[{"orgOrder":0,"company":"Iovance Biotherapeutics","sponsor":"Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Large molecule","year":"2020","type":"Licensing Agreement","leadProduct":"IOV-3001","moa":"IL-2","graph1":"Oncology","graph2":"Preclinical","graph3":"Iovance Biotherapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Iovance Biotherapeutics \/ Iovance Biotherapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Iovance Biotherapeutics \/ Iovance Biotherapeutics"},{"orgOrder":0,"company":"Iovance Biotherapeutics","sponsor":"Cellectis","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"Cell and Gene therapy","year":"2020","type":"Licensing Agreement","leadProduct":"Tumor infiltrating lymphocytes","moa":"","graph1":"Oncology","graph2":"Phase 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II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Iovance Biotherapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Iovance Biotherapeutics \/ Not Applicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-145 is a ready-to-infuse TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for patients with metastatic NSCLC.

                          Brand Name : LN-145

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 04, 2024

                          Lead Product(s) : LN-145

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Lovance intends to use proceeds to support the commercial launch of Amtagvi (lifileucel), a tumor-derived autologous T-cell immunotherapy for unresectable or metastatic melanoma.

                          Brand Name : Amtagvi

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 20, 2024

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Jefferies LLC

                          Deal Size : $211.0 million

                          Deal Type : Public Offering

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                          03

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Amtagvi (lifileucel) is an engineered TIL therapy indicated for adults with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody.

                          Brand Name : Amtagvi

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          February 16, 2024

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 14, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Iovance intends to use the proceeds to fund preparations for the commercial launch of LN-144 (lifileucel), when approved and to support ongoing clinical programs including its NSCLC registration-directed study and its frontline advanced melanoma Phase 3 ...

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 13, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Goldman Sachs & Co.

                          Deal Size : $172.5 million

                          Deal Type : Public Offering

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                          06

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Iovance intends to use the proceeds to fund preparations for the commercial launch of LN-144 (lifileucel), when approved and to support ongoing clinical programs including its NSCLC registration-directed study and its frontline advanced melanoma Phase 3 ...

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          July 10, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Goldman Sachs & Co.

                          Deal Size : $150.0 million

                          Deal Type : Public Offering

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                          07

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-145 TIL therapy for patients who have progressed on or after chemotherapy and anti-PD-1 therapy for advanced (unresectable or metastatic) NSCLC without EGFR, ROS or ALK genomic mutations

                          Brand Name : LN-145

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          July 10, 2023

                          Lead Product(s) : LN-145,Cyclophosphamide,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 15, 2023

                          Lead Product(s) : Lifileucel,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 26, 2023

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : LN-144 (lifileucel) is a tumor infiltrating lymphocyte therapy in combination with pembrolizumab is intended as a treatment for patients with advanced melanoma who progressed on or after prior anti-PD-1/L1 therapy and targeted therapy.

                          Brand Name : LN-144

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 24, 2023

                          Lead Product(s) : Lifileucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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