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antitrypsin protein","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Inhibrx","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous","sponsorNew":"Inhibrx \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Inhibrx \/ Not Applicable"},{"orgOrder":0,"company":"Inhibrx","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"rhAAT-Fc","moa":"Alpha-1 antitrypsin protein","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Inhibrx","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"Inhibrx \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Inhibrx \/ Not Applicable"},{"orgOrder":0,"company":"Inhibrx","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"INBRX-109","moa":"DR5","graph1":"Oncology","graph2":"Phase II","graph3":"Inhibrx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Inhibrx \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Inhibrx \/ Not Applicable"},{"orgOrder":0,"company":"Inhibrx","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"rhAAT-Fc","moa":"Alpha-1 antitrypsin protein","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Inhibrx","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"Inhibrx \/ Not 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Disease","graph2":"Phase II","graph3":"Inhibrx","amount2":2.2000000000000002,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":2.2000000000000002,"dosageForm":"Infusion","sponsorNew":"Inhibrx \/ Sanofi","highestDevelopmentStatusID":"8","companyTruncated":"Inhibrx \/ Sanofi"}]

Find Clinical Drug Pipeline Developments & Deals by Inhibrx

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                          01

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Sanofi will acquire all the assets and liabilities associated with INBRX-101, a recombinant alpha-1 antitrypsin augmentation therapy currently in a trial for alpha-1 antitrypsin deficiency.

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : $2,196.0 million

                          May 30, 2024

                          Lead Product(s) : SAR447537

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $2,196.0 million

                          Deal Type : Acquisition

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                          02

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Sanofi will acquire assets and liabilities of INBRX-101, a recombinant alpha-1 antitrypsin augmentation therapy in a registrational trial for alpha-1 antitrypsin deficiency.

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : $2,196.0 million

                          January 22, 2024

                          Lead Product(s) : INBRX-101

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $2,196.0 million

                          Deal Type : Acquisition

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                          03

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Under the agreement, non-101 assets, like INBRX-105, INBRX-106, and INBRX-109, will be spun out into a new publicly traded company, Inhibrx Biosciences, separate from the original Company.

                          Product Name : INBRX-105

                          Product Type : Large molecule

                          Upfront Cash : $200.0 million

                          January 22, 2024

                          Lead Product(s) : INBRX-105,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Sanofi

                          Deal Size : $200.0 million

                          Deal Type : Demerger

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                          04

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-109 is a precision-engineered, tetravalent death receptor 5 (DR5) agonist antibody designed to exploit the tumor-biased cell death induced by DR5 activation, which is investigated for Ewing sarcoma.

                          Product Name : INBRX-109

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 02, 2023

                          Lead Product(s) : INBRX-109,Temozolomide,Irinotecan Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-101 is a precisely engineered recombinant human AAT-Fc fusion protein designed to safely achieve and maintain levels of Alpha-1 Antitrypsin Deficiency and received Fast Track Designation.

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 30, 2023

                          Lead Product(s) : INBRX-101

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-101 is a precisely engineered recombinant human AAT-Fc fusion protein designed to safely achieve and maintain levels of alpha-1 antitrypsin (AAT) in patients with emphysema due to alpha-1 antitrypsin deficiency (AATD).

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 26, 2023

                          Lead Product(s) : rhAAT-Fc

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : Under this agreement with Inhibrx, NorthStar will support the development of a prespecified number of Inhibrx’s novel biologic products by providing the Ac-225 supply for the Actinium-225 Conjugated Therapy and access to its integrated radiopharmaceuti...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          January 04, 2023

                          Lead Product(s) : Actinium-225 Conjugated Therapy

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Recipient : NorthStar Medical Radioisotopes

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-109 is a precision-engineered, tetravalent DR5 agonist antibody designed to exploit the tumor-biased cell death induced by DR5 activation being developed for the treatment of patients with unresectable or metastatic conventional chondrosarcoma and ...

                          Product Name : INBRX-109

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 16, 2022

                          Lead Product(s) : INBRX-109

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-101 is precisely engineered recombinant human AAT-Fc fusion protein designed to safely achieve and maintain levels of alpha-1 antitrypsin found in healthy individuals with dosing interval compared to weekly infusion interval plasma-derived AAT ther...

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 04, 2022

                          Lead Product(s) : rhAAT-Fc

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          The Generic Rx Session
                          Not Confirmed
                          The Generic Rx Session
                          Not Confirmed

                          Details : INBRX-101 (rhAAT-Fc) is precisely engineered fusion protein designed to safely achieve and maintain levels of alpha-1 antitrypsin, or AAT, found healthy individuals with less frequent dosing interval compared weekly infusion interval of available plasma-...

                          Product Name : INBRX-101

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 03, 2022

                          Lead Product(s) : rhAAT-Fc

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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