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Corporation","sponsor":"Syndax Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Axatilimab","moa":"CSF-1R","graph1":"Immunology","graph2":"Approved FDF","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Incyte Corporation \/ Syndax Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Incyte Corporation \/ Syndax Pharmaceuticals"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Genesis Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Technology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Technology","graph2":"Discovery Platform","graph3":"Incyte Corporation","amount2":0.33000000000000002,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Technology","amount2New":0.33000000000000002,"dosageForm":"Undisclosed","sponsorNew":"Incyte Corporation \/ Incyte Corporation","highestDevelopmentStatusID":"3","companyTruncated":"Incyte Corporation \/ Incyte Corporation"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Ponatinib","moa":"ABL1","graph1":"Oncology","graph2":"Phase II","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Incyte Corporation \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Incyte Corporation \/ Inapplicable"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Ruxolitinib Phosphate","moa":"JAK1\/JAK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Topical Cream","sponsorNew":"Incyte Corporation \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Incyte Corporation \/ Inapplicable"},{"orgOrder":0,"company":"Incyte Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Povorcitinib","moa":"JAK1","graph1":"Dermatology","graph2":"Phase III","graph3":"Incyte Corporation","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Incyte Corporation \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Incyte Corporation \/ Inapplicable"}]

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01

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : INCB54707 (povorcitinib) is an oral small-molecule JAK1 inhibitor currently being developed for the treatment of moderate to severe hidradenitis suppurativa (HS).

Product Name : INCB054707

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 17, 2025

Lead Product(s) : Povorcitinib

Therapeutic Area : Dermatology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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02

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Opzelura (ruxolitinib phosphate), a novel topical cream formulation with selective JAK1/JAK2 inhibitor, which is being evaluated for the treatment of prurigo nodularis.

Product Name : Opzelura

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

March 08, 2025

Lead Product(s) : Ruxolitinib Phosphate

Therapeutic Area : Dermatology

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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03

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : The collaboration will focus on researching and developing novel small-molecule medicines by leveraging Genesis’ proprietary AI platform, with an initial emphasis on targets selected by Incyte.

Product Name : Undisclosed

Product Type : Other Small Molecule

Upfront Cash : $30.0 million

February 20, 2025

Lead Product(s) : Undisclosed

Therapeutic Area : Technology

Highest Development Status : Discovery Platform

Recipient : Genesis Therapeutics

Deal Size : $325.0 million

Deal Type : Collaboration

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04

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Niktimvo (axatilimab) is an FDA approved monoclonal antibody that targets CSF-1R. It is approved for new strengths 9, 22 mg vials, for treating chronic graft-versus-host disease.

Product Name : Niktimvo

Product Type : Antibody

Upfront Cash : Inapplicable

January 15, 2025

Lead Product(s) : Axatilimab

Therapeutic Area : Immunology

Highest Development Status : Approved FDF

Sponsor : Syndax Pharmaceuticals

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Zynyz (retifanlimab), is a PD-1 inhibitor antibody drug candidate, which is being evaluated in the late-stage trial studies for treating metastatic NSCLC.

Product Name : Zynyz

Product Type : Large molecule

Upfront Cash : Not Applicable

December 07, 2024

Lead Product(s) : Retifanlimab,Cisplatin,Carboplatin

Therapeutic Area : Oncology

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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06

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : INCB000262 is a potential oral treatment for chronic spontaneous urticaria, which works by inhibiting MRGPRX2.

Product Name : INCB000262

Product Type : Small molecule

Upfront Cash : Not Applicable

November 18, 2024

Lead Product(s) : INCB000262

Therapeutic Area : Immunology

Highest Development Status : Phase II

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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07

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : INCB123667 is a novel, potent and selective oral small molecule inhibitor of CDK2, being investigated in Patients with Advanced Solid Tumors, Notably Ovarian Cancer.

Product Name : INCB123667

Product Type : Small molecule

Upfront Cash : Not Applicable

September 14, 2024

Lead Product(s) : INCB123667

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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08

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Monjuvi (tafasitamab) is a humanized Fc-modified cytolytic CD19-targeting antibody, which is being evaluated in combination with lenalidomide & rituximab for the treatment of R/R follicular lymphoma.

Product Name : Monjuvi

Product Type : Large molecule

Upfront Cash : Not Applicable

August 15, 2024

Lead Product(s) : Tafasitamab,Rituximab,Lenalidomide

Therapeutic Area : Oncology

Highest Development Status : Phase III

Sponsor : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

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09

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Niktimvo (axatilimab) is an investigational monoclonal antibody that targets CSF-1R. It is approved for the treatment of chronic graft-versus-host disease.

Product Name : Niktimvo

Product Type : Large molecule

Upfront Cash : Not Applicable

August 14, 2024

Lead Product(s) : Axatilimab

Therapeutic Area : Immunology

Highest Development Status : Approved

Sponsor : Syndax Pharmaceuticals

Deal Size : Not Applicable

Deal Type : Not Applicable

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10

ELCC
Not Confirmed
ELCC
Not Confirmed

Details : Under the license agreement, MacroGenics will focus on the development of Zynyz (retifanlimab), which is being evaluated in the late-stage trial studies for treating Squamous Cell Anal Carcinoma.

Product Name : Zynyz

Product Type : Large molecule

Upfront Cash : $150.0 million

July 30, 2024

Lead Product(s) : Retifanlimab,Paclitaxel,Carboplatin

Therapeutic Area : Oncology

Highest Development Status : Phase III

Recipient : MacroGenics

Deal Size : $905.0 million

Deal Type : Licensing Agreement

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