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Biotherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"LN-145","moa":"PD-L1","graph1":"Oncology","graph2":"Phase II","graph3":"Iovance Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Iovance Biotherapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Iovance Biotherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Iovance Biotherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Inapplicable","leadProduct":"LN-145","moa":"PD-L1","graph1":"Oncology","graph2":"Phase II","graph3":"Iovance Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Biotherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2021","type":"Inapplicable","leadProduct":"Interleukin 2","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Iovance Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"Iovance Biotherapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Iovance Biotherapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Iovance Biotherapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"Lifileucel","moa":"T-cell receptor","graph1":"Oncology","graph2":"Approved FDF","graph3":"Iovance 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II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Iovance Biotherapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Iovance Biotherapeutics \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-145 is a ready-to-infuse TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for patients with metastatic NSCLC.

                          Product Name : LN-145

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          April 03, 2024

                          Lead Product(s) : LN-145

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : Lovance intends to use proceeds to support the commercial launch of Amtagvi (lifileucel), a tumor-derived autologous T-cell immunotherapy for unresectable or metastatic melanoma.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 20, 2024

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Jefferies

                          Deal Size : $211.0 million

                          Deal Type : Public Offering

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                          03

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : Amtagvi (lifileucel) is an engineered TIL therapy indicated for adults with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          February 16, 2024

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : Iovance intends to use the proceeds to fund preparations for the commercial launch of LN-144 (lifileucel), when approved and to support ongoing clinical programs including its NSCLC registration-directed study and its frontline advanced melanoma Phase 3 ...

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          October 07, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $150.0 million

                          Deal Type : Public Offering

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                          05

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-145 TIL therapy for patients who have progressed on or after chemotherapy and anti-PD-1 therapy for advanced (unresectable or metastatic) NSCLC without EGFR, ROS or ALK genomic mutations

                          Product Name : LN-145

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          October 07, 2023

                          Lead Product(s) : LN-145,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          September 14, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : Iovance intends to use the proceeds to fund preparations for the commercial launch of LN-144 (lifileucel), when approved and to support ongoing clinical programs including its NSCLC registration-directed study and its frontline advanced melanoma Phase 3 ...

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 13, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $172.5 million

                          Deal Type : Public Offering

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                          08

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 15, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          May 26, 2023

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Pharma Live Expo
                          Not Confirmed
                          Pharma Live Expo
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Product Name : Amtagvi

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 24, 2023

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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