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Find Clinical Drug Pipeline Developments & Deals for Istaroxime
The collaboration aims to research on PST2744 (istaroxime), a SERCA2a activator, an important target for the Company’s cardiovascular portfolio, including heart failure.
Under the agreement, Lee will be responsible for the development and commercialization of Windtree’s product candidate PST2744 (istaroxime), a first-in-class dual-mechanism therapy, in Greater China, including for acute heart failure and cardiogenic shock.
PST2744 (Istaroxime) is a Na/K ATPase 2 inhibitor & a first-in-class dual mechanism therapy designed to improve both systolic and diastolic cardiac function. It is under phase 2 clinical development for the treatment of cardiogenic shock.
PST2744 (istaroxime) is a novel first-in-class therapy that is designed to improve systolic contraction and diastolic relaxation of the heart while also increasing blood pressure. It is under phase 2 clinical development for the treatment of Early Cardiogenic Shock.
The Company intends to use the net proceeds of the offering to extend enrollment and complete a Phase 2 clinical trial for PST2744 (istaroxime), a potent inhibitor of Na+,K+-ATPase, in cardiogenic shock.
The Company will use the proceeds to extend enrollment and complete a Phase 2 clinical trial for PST2744 (istaroxime), a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase), in cardiogenic shock.
PST2744 (istaroxime) is a positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+- ATPase with a complimentary mechanism of the SERCA2a calcium pump activation on the sarcoplasmic reticulum enhancing calcium reuptake from the cytoplasm.
PST2744 (istaroxime) is a positive inotropic agent that increases myocardial contractility by inhibiting of Na+/K+- ATPase, it also facilitates myocardial relaxation via SERCA2a calcium pump activation on sarcoplasmic reticulum enhancing cytoplasmic calcium reuptake.
PST2744 (istaroxime) is a positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+- ATPase with a complimentary mechanism of the SERCA2a calcium pump activation on the sarcoplasmic reticulum enhancing calcium reuptake from the cytoplasm.
Istaroxime (PST2744) is a first-in-class dual mechanism therapy designed to improve both systolic and diastolic cardiac function. Istaroxime is a positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+- ATPase.