-in-class CD20xCD3 bispecific IgM antibody with dual mechanisms of action, in patients with advanced B cell malignancies.

              Lead Product(s): Imvotamab

              Therapeutic Area: Oncology Product Name: IGM-2323

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 11, 2022

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              IGM Biosciences Announces Closing of Global Collaboration Agreement with Sanofi

              Details:

              The collaboration is for the creation, development, manufacture, and commercialization of IgM antibody agonists against three oncology targets and three immunology/inflammation targets.

              Lead Product(s): Engineered IgM Antibody

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Discovery Product Type: Large molecule

              Partner/Sponsor/Collaborator: Sanofi

              Deal Size: $6,150.0 million Upfront Cash: $150.0 million

              Deal Type: Collaboration May 06, 2022

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              Sanofi and IGM Biosciences Announce Collaboration Agreement for Oncology, Immunology and Inflammation Targets

              Details:

              Under collaboration Sanofi and IGM will lead research, develop and commercialize IgM antibody agonists against three oncology targets and three immunology/inflammation targets by leveraging proprietary IgM antibody technology platform.

              Lead Product(s): Engineered IgM Antibody

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Discovery Product Type: Large molecule

              Partner/Sponsor/Collaborator: Sanofi

              Deal Size: $6,165.0 million Upfront Cash: $150.0 million

              Deal Type: Collaboration March 29, 2022

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              IGM Biosciences Presents Clinical Data from IGM-2323 in Patients with Advanced B Cell Malignancies at 2021 American Society of Hematology Annual Meeting

              Details:

              Based on the results, two Phase 2 studies are being initiated to assess the safety and efficacy of two doses of IGM-2323, in patients with DLBCL and FL. Data demonstrate that IGM-2323 is highly active against multiple subtypes of relapsed/ refractory non-Hodgkin’s lymphoma.

              Lead Product(s): IGM-2323

              Therapeutic Area: Oncology Product Name: IGM-2323

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 11, 2021

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              Farmhispania Group, a leading European CDMO in HPAPI Technologies & High Potency Fermentation.
              One Pharma aims to be one of the leading generic companies in Europe.
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