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Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Acquisition","leadProduct":"Undisclosed","moa":"cGAS","graph1":"Immunology","graph2":"Preclinical","graph3":"Nudge Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Nudge Therapeutics \/ Veralox Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Nudge Therapeutics \/ Veralox Therapeutics"},{"orgOrder":0,"company":"Belhaven Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Hormone","year":"2025","type":"Financing","leadProduct":"Epinephrine","moa":"Adrenergic receptor","graph1":"Immunology","graph2":"Preclinical","graph3":"Belhaven Biopharma","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0.01,"dosageForm":"Nasal Dry Powder","sponsorNew":"Belhaven Biopharma \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Belhaven Biopharma \/ Undisclosed"}]

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                            Belhaven Biopharma

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                            Belhaven Biopharma

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                            Lead Product(s) : Epinephrine

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $11.0 million

                            Deal Type : Financing

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                            Belhaven Raises $11M for Nasdepi(R), Nasal Breakthrough for Anaphylaxis

                            Details : The financing from the proceeds will support the development of Nasdepi (epinephrine). It is being evaluated for the treatment of Anaphylactic reactions due to severe allergies.

                            Product Name : Nasdepi

                            Product Type : Hormone

                            Upfront Cash : Undisclosed

                            January 22, 2025

                            Lead Product(s) : Epinephrine

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $11.0 million

                            Deal Type : Financing

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                            Coya Therapeutics

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                            Lead Product(s) : COYA 301,Glucagon-Like-Peptide-1 Receptor Agonist

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

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                            Coya Therapeutics Expands Pipeline with COYA 303 in Inflammatory Diseases

                            Details : COYA 303 is an investigational biologic combination of COYA 301 and a glucagon-like-peptide-1 receptor agonist designed for subcutaneous administration, for the treatment of inflammatory diseases.

                            Product Name : COYA 303

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 21, 2025

                            Lead Product(s) : COYA 301,Glucagon-Like-Peptide-1 Receptor Agonist

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Hinge Bio

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed

                            Hinge Bio

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : HB2198

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Ridgeback Capital

                            Deal Size : $30.0 million

                            Deal Type : Series A Financing

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                            Hinge Bio Secures $30M Series A’ for GEM-DIMER Platform Therapies

                            Details : The proceeds will support the Company in advancing its lead product candidate, HB2198, into a clinical trial in patients living with Systemic Lupus Erythematosus.

                            Product Name : HB2198

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            January 15, 2025

                            Lead Product(s) : HB2198

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Ridgeback Capital

                            Deal Size : $30.0 million

                            Deal Type : Series A Financing

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                            04

                            Leo Pharma

                            Denmark arrow
                            RNA Therapeutics
                            Not Confirmed

                            Leo Pharma

                            Denmark arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Gilead Sciences

                            Deal Size : $1,700.0 million

                            Deal Type : Partnership

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                            Gilead, LEO Pharma Partner to Develop Programs for Inflammatory Diseases

                            Details : The partnership aims to accelerate the development and commercialization of LEO Pharma’s small molecule oral STAT6 programs for the potential treatment of patients with inflammatory diseases.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : $250.0 million

                            January 11, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Gilead Sciences

                            Deal Size : $1,700.0 million

                            Deal Type : Partnership

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                            05

                            Cyrus Biotechnology

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed

                            Cyrus Biotechnology

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : CYR212

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cyrus Biotechnology Selects CYR212 for Chronic Autoimmune Disease Treatment

                            Details : CYR212 to deplete circulating IgG, it has the potential to be the first approved IgG-lowering agent in myasthenia gravis and immune thrombocytopenia.

                            Product Name : CYR212

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 09, 2025

                            Lead Product(s) : CYR212

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Nudge Therapeutics

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed

                            Nudge Therapeutics

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Veralox Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Veralox Expands Pipeline with Exclusive Option to Acquire Nudge Therapeutics

                            Details : Through the acquisition, Veralox expands its pipeline by including preclinical cyclic AMP-GMP (cGAS) inhibitor compounds.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 09, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Veralox Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            07

                            WuXi Biologics

                            China arrow
                            RNA Therapeutics
                            Not Confirmed

                            WuXi Biologics

                            China arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Candid Therapeutics

                            Deal Size : $925.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Candid Steps up TCE Deal Momentum with $925M WuXi Partnership

                            Details : Under the agreement, Candid will have exclusive global rights to a tri-specific T-cell Engager discovered by the WuXi Biologics platform for treating autoimmune and inflammatory diseases.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            January 06, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Candid Therapeutics

                            Deal Size : $925.0 million

                            Deal Type : Agreement

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                            08

                            Generation Bio

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed

                            Generation Bio

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : siRNA-based Therapy

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Generation Bio Applies ctLNP Technology to Develop siRNA Therapies for Autoimmune

                            Details : siRNA based therapies works by silencing disease-driving targets in T cells, these are being developed for the treatment of autoimmune diseases.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            January 06, 2025

                            Lead Product(s) : siRNA-based Therapy

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Cour Pharmaceuticals

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed

                            Cour Pharmaceuticals

                            U.S.A arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Tolerogenic Nanoparticle

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Genentech

                            Deal Size : $940.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            COUR & Genentech Partner to Develop Autoimmune Tolerogenic Therapy

                            Details : The collaboration aims for the development and commercialization of COUR’s proprietary tolerogenic nanoparticle treatments for an autoimmune disease.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $40.0 million

                            December 03, 2024

                            Lead Product(s) : Tolerogenic Nanoparticle

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Genentech

                            Deal Size : $940.0 million

                            Deal Type : Collaboration

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                            10

                            Polyrizon

                            Israel arrow
                            RNA Therapeutics
                            Not Confirmed

                            Polyrizon

                            Israel arrow
                            RNA Therapeutics
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : PL-14

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Eurofins CDMO

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Polyrizon Enters GMP Manufacturing Agreement for PL-14 Allergy Blocker Trial

                            Details : The collaboration will supply Clinical Trial Material for Polyrizon’s PL-14 allergy blocker, in preparation for a clinical trial.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            December 02, 2024

                            Lead Product(s) : PL-14

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Eurofins CDMO

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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