Lead Product(s) : Dupilumab
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Dupixent Achieves Significant Improvements in Bullous Pemphigoid Study
Details : Dupixent (dupilumab) is a fully human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL4) and interleukin-13 (IL13) pathways.
Brand Name : Dupixent
Molecule Type : Large molecule
Upfront Cash : Not Applicable
September 11, 2024
Lead Product(s) : Dupilumab
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Sovleplenib
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
HUTCHMED Initiates ESLIM-02 Trial Of Sovleplenib for Autoimmune Hemolytic Anemia
Details : HMPL-523 (sovleplenib) is a novel selective small molecule inhibitor targeting spleen tyrosine kinase (Syk), being evaluated for warm antibody autoimmune hemolytic anemia treatment.
Brand Name : HMPL-523
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 21, 2024
Lead Product(s) : Sovleplenib
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ACELYRIN Announces Positive Results from Phase 2b/3 of Izokibep in Psoriatic Arthritis
Details : ABY-035 (izokibep) is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated for the treatment of psoriatic arthritis.
Brand Name : ABY 035
Molecule Type : Large molecule
Upfront Cash : Not Applicable
March 11, 2024
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
ACELYRIN, INC. Provides Update on Izokibep Clinical Development Program
Details : Izokibep is a small protein therapeutic designed to inhibit IL-17A with high potency through tight binding affinity. It is being evaluated in phase 2/3 clinical trials for the treatment of psoriatic arthritis (PsA).
Brand Name : ABY-035
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 27, 2023
Lead Product(s) : Izokibep
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VRDN-001
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Fairmount Funds
Deal Size : $185.0 million
Deal Type : Private Placement
Details : The financing will be used to expand Viridian’s preclinical portfolio of FcRn inhibitors designed to deliver next generation treatments for patients suffering from antibody-mediated autoimmune diseases including VRDN-001, for patients with TED.
Brand Name : VRDN-001
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 30, 2023
Lead Product(s) : VRDN-001
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Fairmount Funds
Deal Size : $185.0 million
Deal Type : Private Placement
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Redmile Group
Deal Size : $155.0 million
Deal Type : Series B Financing
Details : Abcuro will use the proceeds from the financing to complete a Phase 2/3 registrational clinical trial evaluating ABC008, a first-in-class monoclonal antibody targeting killer cell lectin like receptor G1 (KLRG1), for the treatment of inclusion body myosi...
Brand Name : ABC008
Molecule Type : Large molecule
Upfront Cash : Undisclosed
August 17, 2023
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Redmile Group
Deal Size : $155.0 million
Deal Type : Series B Financing
Lead Product(s) : VRDN-001
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : VRDN-001, is a differentiated monoclonal antibody targeting insulin-like growth factor-1 receptor (IGF-1R), a clinically and commercially validated target for the treatment of thyroid eye disease (TED).
Brand Name : VRDN-001
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 10, 2023
Lead Product(s) : VRDN-001
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ABC008 is a first-in-class anti-KLRG1 antibody, designed to treat diseases mediated by highly cytotoxic T cells, including the autoimmune muscle disease inclusion body myositis (IBM), T cell large granular lymphocytic leukemia (T-LGLL), and mature T cell...
Brand Name : ABC008
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 31, 2023
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ABC008 is a first-in-class anti-KLRG1 antibody capable of selectively depleting highly cytotoxic T cells, while sparing regulatory and central memory T cells.
Brand Name : ABC008
Molecule Type : Large molecule
Upfront Cash : Not Applicable
April 03, 2023
Lead Product(s) : ABC008
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Nipocalimab
Therapeutic Area : Immunology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : JNJ-80202135 (nipocalimab) is an investigational, high affinity, fully human, aglycosylated, effectorless, monoclonal antibody that is believed to selectively block the Fc receptor to reduce levels of circulating IgG antibodies, including autoantibodies ...
Brand Name : JNJ-80202135
Molecule Type : Large molecule
Upfront Cash : Not Applicable
February 06, 2023
Lead Product(s) : Nipocalimab
Therapeutic Area : Immunology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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