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                          01

                          Medlab Asia & Asia Health
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                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2002 is the first single-dose treatment being explored for the potential to continuously reduce kallikrein activity and prevent attacks in people living with hereditary angioedema.

                          Brand Name : NTLA-2002

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 24, 2024

                          Lead Product(s) : NTLA-2002

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-3001 is a potential one-time gene editing treatment that may normalize AAT protein levels and halt the progression of lung disease associated with alpha-1 antitrypsin deficiency (AATD)

                          Brand Name : NTLA-3001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 30, 2024

                          Lead Product(s) : NTLA-3001

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2002 is the first single-dose treatment being explored for the potential to continuously reduce kallikrein activity and prevent attacks in people living with hereditary angioedema.

                          Brand Name : NTLA-2002

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 02, 2024

                          Lead Product(s) : NTLA-2002

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Through the termination, Intellia opted out of a partnership with Regeneron to develop a factor IX gene editing therapy, for the treatment of hemophilia A and B.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $100.0 million

                          March 22, 2024

                          Lead Product(s) : CRISPR-based Therapy

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : $420.0 million

                          Deal Type : Termination

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                          05

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2001 is designed to inactivate the TTR gene that encodes for the transthyretin (TTR) protein. It is being evaluated for the treatment of transthyretin amyloidosis with cardiomyopathy.

                          Brand Name : NTLA-2001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 18, 2024

                          Lead Product(s) : NTLA-2001

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : The collaboration combines Intellia’s CRISPR platform and ReCode’s selective Organ Targeting lipid nanoparticle to correct cystic fibrosis-causing gene mutations.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 15, 2024

                          Lead Product(s) : CRISPR-based Therapy

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Discovery Platform

                          Sponsor : ReCode Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2002 is the first single-dose investigational treatment being explored in clinical trials for the potential to continuously reduce kallikrein activity and prevent attacks in people living with hereditary angioedema (HAE).

                          Brand Name : NTLA-2002

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 14, 2023

                          Lead Product(s) : NTLA-2002

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2001 is the first-ever investigational in vivo CRISPR-based gene editing therapy, which is investigated for the treatment of transthyretin (ATTR) amyloidosis with cardiomyopathy.

                          Brand Name : NTLA-2001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 18, 2023

                          Lead Product(s) : NTLA-2001

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : NTLA-2002, an investigational CRISPR therapeutic candidate, is the first single-dose investigational treatment being explored in clinical trials for the potential to continuously reduce kallikrein activity and prevent attacks in people living with heredi...

                          Brand Name : NTLA-2002

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          October 13, 2023

                          Lead Product(s) : NTLA-2002

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : The collaboration will leverage Regeneron’s proprietary antibody-targeted AAV vectors and delivery systems and Intellia’s proprietary Nme2 CRISPR/Cas9 systems to develop additional in vivo CRISPR-based gene editing therapies focused on neurological a...

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 03, 2023

                          Lead Product(s) : CRISPR-based Gene Editing Therapy

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Expanded Collaboration

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