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Find Clinical Drug Pipeline Developments & Deals by Immatics
The proceeds will be used to fund the continued research and development of company's pipeline, including IMA-203, an adoptive T-cell therapy targeting PRAME (preferentially expressed antigen in melanoma).
IMA203 T cells are directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma, a protein frequently expressed in a large variety of solid cancers, it has potential to address a broad cancer patient population.
IMA203 T cells are directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma, a protein frequently expressed in a large variety of solid cancers, it has potential to address a broad cancer patient population.
The companies will leverage Immatics’ XPRESIDENT® target discovery platform and Moderna’s mRNA technology to develop novel oncology therapies and evaluate Immatics’ investigational IMA203 PRAME TCR-T in combination with Moderna’s investigational PRAME mRNA cancer vaccine.
IMA402 is the first next-generation, half-life extended TCR Bispecific targeting PRAME in HLA-A*02:01-positive patients with PRAME-expressing recurrent and/or refractory solid tumors.
The net proceeds will fund the development of Immatics' differentiated platform technologies that are the foundation of its TCR-based cell therapies including, IMA203 and bispecifics.
IMA203 T cells are directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma, a protein frequently expressed in a large variety of solid cancers, it has potential to address a broad cancer patient population.
The agreement aims for the most advanced TCR-T candidate from the companies’ ongoing collaboration to develop four TCR-based adoptive cell therapies targeting solid tumors using Immatics' XPRESIDENT® technology combined with its XCEPTOR® TCR discovery and engineering platform.
The net proceeds from the offering will be used for working capital and general corporate purposes, including the further development of company's lead product candidate IMA203.
Positively evolving durability profile for IMA203 was observed at higher doses, 6 of 12 patients (50%) treated with more than 1 billion infused TCR-T cells in Phase 1a and Phase 1b cohort A part of trial experienced a confirmed objective response.
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