[{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"ImmPACT Bio","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Merger","leadProduct":"CAR T-cell Therapy","moa":"CD19","graph1":"Oncology","graph2":"Undisclosed","graph3":"ImmPACT Bio","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ ImmPACT Bio","highestDevelopmentStatusID":"1","companyTruncated":"ImmPACT Bio \/ ImmPACT Bio"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"venBio Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Series B Financing","leadProduct":"CD19-CD20 bi-specific CAR-T Cell Therapy","moa":"CD19\/CD20","graph1":"Oncology","graph2":"Phase I","graph3":"ImmPACT Bio","amount2":0.11,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.11,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ venBio Partners","highestDevelopmentStatusID":"6","companyTruncated":"ImmPACT Bio \/ venBio Partners"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2023","type":"Not Applicable","leadProduct":"IMPT-314","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ImmPACT Bio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"ImmPACT Bio \/ Not Applicable"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Not Applicable","leadProduct":"IMPT-314","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ImmPACT Bio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"ImmPACT Bio \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"ImmPACT Bio \/ Not Applicable"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"IMPT-514","moa":"","graph1":"Neurology","graph2":"IND Enabling","graph3":"ImmPACT Bio","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ Not Applicable","highestDevelopmentStatusID":"5","companyTruncated":"ImmPACT Bio \/ Not Applicable"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"Lyell Immunopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Acquisition","leadProduct":"IMPT-314","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ImmPACT Bio","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.029999999999999999,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ Lyell Immunopharma","highestDevelopmentStatusID":"7","companyTruncated":"ImmPACT Bio \/ Lyell Immunopharma"},{"orgOrder":0,"company":"ImmPACT Bio","sponsor":"Lyell Immunopharma","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Acquisition","leadProduct":"IMPT-314","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"ImmPACT Bio","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.029999999999999999,"dosageForm":"","sponsorNew":"ImmPACT Bio \/ Lyell Immunopharma","highestDevelopmentStatusID":"7","companyTruncated":"ImmPACT Bio \/ Lyell Immunopharma"}]

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                          Top Deals by Deal Size (USD bn)

                          01

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                          Details : Lyell will acquire worldwide rights to ImmPACT’s pipeline, the next- gen CD19/CD20 autologous CAR T-cell therapy, which includes IMPT-314, it is currently in clinical development for B-cell lymphoma.

                          Brand Name : IMPT-314

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $30.0 million

                          October 31, 2024

                          Lead Product(s) : IMPT-314

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Lyell Immunopharma

                          Deal Size : $30.0 million

                          Deal Type : Acquisition

                          blank

                          02

                          PharmaVenue
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                          Details : Lyell will acquire worldwide rights to ImmPACT’s pipeline, the next- gen CD19/CD20 autologous CAR T-cell therapy, which includes IMPT-314, it is currently in clinical development for B-cell lymphoma.

                          Brand Name : IMPT-314

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $30.0 million

                          October 24, 2024

                          Lead Product(s) : IMPT-314

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Lyell Immunopharma

                          Deal Size : $30.0 million

                          Deal Type : Acquisition

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                          03

                          PharmaVenue
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                          PharmaVenue
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                          Details : IMPT-514 is a CD19/CD20-targeting chimeric antigen receptor (CAR) T-cell therapy that utilizes a potent bispecific CAR and a 4-1BB, which is under development for Multiple Sclerosis.

                          Brand Name : IMPT-514

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 21, 2024

                          Lead Product(s) : IMPT-514

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : IMPT-314 is a bispecific autologous CAR T-cell therapy targeting the B-cell antigens CD19 and CD20. It was granted FDA fast track designation and will be studied in patients with aggressive B-cell lymphoma, including diffuse large B-cell lymphoma (DLBCL)...

                          Brand Name : IMPT-314

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 15, 2023

                          Lead Product(s) : IMPT-314

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : IMPT-314, a bispecific “OR-Gate” autologous CAR T-cell therapy targeting the B-cell antigens CD19 and CD20. IMPT-314 will be studied in a Phase 1/2 clinical trial in patients with aggressive B-cell lymphoma, including diffuse large B-cell lymphoma (D...

                          Brand Name : IMPT-314

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          January 24, 2023

                          Lead Product(s) : IMPT-314

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Lead Product(s) : CD19-CD20 bi-specific CAR-T Cell Therapy

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : venBio Partners

                          Deal Size : $111.0 million

                          Deal Type : Series B Financing

                          Details : In addition, ImmPACT Bio provided an update to the Phase 1 clinical study evaluating its CD19-CD20 bi-specific CAR T in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma (R/R B-cell NHL) at University of California, Los Angeles (UCLA).

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 20, 2022

                          Lead Product(s) : CD19-CD20 bi-specific CAR-T Cell Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : venBio Partners

                          Deal Size : $111.0 million

                          Deal Type : Series B Financing

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                          07

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
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                          Details : Kalthera is currently progressing a clinical trial at the University of California, Los Angeles (UCLA) Jonsson Comprehensive Cancer Center with a pioneering bispecific chimeric antigen receptor (CAR) T-cell immunotherapy candidate targeting CD19/CD20.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 22, 2021

                          Lead Product(s) : CAR T-cell Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Recipient : Kalthera

                          Deal Size : Undisclosed

                          Deal Type : Merger

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