Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Roginolisib,Dostarlimab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iOnctura Announces Expansion of Roginolisib Clinical Trial Program to NSCLC
Details : IOA-244 (roginolisib) is a first-in-class small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of non-small cell lung cancer.
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 09, 2024
Lead Product(s) : Roginolisib,Dostarlimab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase II/ Phase III
Sponsor : Syncona Limited
Deal Size : $85.9 million
Deal Type : Series B Financing
iOnctura Announces €80 Million Series B Financing to Progress Pipeline Through Phase II
Details : The financing will be used to accelerate the development of IOA-244 (roginolisib), which is being evaluated in the mid-stage clinical trial studies for the treatment of uveal melanoma.
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Undisclosed
June 20, 2024
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase II/ Phase III
Sponsor : Syncona Limited
Deal Size : $85.9 million
Deal Type : Series B Financing
Lead Product(s) : Cambritaxestat,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
US FDA Grants Orphan Drug Designation for iOnctura's First-in-class Autotaxin Therapy
Details : IOA-289 (cambritaxestat) is a novel, first-in-class inhibitor of autotaxin with a unique binding mode. It is being evaluated for the treatment of pancreatic cancer.
Brand Name : IOA-289
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 07, 2024
Lead Product(s) : Cambritaxestat,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class small molecule allosteric modulator of PI3Kδ. It is being evaluated for the treatment of metastatic uveal melanoma.
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 31, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : IOA-359
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Clavius Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Licensing Agreement
iOnctura and Clavius Exercise Option for TGF-β Pathway Inhibitor
Details : Under the agreement, iOnctura gets exclusive global development rights to IOA-359, a novel oral, small molecule, TGF–β pathway inhibitor that will be evaluated in solid tumors.
Brand Name : IOA-359
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 03, 2023
Lead Product(s) : IOA-359
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Clavius Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : IOA-359
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Health Holland
Deal Size : Undisclosed
Deal Type : Funding
iOnctura Expands Pipeline And Receives Development Grant From Health Holland And KWF
Details : The grant will accelerate iOnctura's preclinical investigation of IOA-359, a novel oral, small molecule, TGF–β pathway inhibitor that will be evaluated in solid tumors.
Brand Name : IOA-359
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 03, 2023
Lead Product(s) : IOA-359
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Health Holland
Deal Size : Undisclosed
Deal Type : Funding
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class, non-ATP-competitive, allosteric modulator of PI3K delta which prevents tumor proliferation and breaks immune tolerance in patients with solid and hematological tumors.
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 28, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : IOA-244 (roginolisib) is a first-in-class, non-ATP-competitive, allosteric modulator of PI3K which prevents tumor proliferation and breaks immune tolerance in patients with solid and hematological tumors.
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 16, 2023
Lead Product(s) : Roginolisib
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
iOnctura Provides Development Update on First-In-Class Semi-Allosteric PI3Kδ Inhibitor Program
Details : IOA-244 is a first-in-class semi-allosteric, non-ATP competitive, small molecule PI3Kδ inhibitor which has shown high beneficial tolerability and clinical benefit profile. PI3Kδ over-expression stimulates multiple cancer mechanisms and an oncogenic rol...
Brand Name : IOA-244
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 05, 2023
Lead Product(s) : Roginolisib,Avelumab,Pemetrexed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : IOA-289,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : European Investment Council
Deal Size : $18.5 million
Deal Type : Funding
Details : IOA-289 is the first ATX inhibitor in clinical development for cancer. It is an oral small molecule non-competitive inhibitor with novel binding chemistry and a safe clinical profile. Inhibiting ATX with IOA-289 directly prevents the proliferation of can...
Brand Name : IOA-289
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 20, 2022
Lead Product(s) : IOA-289,Gemcitabine,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : European Investment Council
Deal Size : $18.5 million
Deal Type : Funding
LOOKING FOR A SUPPLIER?