Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Final Data From The AGENT Study Confirms Topline Results
Details : In AGENT study, patients with non-resectable mCRC treated with arfolitixorin in combination with 5-FU, oxaliplatin and bevacizumab did not achieve a statistically significant overall response rate of ≥ 10% as compared to patients treated with the stand...
Brand Name : Modufolin
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 25, 2022
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Isofol Reports Data from the AGENT Study
Details : Progression-free survival (PFS) was approximately 12.8 months for the arfolitixorin arm and 11.6 months for the control arm, with a P-value of 0.76. Data for this endpoint is not final but it is not deemed to change significantly moving forward.
Brand Name : Modufolin
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 07, 2022
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : As the key active metabolite of the widely used folate-based drugs, arfolitixorin can potentially benefit all patients with advanced colorectal cancer, as it does not require complicated metabolic activation to become effective.
Brand Name : Arfox
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 22, 2022
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Arfox (Arfolitixorin), is the first and only immediately active folate being developed to increase the efficacy of standard of care chemotherapy for advanced colorectal cancer.
Brand Name : Arfox
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 03, 2021
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : As the first and only pure form of the folate ([6R]-MTHF) that increases 5FU-cytotoxicity, arfolitixorin is currently being evaluated in the global pivotal Phase III AGENT study used for treatment of patients with metastatic colorectal cancer (mCRC).
Brand Name : Arfox
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 23, 2021
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The patent application that will be granted includes a dose regimen involving two or more injections of arfolitixorin in combination with 5-fluorouracil (5-FU).
Brand Name : Arfox
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 22, 2021
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The iDSMB has recommended continuation of the global Phase III AGENT study with 440 patients, in accordance with the study design for the drug candidate, arfolitixorin. Isofol expects the top line results for the AGENT study to be available during H1 202...
Brand Name : Arfox
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 19, 2021
Lead Product(s) : Arfolitixorin,Fluorouracil,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Fluorouracil
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The abstract present results from the Phase I/IIa ISO-CC-005 study which shows a correlation between clinical benefit and gene expression of the folate pathway in patients with metastatic colorectal cancer treated with 5-FU-based chemotherapy in combinat...
Brand Name : Modufolin
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 15, 2021
Lead Product(s) : Arfolitixorin,Fluorouracil
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Oxaliplatin,Fluorouracil
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Isofol Reaches 440 Patients in Global Phase III Agent Study
Details : Isofol’s drug candidate, arfolitixorin, is evaluated for treatment of patients with first-line metastatic colorectal cancer (mCRC). The AGENT study is currently being conducted in the U.S., Canada, Europe, Australia and Japan at more than 90 clinics.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 09, 2020
Lead Product(s) : Arfolitixorin,Oxaliplatin,Fluorouracil
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Arfolitixorin,Oxaliplatin,Fluorouracil
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : PALADIN LABS
Deal Size : $100.0 million
Deal Type : Licensing Agreement
Isofol Announces Licensing Agreement for Paladin Labs Inc. To Commercialize Arfolitixorin in Canada
Details : The license agreement is initially focused on the development and commercialization of arfolitixorin as first-line treatment for metastatic colorectal cancer (mCRC) patients in Japan, which is projected to be the second largest addressable patient market...
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : $103.0 million
November 02, 2020
Lead Product(s) : Arfolitixorin,Oxaliplatin,Fluorouracil
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : PALADIN LABS
Deal Size : $100.0 million
Deal Type : Licensing Agreement
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